Human | NOX5 | 79400 | NADPH oxidase, EF-hand calcium binding domain 5 | Acid-induced NOX5-S expression is mediated by platelet activating factor and STAT5 in esophageal adenocarcinoma cells |
Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | Results describe cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma |
Human | RPRM | 56475 | reprimo, TP53 dependent G2 arrest mediator candidate | Promoter methylation of Reprimo was found in 79% of gastric cancers, 62% of gallbladder cancers, 57% of lymphomas, 56% of colorectal cancers, 40% of esophageal adenocarcinomas, 37% of breast cancers and 31% of leukemias. |
Human | TNFRSF12A | 51330 | tumor necrosis factor receptor superfamily, member 12A | Fn14 protein expression increased with disease progression in esophageal adenocarcinoma |
Human | ADIPOR1 | 51094 | adiponectin receptor 1 | Data show that globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation.( |
Human | NUDT6 | 11162 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | The aim of this study was to characterize the expression of alternatively spliced FGF-AS transcripts and encoded nudix-motif proteins in normal human tissues and in esophageal adenocarcinoma |
Human | UBE2C | 11065 | ubiquitin-conjugating enzyme E2C | Transfection of dominant-negative UBE2C into Seg-1 esophageal adenocarcinoma cells decreases proliferation and increased mitotic arrest compared to vector controls |
Human | NR1H4 | 9971 | nuclear receptor subfamily 1, group H, member 4 | The bile acid receptor FXR is significantly overexpressed in Barrett's esophagus compared to normal mucosa, esophagitis and esophageal adenocarcinoma |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Data show that globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation.( |
Human | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | The aim of this work was to determine whether RANK is expressed in oesophageal adenocarcinoma (EA) and its precursor, Barrett;s metaplasia (BM). |
Human | TNFRSF6B | 8771 | tumor necrosis factor receptor superfamily, member 6b, decoy | significantly more overexpression of DcR3 in high-grade dysplasia or carcinoma in situ and esophageal adenocarcinoma Using M68 immunohistochemistry and a scoring system similar to that used for HER-2/neu, we found that M68 protein was overexpressed in 30 of 68 (44%) human adenocarcinomas of the esophagus, stomach, colon, and rectum. Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus. |
Human | TFPI2 | 7980 | tissue factor pathway inhibitor 2 | TFPI-2 promoter methylation was observed in one of five pulmonary adenocarcinomas, and seven of seven esophageal adenocarcinomas, but not corresponding normal tissues. |
Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | No significant association between the XRCC1 ARG339Gln polymorphism and the risk of esophageal adenocarcinoma, Barrett's esophagus or reflux esophagitis The XRCC1 Arg399Gln polymorphism did modify the relationship between XPD Lys751Gln and esophageal adenocarcinoma risk |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Gene expression data suggest that pharmacologic inhibition of COX-2 and VEGF may be useful adjuncts in targeted therapy for esophageal adenocarcinoma c-myc and VEGFA may be involved in the regulation of angiogenesis in esophageal adenocarcinoma cigarette smoking modifies the association between VEGF polymorphisms and esophageal adenocarcinoma risk among Caucasians |
Human | TSC1 | 7248 | tuberous sclerosis 1 | Inflammation-associated signaling pathway involving TSC1 is activated in Barret's esophagus esophaggeeal adenocarcinoma |
Human | HSP90B1 | 7184 | heat shock protein 90kDa beta (Grp94), member 1 | We could demonstrate an association of GRP78 and GRP94 mRNA and protein expression with tumor stage and behaviour in esophageal adenocarcinomas |
Human | TP53 | 7157 | tumor protein p53 | decreased cell-surface expression of Fas and resistance to Fas-mediated apoptosis may occur independently of loss of wt p53 expression in esophageal adenocarcinoma study showed higher frequency of p53 mutations in esophageal adenocarcinoma (EAC)than previously reported, but only as a late event in carcinogenesis; 72R allelic polymorphism was of potential significance in the development of Barrett esophagus &/or EAC |
Human | TIMP3 | 7078 | TIMP metallopeptidase inhibitor 3 | Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barretts oesophageal adenocarcinoma. Reduced expression of TIMP-3 protein in esophageal adenocarcinoma is associated with increased tumour invasiveness |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barretts oesophageal adenocarcinoma. |
Human | TGFBI | 7045 | transforming growth factor, beta-induced, 68kDa | Nine genes were up-regulated in oesophageal adenocarcinoma tissue (matrix metalloproteinase 11 (MMP11), ornithine decarboxylase (ODC), cytokeratins 8 and 18, integrin alpha 3 (ITGA3), integrin alpha 6 (ITGA6), BIGH3 (transforming growth factor beta-induced), beta-catenin and CDC25B (M-phase inducer phosphatase 2)). |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta1 overexpression is associated with advanced stage of esophageal adenocarcinoma and implies a negative impact on survival |
Human | SPARC | 6678 | secreted protein, acidic, cysteine-rich (osteonectin) | These findings suggest that the upregulation of SPARC mRNA expression is an early event in the development and progression of BE and EA, and that high SPARC expression may be a clinically useful biomarker for the detection of occult adenocarcinoma, and that a widespread field effect is present in the NE of patients with oesophageal adenocarcinoma. |
Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | SNPs involving the GSTP1, MnSOD and GPX2 genes were not associated with Barrett's esophagus or esophageal adenocarcinoma |
Human | SLC1A4 | 6509 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | These results suggest that unlike in squamous cell carcinoma, ASCT1 plays a significant role in the recruitment of amino acids in adenocarcinoma of the esophagus, and suggest that the metabolic needs, and uptake of nutrients, are regulated differently in these two tumor types. |
Human | SFRP1 | 6422 | secreted frizzled-related protein 1 | Inactivating SFRP1 methylation occurred in all Barrett esophagus samples and in 96% of esophageal adenocarcinomas |