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Details
Link-It Detail - Disease - Pleomorphic Xanthoastrocytoma
Debug Stats
  • ### Total Build Time: 22 ms 19.351 KB
  • CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 356 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 735 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=9 ms Completed: 9 ms rowSize= 14.521 KB
  • CONCEPT_GENES gt=2 ms Completed: 2 ms rowSize= 2.530 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.163 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Pleomorphic Xanthoastrocytoma C0334586
Definition (1)
An astrocytic tumor with a relatively favorable prognosis (WHO grade II), typically encountered in children and young adults. It has a superficial location in the cerebral hemispheres and involvement of the meninges. Characteristic features include pleomorphic and lipidized cells expressing GFAP and often surrounded by a reticulin network as well as eosinophilic granular bodies. For lesions with significant mitotic activity (5 or more mitoses per 10 HPF) and/or with areas of necrosis, the designation "pleomorphic xanthoastrocytoma with anaplastic features" may be used. (WHO)
Relationships (27)

Relation Types:
diso_​to_​anat : 16
diso_​to_​diso : 10
diso_​to_​phen : 1


Relationships:
is_​abnormal_​cell_​of_​disease : 7
is_​associated_​anatomic_​site_​of : 2
is_​finding_​of_​disease : 3
is_​normal_​cell_​origin_​of_​disease : 4
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​finding_​of_​disease : 3
location_​of : 1
may_​be_​cytogenetic_​abnormality_​of_​disease : 2
may_​be_​finding_​of_​disease : 3
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Astrocytes C0004112
DISO_to_ANATlocation_ofimg Brain C0006104
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Cell, Neuroepithelial C1449624
DISO_to_ANATis_associated_anatomic_site_ofimg Central Nervous System C0927232
DISO_to_ANATis_abnormal_cell_of_diseaseimg Giant Astrocyte C1517540
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Astrocyte C1513925
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Glial Cell C1513978
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Neuroepithelial Cell C1514048
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell C1514049
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Nerve Cell, Neuroepithelial Cell, and Supporting Cell of the Nervous System C1518293
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths C1518250
DISO_to_ANATis_associated_anatomic_site_ofimg Nervous System C0027763
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Neuroepithelial Tissue C1518281
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Neuroglia C0027836
DISO_to_ANATis_abnormal_cell_of_diseaseimg Xanthomatous Astrocyte C1520165
DISO_to_DISOis_finding_of_diseaseimg Chronic lymphocytic inflammation C0333386
DISO_to_DISOis_finding_of_diseaseimg Dense Intercellular Reticulin Network Present C1511771
DISO_to_DISOmay_be_finding_of_diseaseimg Eosinophilic Granular Bodies Present C1516900
DISO_to_DISOmay_be_finding_of_diseaseimg Favorable Clinical Outcome C1333602
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg Gain of Chromosome 3 C1517409
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg Gain of Chromosome 7 C1517417
DISO_to_DISOis_not_finding_of_diseaseimg Grade 4 Lesion C1333853
DISO_to_DISOis_finding_of_diseaseimg Intracellular Accumulation of Lipids C1512921
DISO_to_DISOis_not_finding_of_diseaseimg Neuronal Differentiation C1518294
Genes (2)

Species:
human : 2
SpeciesGeneGeneIdGene NameEvidence
HumanTSC17248tuberous sclerosis 1
img GENERIF, Score=1000, Pubmed Id: 16909113, UMLKSK CUI: C0334586
HumanCDKN2B1030cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
img GENERIF, Score=1000, Pubmed Id: 16909113, UMLKSK CUI: C0334586
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0334586Pleomorphic Xanthoastrocytoma0self