Human | BPY2C | 442868 | basic charge, Y-linked, 2C | VCY2 was weakly expressed at the spermatogonia and immunonegative in spermatocytes and round spermatids in testicular biopsy specimens with maturation arrest or hypospermatogenesis |
Human | RDH10 | 157506 | retinol dehydrogenase 10 (all-trans) | Forced over-expression of the RDH10 gene causes growth arrest of HepG2 cells and could be a possible curative strategy for hepatocellular carcinoma |
Human | ACER1 | 125981 | alkaline ceramidase 1 | upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of keratinocytes by generating sphingosine and its phosphate |
Human | KIAA1524 | 57650 | KIAA1524 | CIP2A in tumor cells is required for sustained proliferation by preventing cell growth arrest, senescence, or differentiation |
Human | HIPK2 | 28996 | homeodomain interacting protein kinase 2 | US11 of herpes simplex virus interacts with HIPK2 through the PEST domain of HIPK2 and this interaction modifies the subcellular distribution of HIPK2 and protects the cell against the HIPK2-induced cell growth arrest |
Human | HSPB8 | 26353 | heat shock 22kDa protein 8 | HspB8 overload causes melanoma growth arrest and apoptosis through TAK1 activation |
Human | PPP1R15A | 23645 | protein phosphatase 1, regulatory subunit 15A | SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein and modulated protein phosphatase-1 activity |
Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | RASSF1A may mediate its tumor suppressive effects by inducing growth arrest in the G1 and G2/M phases |
Human | PLA2G16 | 11145 | phospholipase A2, group XVI | Contact inhibition of growth and growth arrest caused by histone deacetylase inhibitors probably use the same mechanism to stimulate H-rev107 expression via histone acetylation in NIH3T3 cells |
Human | IL24 | 11009 | interleukin 24 | Establish MDA-7/IL-24 and GADD45alpha and GADD45gamma as critical mediators of apoptosis and growth arrest in response to NSAIDs in cancer cells |
Human | PDZK1IP1 | 10158 | PDZK1 interacting protein 1 | Large scale genetic screening identifies MAP17 as protein bypassing TNF-alpha-induced growth arrest |
Human | BCL10 | 8915 | B-cell CLL/lymphoma 10 | The ability of Bcl10 expression to prevent B-cell antigen receptor-induced growth arrest and apoptosis of WEHI-231 cells was dependent on NF-kappaB activation |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | Describe a novel p53 rescue compound that induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis |
Human | DDX3Y | 8653 | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | The finding that the testicular transcript of DDX3Y is significantly decreased in patients with severe spermatogenenic failure, especially in those presenting maturation arrest, suggests an important role of DDX3Y during spermatogenesis |
Human | TP63 | 8626 | tumor protein p63 | Can function as a repressor of select p53 target genes involved in growth arrest, DNA repair, and apoptosis |
Human | USP9Y | 8287 | ubiquitin specific peptidase 9, Y-linked | Our findings strongly support that the massive deletions in the AZFb or AZFb+c regions are important genetic causes of Sertoli cell only and/or maturation arrest resulting in azoospermia |
Human | NAA10 | 8260 | N(alpha)-acetyltransferase 10, NatA catalytic subunit | HIF-1alpha was found to inactivate the Wnt signaling by binding to hARD1 or beta-catenin, which may contribute to the hypoxia-induced growth arrest of tumor cells |
Human | VCP | 7415 | valosin containing protein | The findings demonstrated that monocytic differentiation and G0/G1 growth arrest in human U937 leukemia cells was accompanied by an increase in VCP/p97 expression and a distinct subcellular distribution to be reverted during retrodifferentiation |
Human | TP53 | 7157 | tumor protein p53 | Click here to display 11 evidence detail records. |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF beta 1 was able to suppress the expression of Id-1, a helix-loop-helix (HLH) protein, which plays important roles in the inhibition of cell differentiation and growth arrest |
Human | TCF21 | 6943 | transcription factor 21 | epicardin/capsulin/Pod-1 functions as a negative regulator of differentiation of myoblasts through transcription in cell growth arrest and lineage-specific differentiation |
Human | MAP3K7 | 6885 | mitogen-activated protein kinase kinase kinase 7 | HspB8 overload causes melanoma growth arrest and apoptosis through TAK1 activation |
Human | STAT5B | 6777 | signal transducer and activator of transcription 5B | in addition to growth arrest and induced differentiation, OSM also sensitizes normal and transformed osteoblasts to apoptosis by a mechanism implicating (i) activation and nuclear translocation of STAT5 and p53 and (ii) an increased Bax/Bcl-2 ratio |
Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | Stat3 activity is upregulated during the confluence-mediated growth arrest by a signalling mechanism that requires JAKs EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells |
Human | STAT1 | 6772 | signal transducer and activator of transcription 1, 91kDa | EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells |