Genes (81)
Species: human : 80 mouse : 1 | |
Mouse | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | The E 48 antigen, which is formaldehyde resistant, appears to be a reliable marker for differentiation of squamous cell carcinomas from adenocarcinoma, and small cell carcinomas. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | On the other hand, little or no GGT was demonstrable in four epidermoid carcinomas and one oat cell cancer. | Human | CD109 | 135228 | CD109 molecule | When CD109 expression was examined in 33 cases of human lung cell carcinomas by quantitative RT-PCR, a significant high expression of CD109 was detected in about half of squamous cell carcinomas examined, but not in adenocarcinoma, large-cell carcinoma and small-cell carcinoma. | Human | TUBA1C | 84790 | tubulin, alpha 1c | In neuroendocrine tumours, two of seven (28%) carcinoids, two of seven (28%) atypical carcinoids and seven of 10 (70%) small cell carcinomas were strongly positive for tubulin. | Human | KRT20 | 54474 | keratin 20 | GPC3 is frequently expressed in noncutaneous small cell neuroendocrine carcinoma of various origins, in particular in Merkel cell carcinoma, which, in combination with CK20 | Human | PLUNC | 51297 | | The findings suggest that SPLUNC1 is commonly expressed in adenocarcinomas, muco-epidermoid carcinoma, and bronchio-alveloar carcinoma, and is absent from small-cell carcinoma and squamous cell carcinoma. | Human | F11R | 50848 | F11 receptor | Effect of gene on proliferation arrest in a non-small cell bronchopulmonary cancer line | Human | GCAT | 23464 | glycine C-acetyltransferase | effect of gene on proliferation arrest in a non-small cell bronchopulmonary cancer line | Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | | Human | LZTS1 | 11178 | leucine zipper, putative tumor suppressor 1 | To elucidate the role of FEZ1 in lung cancer, we have analyzed its expression by immunohistochemistry in 103 primary lung cancer specimens including 98 non-small cell lung cancers (57 adenocarcinomas, 32 squamous cell carcinomas, 7 large cell carcinomas, and 2 others) and five small cell carcinomas. | Human | RIPK3 | 11035 | receptor-interacting serine-threonine kinase 3 | Further analysis of primary tumors indicated that the frequency of hypermethylation was high for ASC (82%) and PAX3 (86%) in all tumor types, and high for RIPK3 in small cell carcinoma (57%). | Human | IGF2BP3 | 10643 | insulin-like growth factor 2 mRNA binding protein 3 | Immunohistochemical detection of KOC expression may be a useful diagnostic tool for distinguishing between small cell carcinoma and carcinoid tumor | Human | MSLN | 10232 | mesothelin | Mesothelin was present in more than half (53%) of adenocarcinomas and a minority (13%) of large cell carcinomas but was absent in small cell carcinomas. | Human | DLEC1 | 9940 | deleted in lung and esophageal cancer 1 | | Human | SV2A | 9900 | synaptic vesicle glycoprotein 2A | We studied the immunoreactivity to six CgA epitopes and SV2 in ten typical (TC) and ten atypical (ACT) carcinoids, five large-cell NE carcinomas (LCNEC) and five small-cell carcinomas (SCLC), also comparing the results with clinicopathological characteristics of tumors. | Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | Immunohistochemical analysis revealed the relationship between RCAS1 expression and clinicopathological variables (age, sex, smoking, histology, differentiation grade, pathological T factor, N factor and stage) and the prognostic significance of RCAS1 in 66 lung-cancer patients who underwent curative operations: 33 adenocarcinomas, 24 squamous-cell carcinomas, 3 large-cell carcinomas, 4 adenosquamous carcinomas and 2 small-cell carcinomas. | Human | TP63 | 8626 | tumor protein p63 | Pulmonary neuroendocrine tumors also show p63 staining in some instances, particularly in higher-grade tumors, and the majority of small cell carcinomas are p63-positive. All small-cell carcinomas were p63 negative (n = 9). Of 28 small cell carcinomas, 26 (93%) small cell carcinomas showed diffuse moderate or strong staining for thyroid transcription factor-1 with no staining for high molecular weight keratin and p63. Formalin-fixed paraffin-embedded tissue sections of small cell carcinomas and poorly differentiated squamous cell carcinomas underwent immunohistochemical staining with antibodies to thyroid transcription factor-1, p63, high molecular weight keratin, and p16(INK4A). In the neuroendocrine tumors, an increasing proportion of tumors stained for p63 as tumor grade increased; 1.9% of classic carcinoids, 30.8% of atypical carcinoids, 50% of large cell neuroendocrine carcinomas, and 76.9% of small cell carcinomas were positive. This study demonstrates that a panel consisting of antibodies to thyroid transcription factor-1, p63, high molecular weight keratin, and p16(INK4A) is highly effective for distinguishing between small cell carcinoma and poorly differentiated squamous cell carcinoma. p63 immunostaining may also aid in some histopathologic distinctions, such as in small biopsies where the differential diagnosis is poorly differentiated squamous carcinoma versus small-cell carcinoma. The p53 homologous squamous stem-cell regulatory protein p63 is expressed in squamous carcinomas but is not characteristically detected in small-cell carcinomas (SCCs). | Human | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | The E 48 antigen, which is formaldehyde resistant, appears to be a reliable marker for differentiation of squamous cell carcinomas from adenocarcinoma, and small cell carcinomas. | Human | TTF1 | 7270 | transcription termination factor, RNA polymerase I | In stage III non-small cell lun cancer, there was a significant association between TTF-1 and EGFR or TTF-1 and Mdm2 | Human | TP53 | 7157 | tumor protein p53 | DNA hypermethylation of p53 was detected in a quarter of the low-grade, low-stage transitional cell carcinomas(TCC) and undifferentiated small cell carcinomas, but only sporadically in squamous cell carcinomas, and was absent in high-grade, high-stage TCC | Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | The present study evaluates in three lung cancer cell lines (small cell carcinoma NCI-H69, adenocarcinoma A-427, squamous carcinoma SK-MES-1) and one erythroleukaemia (K-562) cell line the following evasion mechanisms: (1) inhibition of TNF-alpha production, in indirect and direct co-cultures with monocytes; (2) the expression of type I and type II receptors for TNF-alpha (TNFRI and TNFRII) by tumour cell lines, using indirect immunofluorescence and flow cytometry; (3) the sensitivity of tumour cell lines to the toxic action of recombinant human TNF-alpha (rhTNF-alpha). | Human | NKX2-1 | 7080 | | Click here to display 29 evidence detail records. | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | The aggressive clinical behavior of small cell carcinoma may be attributable, at least in part, to a loss of the inhibitory effect of TIMP-2, as a significant proportion of these tumors showed negative or low levels of TIMP-2 expression. TIMP-2 was also expressed at high levels except in the small cell carcinomas, which showed TIMP-2 expression at a lower frequency (60%) compared with other types of lung tumors (80% to 100%). In the present study, the authors evaluated immunohistochemically the expression of gelatinase A; tissue inhibitor of metalloproteinases-2 (TIMP-2), an inhibitor of gelatinase A; matrilysin; and trypsin(ogen) in 67 lung tumors from a variety of histological types including 17 squamous cell carcinomas, 16 adenocarcinomas, 15 small cell carcinomas, and 12 carcinoids. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | TIMP-1 was observed in the media of all cells as a 21-kD band, and as TIMP-1 polymers with the exception of the small-cell carcinoma samples. | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta1 polymorphisms and their haplotypes is associated with adenocarcinoma and small cell carcinoma of the lung |
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