Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Elevated postoperative serum CA19-9 level is associated with reduced survival and early development of distant metastatic disease in pancreatic cancer |
Human | SLC5A8 | 160728 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | SLC5A8 may function as a tumor suppressor gene whose silencing may contribute to carcinogenesis and progression of pancreatic cancer |
Human | GATA5 | 140628 | GATA binding protein 5 | While hypermethylation of GATA-5 seems to be a universal feature among human tumors, infrequent methylation of GATA-4, and its corresponding overexpression, appears unique to pancreatic cancer from other tumor types reported thus far |
Human | MMP21 | 118856 | matrix metallopeptidase 21 | MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer |
Human | OSBPL5 | 114879 | oxysterol binding protein-like 5 | OSBPL5 is relatd to invasion and poor prognosis in pancreatic cancer |
Human | REG4 | 83998 | regenerating islet-derived family, member 4 | Overexpression of REG4 is associated with pancreatic cancer |
Human | PDGFD | 80310 | platelet derived growth factor D | Overexpression of PDGF-D is associated with pancreatic cancer |
Human | HHIP | 64399 | hedgehog interacting protein | The different pattern of expression and abnormal localization in the diseased pancreas suggest that the enhanced activation of hedgehog signaling in in pancreatic cancer and pancreatic duct carcinoma |
Human | CXCL16 | 58191 | chemokine (C-X-C motif) ligand 16 | CXCL16 seems to play an important role in the pathobiology of pancreatic cancer |
Human | NDRG2 | 57447 | NDRG family member 2 | NDRG2 gene might express differently between normal tissues and cancer tissues, and might play an important role in the development of pancreatic cancer and liver cancer |
Human | SMURF1 | 57154 | SMAD specific E3 ubiquitin protein ligase 1 | SMURF1 was identified by amplication in a pancreatic cancer cell line |
Human | MMP26 | 56547 | matrix metallopeptidase 26 | The putative role of MMP-26 as a marker of metastasesin pancreatic cancer warrants further studies |
Human | SLC39A4 | 55630 | solute carrier family 39 (zinc transporter), member 4 | therapeutic strategy whereby ZIP4 is targeted to control pancreatic cancer growth |
Human | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | Both BRAF and FBXW7 mutations functionally activate kinase effectors important in pancreatic cancer and extend the potential options for therapeutic targeting of kinases in the treatment of phenotypically distinct pancreatic adenocarcinoma subsets |
Human | UGT1A7 | 54577 | UDP glucuronosyltransferase 1 family, polypeptide A7 | UGT1A7 polymorphisms do not predispose patients to the development of pancreatic cancer and pancreatitis |
Human | KRT20 | 54474 | keratin 20 | CK 20 expression defines a subtype of pancreas cancer with important biologic properties; when present, CK 20 expression is an early event in pancreatic carcinogenesis identifiable in precursor lesions |
Human | FXYD5 | 53827 | FXYD domain containing ion transport regulator 5 | Dysadherin is able to modulate actin structures, stimulate cell motility, and contribute directly to the metastatic potential of human pancreatic cancer cells |
Human | NT5DC3 | 51559 | 5'-nucleotidase domain containing 3 | TU12B1-TY may contribute to the development and/or progression of human pancreatic cancer |
Human | A4GNT | 51146 | alpha-1,4-N-acetylglucosaminyltransferase | Up-regulation of alpha-1,4-N-acetylglucosaminyltransferase is associated with pancreatic cancer |
Human | GMNN | 51053 | geminin, DNA replication inhibitor | geminin is overexpressed in human pancreatic cancer and downregulated by apigenin which may contribute to the antitumor effect of this natural flavonoid |
Human | NOX4 | 50507 | NADPH oxidase 4 | reactive oxygen species generated by Nox4, at least in part, transmit cell survival signals through the AKT-ASK1 pathway in pancreatic cancer cells and their depletion leads to apoptosis NOX4 has a role in inhibiting apoptosis with reactive oxygen species in pancreatic cancer cells |
Human | CACYBP | 27101 | calcyclin binding protein | CacyBP/SIP protein might play an important role in the process of pancreatic carcinogenesis and high-level CacyBP/SIP expression might be related to the malignant potential of pancreatic cancer |
Human | SLC7A11 | 23657 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | The results suggest that the x(c)(-) transporter by enhancing glutathione biosynthesis plays a major role in pancreatic cancer growth, therapy resistance and represents a potential therapeutic target for the disease |
Human | LDOC1 | 23641 | leucine zipper, down-regulated in cancer 1 | These observations suggest that LDOC1 is a novel regulator of NF-kappaB that can affect the PMA or TNF-alpha-mediated pathway to apoptosis through inhibition of NF-kappaB activation in BxPC3 pancreatic cancer cells |
Human | SULF1 | 23213 | sulfatase 1 | High expression of Hsulf-1 occurs in the stromal elements as well as in the tumor cells in pancreatic cancer and interferes with heparin-binding growth factor signaling |