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Genes (108)
Species: human : 108 | |
Human | MIR10B | 406903 | microRNA 10b | microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion | Human | MUCL1 | 118430 | mucin-like 1 | The SBEM gene is predicted to code for a putative low molecular weight, secreted sialoglycoprotein, potentially useful for the diagnosis of metastatic breast cancer. | Human | MTDH | 92140 | metadherin | This domain is part of the protein metadherin, shown by gene expression profiling to be overexpressed in metastatic breast cancer. overexpression of metadherin is associated with metastatic breast cancer | Human | TUBA1C | 84790 | tubulin, alpha 1c | Because these agents bind to distinct sites on tubulin and affect microtubules in opposite ways, a pilot study was conducted of the combination of vinorelbine and paclitaxel in patients with metastatic breast cancer or lung cancer who were refractory to first-line chemotherapy. | Human | PPP1R1B | 84152 | protein phosphatase 1, regulatory (inhibitor) subunit 1B | Thus, DARPP-32 signaling downstream of DDR1 is a potential new target for effective anti-metastatic breast cancer therapy | Human | PVRL4 | 81607 | poliovirus receptor-related 4 | In vivo, Nectin-4 is re-expressed in breast carcinoma, and a circulating form of Nectin-4 is detected in the sera of patients with metastatic breast cancer. | Human | MUC3B | 57876 | mucin 3B, cell surface associated | DESIGN: Mucosal biopsy specimens from 47 adenocarcinomas involving the gastrointestinal tract (28 primary gastric carcinomas and 19 metastatic breast carcinomas) and 16 control cases of primary breast carcinomas without metastasis were immunohistochemically stained for estrogen receptor protein (ER), progesterone receptor protein (PR), gross cystic disease fluid protein (GCDFP), human epidermal growth factor receptor 2 protein, cytokeratin (CK) 5/6, CK/7, CK/20, a panel of mucin glycoprotein antigens (MUC2, MUC3, MUC5AC, and MUC6), monoclonal antibody DAS-1, and caudal-type homeobox transcription factor CDX2 and compared between primary and metastatic adenocarcinomas. | Human | LASS2 | 29956 | | The sections from paraffin-embedded blocks of human cancer (52 cases of breast carcinoma and 41 cases of colon cancer) were stained, showing strongly positive in non-metastatic tumor and weakly positive or negative in metastatic tumor; the strongly positive rate of TMSG-1 expression in human cancers were, respectively, 36%, 7.4%, 52.4%, and 35% in non-metastatic and metastatic breast cancer and non-metastatic and metastatic colon cancer (p = 0.02). | Human | BRMS1 | 25855 | breast cancer metastasis suppressor 1 | The breast cancer metastasis-suppressor gene BRMS1 is downregulated in metastatic breast cancer cells. | Human | SLC39A6 | 25800 | solute carrier family 39 (zinc transporter), member 6 | Investigation of the protein product of the oestrogen-regulated gene LIV-1, implicated in metastatic breast cancer, has revealed 10 protein sequences of unknown function that belong to a new family with potential to control intracellular Zn2+ homeostasis. There are now recognised to be four subfamilies of the ZIP transporters, including the recently discovered LIV-1 subfamily which has similarity to the oestrogen-regulated gene LIV-1, previously implicated in metastatic breast cancer. | Human | SASH1 | 23328 | SAM and SH3 domain containing 1 | We therefore hypothesize that other mechanisms as for instance methylation of the promoter region of SASH1 are responsible for the loss of expression of SASH1 in primary and metastatic breast cancer. | Human | DKK1 | 22943 | dickkopf WNT signaling pathway inhibitor 1 | Increased Dickkopf-1 expression is associated with breast cancer bone metastases | Human | PPARGC1A | 10891 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | Down-regulation of peroxisome-proliferator activated receptor-gamma coactivator 1 is associated with local recurrence and metastasis in breast cancer | Human | TXNIP | 10628 | thioredoxin interacting protein | In response to glucose, increased level of TXNIP RNA is followed by increased level of protein that is associated with increasing levels of reactive oxygen species (ROS) and reduced thioredoxin activity in a metastatic breast cancer-derived cell line | Human | GPNMB | 10457 | glycoprotein (transmembrane) nmb | Osteoactivin was identified as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone | Human | TNK2 | 10188 | tyrosine kinase, non-receptor, 2 | TNK2 enhanced migration and invasion of breast cancer cells by preserving EGFR expression, inspite of its previously reported signalling via BCAR1, explaining its oncogenic behaviour in vitro and correlation with metastatic human breast cancer in vivo | Human | BCAR1 | 9564 | breast cancer anti-estrogen resistance 1 | Thus, measurement of Bcar1/p130Cas may provide useful prognostic information for patients with primary or metastatic breast cancer. | Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | Highest securin expression was seen in brain metastatic breast tumors (4.3-fold, P<0.01), cells derived from metastatic breast cancers (6.5-fold, P<0.001), and in invasive ductal carcinoma (mean+/-s.e.: 3.8-fold, P<0.001). | Human | TNFRSF10B | 8795 | tumor necrosis factor receptor superfamily, member 10b | Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers. | Human | IRS2 | 8660 | insulin receptor substrate 2 | This review points out that IRS-2, which is implicated in mediating signals to promote tumor cell survival, growth and motility, is a positive regulator of breast cancer metastasis | Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | osteoprotegerin and RANK ligand have roles in breast cancer bone metastasis | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | Click here to display 6 evidence detail records. | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | Moreover, in six patients 6-60% of MUC1-secreting cells also expressed the CXCR4 chemokine receptor, which is involved in the homing of metastatic breast cancer cells. These data indicate that CXCR4 is required to initiate proliferation and/or promote survival of breast cancer cells in vivo and suggest that CXCR4 inhibitors will improve treatment of patients with primary and metastatic breast cancer. CXCR4 regulates growth of both primary and metastatic breast cancer. To analyze effects of CXCR4 on metastases to the lung, an organ commonly affected by metastatic breast cancer, we injected tumor cells intravenously and monitored cell growth with bioluminescence imaging. | Human | YES1 | 7525 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells which was simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway | Human | XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3 | XRCC1-01, XRCC3-01, and CCND1-01 may be predictive of survival outcome in patients with metastatic breast cancer treated with DNA-damaging chemotherapy |
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