| Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | silencing of HIN-1 expression and methylation of its promoter occurs in multiple human cancer types, suggesting that elimination of HIN-1 function may contribute to several forms of epithelial tumorigenesis |
| Human | HACE1 | 57531 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | HACE1 is a candidate chromosome 6q21 tumor-suppressor gene involved in multiple cancers |
| Human | ABCA12 | 26154 | ATP-binding cassette, sub-family A (ABC1), member 12 | study identified two novel ABCA12 mutations in two unrelated non-bullous congenital ichthyosiform erythroderma patients; both patients presented with multiple skin malignancies including malignant melanoma |
| Human | NPRL2 | 10641 | nitrogen permease regulator-like 2 (S. cerevisiae) | TUSC4/NPRL2, a novel PDK1-interacting protein, plays a role in regulating the Src/PDK1 signaling pathway and cell sensitivity to multiple cancer chemotherapeutic drugs |
| Human | RASSF2 | 9770 | Ras association (RalGDS/AF-6) domain family member 2 | A novel methylation marker for multiple malignancies; suppresses breast tumor cell growth in vitro and in vivo |
| Human | TP53 | 7157 | tumor protein p53 | These findings indicate that R337H may be a low penetrance mutant which predisposes to multiple cancers Increased risk of developing multiple primary cancers |
| Human | SULT1A1 | 6817 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | The SULT1A1*2 revealed contrasting risk association for upper aerodigestive tract cancers and conferred significant increased risk of breast cancer to Asian but not Causcasian women in patients with multiple tobacco-related cancers |
| Human | AURKA | 6790 | aurora kinase A | STK15 T+91A variant is a low penetrance cancer susceptibility allele affecting multiple cancer types |
| Human | OPCML | 4978 | opioid binding protein/cell adhesion molecule-like | OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies |
| Human | MSH2 | 4436 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | Extensive screening of 59 multiple-case breast cancer families did not identify any coding region mutations or larger genomic alterations in MSH2 that might implicate MSH2 as a breast cancer susceptibility gene |
| Human | MLH1 | 4292 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | Germline epimutation of MLH1 is associated with multiple cancers |
| Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | found that the 49G>A polymorphism in the CTLA-4 leading sequence causing (17)Ala to (17)Thr amino acid substitution is associated with increased susceptibility to multiple cancers, including lung, breast, esophagus, and gastric cardia cancers |
| Human | CDKN2A | 1029 | cyclin-dependent kinase inhibitor 2A | Increased risk of developing multiple primary cancers |
| Human | CASP8 | 841 | caspase 8, apoptosis-related cysteine peptidase | A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers |
| Human | BRCA2 | 675 | breast cancer 2, early onset | Inactivation of a single gene within the BRCA2 pathway can increase risks for multiple cancers and inactivation of a different gene in the same pathway may have similar effects |
| Human | BRCA1 | 672 | breast cancer 1, early onset | Inactivation of a single gene within the BRCA1 pathway can increase risks for multiple cancers and inactivation of a different gene in the same pathway may have similar effects |
| Human | BARD1 | 580 | BRCA1 associated RING domain 1 | BARD1 Cys557Ser is an ancient variant that confers risk of single and multiple primary breast cancers, and this risk extends to carriers of the BRCA2 999del5 mutation |
| Human | ATM | 472 | ataxia telangiectasia mutated | Study reports the screening of 782 multiple-case breast cancer families that identified two additional index cases with ATM 7271T>G and phylogenetic sequence analysis showed that Valine2424 is a highly conserved residue at least two ATM mutations are associated with a sufficiently high risk of breast cancer to be found in multiple-case breast cancer families; genetic susceptibility for breast cancer |
| Human | ZFHX3 | 463 | zinc finger homeobox 3 | Two somatic mutations (shortening of a polypyrimidine tract [Poly(T)n] and a deletion beginning at codon 3381 (3381del)) were each observed in multiple prostate cancer samples and both appear to have an impact on ATBF1 gene function and expression |
