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Details
Link-It Detail - Disease - Aphasia, Primary Progressive
Debug Stats
  • ### Total Build Time: 51 ms 22.146 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 422 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 655 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 201 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=6 ms Completed: 6 ms rowSize= 969 bytes
  • CONCEPT_CHILDREN gt=6 ms Completed: 6 ms rowSize= 575 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=12 ms Completed: 12 ms rowSize= 7.905 KB
  • CONCEPT_RELATIONSHIPS gt=10 ms Completed: 10 ms rowSize= 6.112 KB
  • CONCEPT_GENES gt=7 ms Completed: 7 ms rowSize= 4.184 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.162 KB
  • CONCEPT_ANCILLARY gt=2 ms Completed: 2 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Aphasia, Primary Progressive C0282513
Primary Progressive Aphasia (disorder)
Definition (1)
A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)
Semantic Types (1)
Mental or Behavioral Dysfunction (T048)
Parents (2)
img Dementia C0497327
img Aphasia C0003537
Children (1)
img Primary Progressive Nonfluent Aphasia C0751706
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Dementia C0497327
img Mental Disorders C0004936img Delirium, Dementia, Amnestic, Cognitive Disorders C00292274img Dementia C0497327
img Mental Disorders C0004936img Mental Disorders Diagnosed in Childhood C05250407img Aphasia C0003537
img Nervous System Diseases C0027765img Neurologic Manifestations C00278548img Aphasia C0003537
img Pathological Conditions, Signs and Symptoms C0039058img Signs and Symptoms C00370889img Aphasia C0003537
img Behavior and Behavior Mechanisms C0004928img Neurobehavioral Manifestations C05250417img Aphasia C0003537
Relationships (13)

Relation Types:
diso_​to_​anat : 3
diso_​to_​diso : 8
diso_​to_​phen : 2


Relationships:
none : 10
expanded_​form_​of : 1
isa : 1
related_​to : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANAT24img Brain C0006104
DISO_to_PHEN24img genetic aspects C0017399
DISO_to_DISO20img Complication Aspects C1171258
DISO_to_DISO18img Dementia C0497327
DISO_to_DISO14img Alzheimer Disease C0002395
DISO_to_DISO12img Dementia C0497327
DISO_to_DISO9img Complication Aspects C1171258
DISO_to_ANAT8img Brain C0006104
DISO_to_PHEN8img genetic aspects C0017399
DISO_to_ANAT7img Cerebral Cortex C0007776
DISO_to_DISOexpanded_form_ofimg Aphasia, Primary Progressive C0282513
DISO_to_DISOisaimg Aphasia, Progressive Nonfluent C0751706
DISO_to_DISOrelated_toimg DEMENTIA, HEREDITARY DYSPHASIC DISINHIBITION C1843792
Genes (3)

Species:
human : 3
SpeciesGeneGeneIdGene NameEvidence
HumanPRNP5621prion protein
img GENERIF, Score=1000, Pubmed Id: 16315279, UMLKSK CUI: C0282513
HumanMAPT4137microtubule-associated protein tau
img GAD, Score=1000, Pubmed Id: 12629248, UMLKSK CUI: C0282513
HumanGRN2896granulin
img GENERIF, Score=1000, Pubmed Id: 17522386, UMLKSK CUI: C0282513
img GENERIF, Score=1000, Pubmed Id: 17210807, UMLKSK CUI: C0282513
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0282513Aphasia, Primary Progressive0self