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Genes (16)
Species: human : 16 | |
Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | These data show that GGT is expressed in many common ovarian epithelial neoplasms. | Human | INHBE | 83729 | inhibin, beta E | Expression of gonadotropin and activin receptor messenger ribonucleic acid in human ovarian epithelial neoplasms. This study is designed to examine the expression of inhibin and activin subunits as well as activin receptor in primary ovarian epithelial tumors to explore their role in the process of ovarian epithelial tumorigenesis. But exact roles of inhibin and activin in ovarian epithelial tumors remain to be defined. | Human | C19orf33 | 64073 | chromosome 19 open reading frame 33 | RESULTS: IMUP-1 (4.0-fold) and IMUP-2 (2.4-fold) mRNA expression in ovarian epithelial tumors were significantly higher than in normal ovarian tissues (p < 0.05). results showed the up-regulation of IMUP-1 and IMUP-2 in human ovarian epithelial tumors and suggested that the altered mRNA level of these molecules is possibly associated with ovarian tumorigenesis CONCLUSION: These results showed the up-regulation of IMUP-1 and IMUP-2 in human ovarian epithelial tumors and suggested that the altered mRNA level of these molecules is possibly associated with ovarian tumorigenesis. IMUP-1 and IMUP-2 genes are up-regulated in human ovarian epithelial tumors. However, the staining intensity of IMUP-1 and IMUP-2 in ovarian epithelial tumors were not different between histological types or grades. PATIENTS AND METHODS: This study was performed to determine mRNA expression and intracellular localization of the IMUP-1 and IMUP-2 in ovarian epithelial tumors by RT-PCR and immunohistochemical staining using human IMUP-1 and IMUP-2 monoclonal antibodies. However, the roles of IMUP-1 and IMUP-2 are not known in human ovarian epithelial tumors. | Human | AKAP13 | 11214 | A kinase (PRKA) anchor protein 13 | CONCLUSION: The proto-oncogene brx is expressed in specific normal human ovarian tissues and is also present in ovarian epithelial neoplasms. | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | We show here that malignant human ovarian epithelial tumor cells express very high levels of stromal-derived factor-1, which induces DC2 precursor (preDC2) chemotaxis and adhesion/transmigration, upregulates preDC2 very late antigen (VLA)-5, and protects preDC2s from tumor macrophage interleukin-10-induced apoptosis, all through CXC chemokine receptor-4. This study was to investigate expressions of chemokine(C-X-C) receptor 4 (CXCR4) and chemokine (C-X-C motif) ligand 12 (CXCL12) in human ovarian epithelial tumor cells, and their effects on migration of tumor cells. | Human | TOP2A | 7153 | topoisomerase (DNA) II alpha 170kDa | Topoisomerase II alpha: prognostic predictor and cell cycle marker in surface epithelial neoplasms of the ovary and peritoneum. | Human | PDGFA | 5154 | platelet-derived growth factor alpha polypeptide | All six investigated ovarian epithelial tumor cell lines expressed the PDGF A- and B-chain genes, while the granulosa tumor cell line expressed the PDGF A-chain gene only. | Human | LHCGR | 3973 | luteinizing hormone/choriogonadotropin receptor | OBJECTIVES: The objective of this study was to examine the distribution and cellular localization of luteinizing hormone receptor (LHR) in ovarian epithelial tumors (OETs) and their presumed precursor lesions-ovarian epithelial inclusions (OEIs). | Human | FSHR | 2492 | follicle stimulating hormone receptor | Induction of ovarian epithelial tumors is triggered by loss of FSH receptor | Human | FGF1 | 2246 | fibroblast growth factor 1 (acidic) | Expression of aFGF, bFGF, and FGFR1 in ovarian epithelial neoplasm. | Human | FBLN1 | 2192 | fibulin 1 | Fibulin-1 expression was quantified by immunohistochemistry and computer-aided image analysis in 44 human ovarian epithelial tumors and 14 normal ovaries. Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors. | Human | ESR1 | 2099 | estrogen receptor 1 | This study evaluated 34 formalin-fixed, paraffin-embedded ovarian epithelial tumors for LOH by polymerase chain reaction (PCR) for the following microsatellite markers: TP53(17p13.1/p53 gene), D17S579(17q/BRCA1 gene), and ESR (6q24-27/estrogen receptor gene). | Human | GADD45A | 1647 | growth arrest and DNA-damage-inducible, alpha | Diagnostic approach using the expression profiling of the P53 tumor suppressor gene and its related proteins in ovarian epithelial tumors. | Human | DAB2 | 1601 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | However, in more than a dozen established tumor cell lines derived from breast and ovarian epithelial tumors examined by Western blotting, Dab2 expression was undetectable in 90% of these cell lines. | Human | RERE | 473 | arginine-glutamic acid dipeptide (RE) repeats | We performed an immunohistochemical analysis of apoptosis and the expression of apoptosis-related proteins (ARP) such as Fas and Fas ligand (FasL), bcl-2 and p53 in human ovarian epithelial tumors. Apoptosis and the apoptosis-related proteins (ARP) (Fas, Fas ligand (FasL), bcl-2 and p53) were analyzed in macrophages of different human ovarian epithelial tumors. | Human | AMH | 268 | anti-Mullerian hormone | Granulosa cells also secrete mullerian inhibiting substance (MIS), a hormone that inhibits both the formation of female reproductive organs in male embryos [] and the proliferation of ovarian epithelial tumor cells []. |
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