Human | CLDN2 | 9075 | claudin 2 | Significant correlations sre found between claudin-2 and Cdx2 protein expression in dysplasia and intestine-type adenocarcinoma |
Human | TP53 | 7157 | tumor protein p53 | p53 genetic alterations found in gastric stump carcinomas & intestinal-type primary gastric carcinomas could originate from a similar pathway; no association found between p53 gene status & P-gp expression |
Human | CLEC3B | 7123 | C-type lectin domain family 3, member B | Of the ten cases of well-differentiated intestinal type adenocarcinomas (ITA) 4 showed moderate regional, 3 low regional and 3 negative tetranectin expression. |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Serum concentration of TIMP-1 in patients with diffuse type carcinoma was significantly higher than in patients with intestinal type carcinoma and control subjects (p < 0.05). |
Human | TFF1 | 7031 | trefoil factor 1 | In gastric carcinomas, pS2 expression was observed in 66.0% of cases, being significantly higher in diffuse (88.9%) than intestinal type carcinomas (53.6%). |
Human | SPINK1 | 6690 | serine peptidase inhibitor, Kazal type 1 | Furthermore, in the intestinal-type carcinomas, a significant correlation was observed between PSTI expression and clinical stage or nodal involvement. Of the 45 intestinal-type carcinomas, 34 cases (76%) expressed PSTI: 15 (63%) of 24 early carcinomas and 19 (90%) of 21 advanced carcinomas, the incidence being significantly different (P less than 0.05). |
Human | SOX2 | 6657 | SRY (sex determining region Y)-box 2 | In two of the four intestinal type carcinomas, MUC5AC and SOX2 were focally expressed in the superficial neoplastic mucosa. |
Human | RELA | 5970 | v-rel avian reticuloendotheliosis viral oncogene homolog A | Intestinal type gastric carcinoma is strongly associated with high expression of c-myc, cyclinD1 and bcl-xl through NF-kappaB/p65 activated by H pylori cagA |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX-2 expression might be an early event in gastric tumorigenesis and provide a advantage for tumor cell proliferation because of its vascular-rich microenvironment and escape from tumor cell apoptosis, especially in intestinal-type gastric carcinomas |
Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | p53 genetic alterations found in gastric stump carcinomas & intestinal-type primary gastric carcinomas could originate from a similar pathway; no association found between p53 gene status & P-gp expression |
Human | CD99 | 4267 | CD99 molecule | The CD99 expression was usually seen in the intestinal type adenocarcinoma, while rarely in the diffuse type. |
Human | SMAD4 | 4089 | SMAD family member 4 | expression of Smad4 was significantly lower in diffuse-type gastric adenocarcinoma than intestinal-type gastric adenocarcinomas |
Human | RPSA | 3921 | ribosomal protein SA | Intestinal type adenocarcinoma (according to Lauren;s classification) revealed a higher percentage of overexpression of the 67LR than the diffuse type in both early (p = 0.057) and advanced (p < 0.001) gastric carcinomas. |
Human | KRT7 | 3855 | keratin 7 | expressed in sinonasal intestinal-type adenocarcinoma less frequently than in colonic adenocarcinoma |
Human | GSPT1 | 2935 | G1 to S phase transition 1 | RESULTS: Different histological types of gastric tumours were analysed and nine of the 25 tumours revealed eRF3/GSPT1 overexpression; moreover, eight of the 12 intestinal type carcinomas analysed overexpressed the gene, whereas eRF3/GSPT1 was overexpressed in only one of the 10 diffuse type carcinomas (Kruskal-Wallis Test; p < 0.05). |
Human | CXCL1 | 2919 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | CXCL1 was expressed almost exclusively by diffuse- but not intestinal-type carcinoma cells. |
Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | HER-2 protein overexpression as evaluated by immunohistochemistry and HER-2 gene amplification assessed by FISH were found to be relatively common in intestinal-type gastric carcinomas |
Human | CDX2 | 1045 | caudal type homeobox 2 | marker for cellular phenotype in sinonasal intestinal-type adenocarcinoma Higher expression of Cdx2 is associated with intestinal-type carcinomas |
Human | BCL2L1 | 598 | BCL2-like 1 | In carcinomas, over-expression of the bcl-xL gene was observed in 6 of 9 intestinal-type carcinomas and 2 of 5 diffuse-type carcinomas. |