Human | LOC100507436 | 100507436 | | Title:Microsatellite allele A5.1 of MHC class I chain-related gene A is associated with latent autoimmune diabetes in adults in Latvia.|Association:Y|Conclusion:We conclude that (a) MICA allele A5.1 is associated with LADA and (b) MICA may play an important role in the etiopathogenesis of LADA. |
Human | SUMO4 | 387082 | small ubiquitin-like modifier 4 | study of the prevalence of four polymorphisms,CTLA-4 -318 C/T, 159 C/T, 3' STR and SUMO4 163 AG in latent autoimmune diabetes in adults; no association with either of the polymorphisms has been found |
Human | PTPRVP | 148713 | protein tyrosine phosphatase, receptor type, V, pseudogene | Transgenic mice lacking protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in islet beta-cell proliferation, insulin secretion, and insulin sensitivity |
Human | FTO | 79068 | fat mass and obesity associated | FTO is a strong influential gene in polycystic ovary syndrome and correlated to various components of MetS including obesity, IFG, glucose intolerance and insulin resistance |
Human | TNMD | 64102 | tenomodulin | Polymorphisms are associated with adiposity and also with glucose metabolism and conversion from glucose intolerance to type 2 diabetes |
Human | RETN | 56729 | resistin | association sith resristin concentrstion and body composition in glucose intolerance and type 2 diabetes |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Several ghrelin gene variations were associated with blood pressure levels in subjects with impaired glucose tolerance |
Human | NEUROG3 | 50674 | neurogenin 3 | Polymorphism contributes to glucose intolerance in a South Indian population |
Human | POLG2 | 11232 | polymerase (DNA directed), gamma 2, accessory subunit | Impaired glucose tolerance |
Human | PPARGC1A | 10891 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 482Ser allele of the PGC-1alpha gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial Single nucleotide polymorphisms in PPARD modify the conversion from glucose intolerance to type 2 diabetes particularly in combination with polymorphisms in PGC-1A |
Human | ZMPSTE24 | 10269 | zinc metallopeptidase STE24 | |
Human | NAMPT | 10135 | nicotinamide phosphoribosyltransferase | The results indicate that hyperglycemia causes an increase in plasma visfatin levels and, as in people with diabetes mellitus type 2 but not with impaired glucose tolerance, this increase gets more prominent as the glucose intolerance worsens |
Human | ARHGEF11 | 9826 | Rho guanine nucleotide exchange factor (GEF) 11 | R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Impaired glucose tolerance (IGT) subjects had lower plasma adiponectin levels compared with normal(NGT) subjects The severity of glucose intolerance in women with previous gestational diabetes mellitus is associated with high RBP4 and low adiponectin concentrations Both circulating adiponectin levels and the portion present as the most active HMW form are reduced in polycystic ovary syndrome, with differences related to the degree of glucose intolerance and insulin resistance Patients with impaired glucose tolerance (IGT) had significantly lower adiponectin levels than those with normal glucose tolerance; plasma adiponectin levels were associated with IGT in multiple logistic regression analysis single nucleotide polymorphism SNP276 of the adiponectin gene may affect impaired glucose tolerance and hypoadiponectinemia Low plasma levels of adiponectin is one of several independent predictors of glucose intolerance in a Japanese-Brazilian population Single nucleotide polymorphisms of the adiponectin gene as predictors for the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial, are evaluated |
Human | AIP | 9049 | aryl hydrocarbon receptor interacting protein | Impaired glucose tolerance |
Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | May have a protective effect in protecting vasodilation in glucose intolerance |
Human | TNFRSF1A | 7132 | tumor necrosis factor receptor superfamily, member 1A | Impaired glucose tolerance is not associated with increased serum concentrations inversely related to endothelium-dependent vaodilation in glucose intolerance |
Human | TNF | 7124 | tumor necrosis factor | Promoter polymorphism in this gene predicts the conversion from impaired glucose tolerance to type 2 diabetes Serum pro-inflammatory cytokine IL-6 or TNF-alpha concentrations were neither increased in subjects with impaired glucose tolerance nor closely correlated with the components of the metabolic syndrome |
Human | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | The higher homeostasis model assessment insulin resistance index (HOMA-B%) index in TT-homozygotes indicates TCF7L2 to be a susceptibility gene for the development of impaired glucose tolerance in obese children Common variants (rs12255372 and rs7903146) in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance |
Human | HNF1B | 6928 | HNF1 homeobox B | Impaired glucose tolerance |
Human | ABCC8 | 6833 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | Polymorphisms of SUR1 gene predicted conversion from impaired glucose tolerance to type 2 diabetes, and the effect of these polymorphisms on diabetes risk was additive with E23K polymorphism of Kir6.2 gene |
Human | STX1A | 6804 | syntaxin 1A (brain) | A lower frequency of the PRM -352T allele of the STX1A gene in overweight/obese subjects impaires glucose regulation, particularly among individuals with combined glucose intolerance and overt diabetes |
Human | SLC2A4 | 6517 | solute carrier family 2 (facilitated glucose transporter), member 4 | Our findings implicate the muscular GLUT4 system in the glucose intolerance of liver cirrhosis by a mechanism different from that in diabetes |
Human | SLC2A2 | 6514 | solute carrier family 2 (facilitated glucose transporter), member 2 | SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with impaired glucose tolerance |
Human | SCG5 | 6447 | secretogranin V (7B2 protein) | SGNE1 genetic variation does not contribute to obesity and common forms of Type 2 diabetes but may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity |