Genes (134)
Species: human : 133 mouse : 1 | |
Mouse | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | Selection of monoclonal antibody E48 IgG or U36 IgG for adjuvant radioimmunotherapy in head and neck cancer patients. | Human | CSMD2 | 114784 | CUB and Sushi multiple domains 2 | CSMD2 maps to a chromosomal region that may contain a suppressor of oligodendrogliomas, yet its expression is elevated in some head and neck cancer cell lines. | Human | ABCC10 | 89845 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma | Human | CYSLTR2 | 57105 | cysteinyl leukotriene receptor 2 | Together, our results demonstrate the importance of a mechanism that promotes head and neck cancer cell proliferation and motility by GPCR ligands involving EGFR transactivation. | Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | We found CpG methylation-dependent silencing of CHFR expression in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers. | Human | ING3 | 54556 | inhibitor of growth family, member 3 | Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. We previously showed two members of the ING family, ING1 and ING3 as a tumor suppressor gene in head and neck cancer. ING3 would function as a potential tumor suppressor molecule and that low levels of ING3 may indicate an aggressive nature of head and neck cancer Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers | Human | TLR7 | 51284 | toll-like receptor 7 | Up-regulation of natural killer cell function against head and neck cancer in response to single-stranded immunostimulatory RNA requires TLR7 | Human | ING4 | 51147 | inhibitor of growth family, member 4 | Frequent deletion and decreased mRNA expression of ING4 suggested it as a class two tumor suppressor gene and may play an important role in head and neck cancer | Human | CTAG2 | 30848 | cancer/testis antigen 2 | Expression of LAGE-I was observed in 25-50% of tumor samples of melanomas, non-small-cell lung carcinomas, bladder, prostate and head and neck cancers. | Human | BBC3 | 27113 | BCL2 binding component 3 | PUMA in head and neck cancer. | Human | LY96 | 23643 | lymphocyte antigen 96 | In the present study, we first examined the effect of OK-PSA on the maturation of dendritic cells (DCs) in vitro by using the DCs derived from 5 healthy donors and 10 patients with head and neck cancer with or without expression of toll-like receptor 4 (TLR4) or MD-2 mRNA. | Human | STAB1 | 23166 | stabilin 1 | Affinity of the tested head and neck cancer cell lines to the lymphatic endothelium varied greatly, but adhesion of all cell lines was dependent on both the MR and CLEVER-1. | Human | KLRK1 | 22914 | killer cell lectin-like receptor subfamily K, member 1 | This novel combination strategy holds promise for the treatment of head and neck cancer, and the mechanism of NKG2D in activating natural killer and CTL receptors provides a foundation for additional investigation, and development of immune modulation and chemotherapy regimens. | Human | OGFR | 11054 | opioid growth factor receptor | Gene therapy to reinstate more OGFr and enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression in head and neck cancers | Human | COPS5 | 10987 | COP9 signalosome subunit 5 | These findings suggest that p27Kip1 mt, Skp2 AS and Jab1 AS have the potential to become a novel and powerful gene therapy tool, and that stability of p27Kip1 protein may improve therapeutic benefits to patients with head and neck cancer. Human head and neck cancer (HNt and HSY) cells expressed p27Kip1, Skp2 and Jab1. To determine the function of p27Kip1, Skp2 and Jab1, we transfected head and neck cancer cells with pcDNA3.1-p27Kip1 wt, pcDNA3.1-p27Kip1 mt or treated with Skp2 antisense oligonucleotide (AS) or Jab1 AS. | Human | LYVE1 | 10894 | lymphatic vessel endothelial hyaluronan receptor 1 | To address the issue we quantitated tumor lymph vessels in archival specimens of head and neck cancer by immunostaining for the recently described lymphatic endothelial marker LYVE-1, the vascular endothelial marker CD34, and the pKi67 proliferation marker, correlating lymph vessel density and proliferation index with clinical and pathological variables. | Human | GJB6 | 10804 | gap junction protein, beta 6, 30kDa | Cx30 expression in head and neck cancer was drastically reduced compared to apparently normal mucosa while Cx26 expression was almost the same | Human | POSTN | 10631 | periostin, osteoblast specific factor | Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer. | Human | CCNA1 | 8900 | cyclin A1 | Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. | Human | TNFRSF10B | 8795 | tumor necrosis factor receptor superfamily, member 10b | Mutations of TRAIL-R2 have been detected in lung cancer, breast cancer, head and neck cancer, and non-Hodgkins lymphoma. We have determined the genomic structure of KILLER/DR5 and performed sequence analysis of all 10 coding exons in 20 primary head and neck cancers with allelic loss of chromosome 8p. We previously reported that KILLER/DR5 can be mutationally inactivated in head and neck cancer. | Human | ABCC3 | 8714 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | The cMOAT2/MRP3 gene was not overexpressed in cisplatin-resistant cell lines with increased ATP-dependent transport of cisplatin over their parental counterparts derived from human head and neck cancer and human prostatic cancer cell lines. | Human | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | Click here to display 22 evidence detail records. | Human | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Ku80 expression may provide an effective predictive assay of radiosensitivity in head and neck cancers. | Human | XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3 | Pooling data and DNA specimens from three case-control studies in western Washington State, North Carolina, and Puerto Rico, totaling 555 cases (430 whites) and 792 controls (695 whites), we studied the risk of head and neck cancer in relation to common nonsynonymous single-nucleotide polymorphisms in four DNA repair genes: MGMT (Leu(84)Phe and Ile(143)Val), XRCC1 (Arg(399)Gln), XPD (Lys(751)Gln), and XRCC3 (Thr(241)Met). Title:Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: apooled analysis.|Association:Not Found|Conclusion: Selected Genetic Polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and Risk of Head and Neck Cancer: A Pooled Analysis. | Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | Title:Association of DNA repair gene XRCC1 polymorphisms with head and neck cancer in Korean population.|Association:Y|Conclusion:When considering a relatively small number of cases (n = 147) and controls (n = 168) in our study, larger studies are needed to validate the genetic effects of XRCC1 polymorphisms in Asian populations. In conclusion, the result from our study provides additional evidence of an association of the XRCC1 polymorphism (Arg194Trp) with SCCHN as markers of genetic susceptibility in the Korean population. Title:Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: apooled analysis.|Association:Not Found|Conclusion: Title:Genetic susceptibility--molecular epidemiology of head and neck cancer.|Association:Not Found|Conclusion:Review article |
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