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Genes (28)
Species: human : 28 | |
Human | VPS13B | 157680 | vacuolar protein sorting 13 homolog B (yeast) | Truncal obesity developing in mid-childhood | Human | ADIPOR1 | 51094 | adiponectin receptor 1 | Skeletal musscle expression is independently and inversely correlated with measures of central obesity | Human | PDE11A | 50940 | phosphodiesterase 11A | | Human | CAPN10 | 11132 | calpain 10 | SNP-43 of CAPN10 may contribute to the risk of diabetes by regulating abdominal obesity in subjects with high risk of type 2 diabetes | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | The adiponectin gene I164T polymorphism could be a stronger determinant of abdominal obesity with lower serum adiponectin levels, at least in Japanese women | Human | SLC7A7 | 9056 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | | Human | AIP | 9049 | aryl hydrocarbon receptor interacting protein | | Human | CUL4B | 8450 | cullin 4B | | Human | ALMS1 | 7840 | Alstrom syndrome 1 | Truncal obesity (onset in childhood) | Human | TNF | 7124 | tumor necrosis factor | TNF-alpha expression in omental adipose tissue could play a key role in contributing to cardiovascular risk in central obesity subjects Omental TNF-alpha may play a key role in contributing to cardiovascular risk in central obesity subjects abdominal obesity, adipocyte hypertrophy from visceral fat, serum TNF-alpha and C-peptide seem to be the best correlators of the lipoprotein disturbance characteristic of the metabolic syndrome | Human | SNRPN | 6638 | small nuclear ribonucleoprotein polypeptide N | | Human | PRKAR1A | 5573 | protein kinase, cAMP-dependent, regulatory, type I, alpha | | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | PPARA | 5465 | peroxisome proliferator-activated receptor alpha | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | PLIN1 | 5346 | perilipin 1 | Central obesity may modify the associations between PLIN variations and diabetes risk in women | Human | NDN | 4692 | necdin, melanoma antigen (MAGE) family member | | Human | LPL | 4023 | lipoprotein lipase | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile Results suggest that LPL gene S447X polymorphism modifies the relation between central obesity and serum lipids results suggest that the nature of the mutation in the LPL gene modifies the relationship of HDL particle size to other metabolic variables and secondary factors such as abdominal obesity and gender results suggest no association and interaction of lipoprotein lipase T+495G polymorphism with central obesity and serum lipids for all twin pairs | Human | LIPC | 3990 | lipase, hepatic | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | LEP | 3952 | leptin | study shows that serum leptin levels are directly related to 24-hour blood pressure levels in normotensive women with android fat distribution | Human | IL1B | 3553 | interleukin 1, beta | in a coronary heart disease population IL-1 alpha and beta gene polymorphisms may be involved in increased central obesity, and the genetic influences are more evident among patients who have a higher level of obesity or inflammatory markers | Human | IL1A | 3552 | interleukin 1, alpha | in a coronary heart disease population IL-1 alpha and beta gene polymorphisms may be involved in increased central obesity, and the genetic influences are more evident among patients who have a higher level of obesity or inflammatory markers | Human | NR3C1 | 2908 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Title:Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Qu????bec Family Study.|Association:Y|Conclusion:There is an association between the GRL BclI polymorphism and increased AVF levels independent of the level of total body fat. The alpha 2-ADR DraI variant is associated with a lower cross-sectional area of abdominal total fat. Numerous interactions between GRL and ADR markers on overall adiposity and total abdominal fat as well as between GRL, LPL and ADR genes on overall adiposity, abdominal total and visceral fat suggest that the genetic architecture of body fat content and adipose tissue distribution is complex although some genes, like GRL, may have ubiquitous effects. Glucocorticoid receptor polymorphism is associated with major depression and greater abdominal obesity | Human | CYP19A1 | 1588 | cytochrome P450, family 19, subfamily A, polypeptide 1 | results indicate that, in premenopausal women, a short microsatellite in the fourth intron of the CYP19 gene is associated with elevated androgens, perturbed regulation of the hypothalamic-pituitary-adrenal axis, and abdominal obesity | Human | COMT | 1312 | catechol-O-methyltransferase | Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men | Human | CNR1 | 1268 | cannabinoid receptor 1 (brain) | CNR1 gene polymorphism is associated with central obesity in this Brazilian population of European ancestry |
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