Debug Stats | ### Total Build Time: 42 ms 33.905 KB CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 370 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 556 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytesCONCEPT_RELATIONSHIPS gt=29 ms Completed: 29 ms rowSize= 15.886 KBCONCEPT_GENES gt=10 ms Completed: 10 ms rowSize= 15.875 KBCONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.170 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
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Relationships (36)
Relation Types: diso_to_anat : 17 diso_to_chem : 1 diso_to_diso : 16 diso_to_gene : 2
Relationships: gene_associated_with_disease : 2 gene_product_malfunction_associated_with_disease : 1 is_abnormal_cell_of_disease : 6 is_associated_anatomic_site_of : 2 is_finding_of_disease : 5 is_normal_cell_origin_of_disease : 1 is_normal_tissue_origin_of_disease : 2 is_not_abnormal_cell_of_disease : 5 is_not_finding_of_disease : 1 is_primary_anatomic_site_of_disease : 1 isa : 1 may_be_associated_disease_of_disease : 3 may_be_finding_of_disease : 3 may_be_molecular_abnormality_of_disease : 3 | |
DISO_to_ANAT | | is_abnormal_cell_of_disease |
Adenocarcinoma Cell C1510779 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Cancer Cell C0334227 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Carcinoma Cell C1518174 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Epithelial Cells C0014597 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
Epithelial Tissue C0014609 | DISO_to_ANAT | | is_primary_anatomic_site_of_disease |
Female Reproductive System C0700038 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Malignant Squamous Cell C1518245 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Malignant Stromal Cell C1518246 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Cell C0597032 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Epithelial Cell C1513959 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Neoplastic Epithelial Clear Cell C1513960 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Glandular Cell C1513973 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Neoplastic Smooth Muscle Cell C1514098 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Neoplastic Squamous Cell C1514101 | DISO_to_ANAT | | is_associated_anatomic_site_of |
Ovary C0029939 | DISO_to_ANAT | | is_associated_anatomic_site_of |
Reproductive system C1261210 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
Structure of germinal epithelium of ovary C0227875 | DISO_to_CHEM | | gene_product_malfunction_associated_with_disease |
beta Catenin C0105770 | DISO_to_DISO | | may_be_finding_of_disease |
Abdominal mass C0000734 | DISO_to_DISO | | may_be_finding_of_disease |
Ascites C0003962 | DISO_to_DISO | | may_be_molecular_abnormality_of_disease |
Beta Catenin Gene Mutation C1511111 | DISO_to_DISO | | is_finding_of_disease |
Carcinomatous Component Present C1707292 | DISO_to_DISO | | may_be_associated_disease_of_disease |
Endometrial Carcinoma C0476089 | DISO_to_DISO | | may_be_associated_disease_of_disease |
Endometrial Endometrioid Adenocarcinoma C1336905 | DISO_to_DISO | | may_be_associated_disease_of_disease |
Endometriosis C0014175 |
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Genes (12)
Species: human : 12 | |
Human | SPEN | 23013 | spen homolog, transcriptional regulator (Drosophila) | SHARP gene and protein expression is elevated in human colon and ovarian endometrioid adenocarcinomas carrying gene defects leading to beta-catenin dysregulation | Human | WFDC2 | 10406 | WAP four-disulfide core domain 2 | Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas. | Human | TP63 | 8626 | tumor protein p63 | p63, CK 5/6, and CK 14 were respectively expressed in 92.6%, 75.0%, and 52.9% of the squamous cell carcinomas of the lung, 10.2%, 20.0%, and 7.4% of the ductal carcinomas of the breast, 12.9%, 34.4%, and 11.8% of the serous and 25.0%, 0%, and 0% of the endometrioid carcinomas of the ovary. | Human | REEP5 | 7905 | receptor accessory protein 5 | In this study, we determined the frequency of microsatellite instability in 74 ovarian endometrioid carcinomas using four microsatellite markers (BAT25, BAT26, D5S346, D17S250), and examined hMLH1 and hMSH2 protein expression. | Human | TP53 | 7157 | tumor protein p53 | p53 mutation was observed in 4 of 13 specimens of endometriosis coexisting with ovarian clear cell carcinoma, whereas no mutations were detected in solitary endometriosis or endometriosis coexisting with ovarian endometrioid carcinoma | Human | MUC5AC | 4586 | mucin 5AC, oligomeric mucus/gel-forming | In this study, we compared the expression of MUC2 and MUC5AC apomucins in 10 colonic adenocarcinomas metastatic with the ovary, 10 ovarian endometrioid carcinomas (4 primary, 6 metastatic), and 32 primary mucinous ovarian tumors (12 cystadenomas, 10 borderline tumors, and 10 cystadenocarcinomas). | Human | MSH2 | 4436 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | Loss of hMLH1 and/or hMSH2 expression was found in nine of 15 microsatellite instability-high ovarian endometrioid carcinomas | Human | CD99 | 4267 | CD99 molecule | The expression of MIS, inhibin, and CD99 was evaluated by immunohistochemistry in a series of 19 sex cord-stromal tumors and seven ovarian endometrioid carcinomas resembling sex cord-stromal tumors. Mullerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors. | Human | IGFBP3 | 3486 | insulin-like growth factor binding protein 3 | IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian endometrioid carcinoma | Human | CTNNB1 | 1499 | catenin (cadherin-associated protein), beta 1, 88kDa | The activity of beta-catenin (beta-cat), a key component of the Wnt signaling pathway, is deregulated in about 40% of ovarian endometrioid adenocarcinomas (OEAs), usually as a result of CTNNB1 gene mutations. Prior studies have shown that ovarian endometrioid adenocarcinomas (OEAs) often carry mutations in the CTNNB1 gene, which encodes beta-catenin, a critical component of the Wnt signaling pathway. Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. | Human | BAX | 581 | BCL2-associated X protein | Bax may not play a direct role in the genesis of ovarian endometrioid carcinoma, regardless of microsatellite instability status | Human | AMH | 268 | anti-Mullerian hormone | Mullerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors. |
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