Human | MYLK2 | 85366 | myosin light chain kinase 2 | MYLK gene is a risk factor for the development of acute lung injuries |
Human | ACE2 | 59272 | angiotensin I converting enzyme 2 | data identify a critical function for ACE2 in acute lung injury |
Human | SNX12 | 29934 | sorting nexin 12 | Metallothionein deficient mice have a marked decrease in Snx12 during acute lung injury |
Human | RNF13 | 11342 | ring finger protein 13 | Mice lacking Mt1/2 have a rapid decrease in Rnf13 during acute lung injury |
Human | NAMPT | 10135 | nicotinamide phosphoribosyltransferase | PBEF contributes to acute lung injury susceptibility These results may reveal a novel role of PBEF in the pathogenesis of acute lung injury; it interacts with ND1, IFITM3, and ferritin light chain involved in oxidative stress and inflammation |
Human | YWHAB | 7529 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | Tyrosine 3-monooxygenase/tryptophan S-monooxygenase activation protein, beta polypeptide is decreased during acute lung injury more in mice deficient in metallothionein 1/2 |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | TIMP1 transcripts increased during acute lung injury in mice |
Human | THBS1 | 7057 | thrombospondin 1 | Transcripts for THBS1, an activator of TGF-Beta, increased during acute lung injury in mice |
Human | SPP1 | 6696 | secreted phosphoprotein 1 | SPP1 mRNA increases during acute lung injury in mice |
Human | CCL17 | 6361 | chemokine (C-C motif) ligand 17 | Circulating TARC/CCL17 and KL-6 are useful measurements for discriminating acute eosinophilic pneumonia from other causes of acute lung injury |
Human | PLAU | 5328 | plasminogen activator, urokinase | The urokinse haplotype CGCCCC is a genetic risk fctor for higher mortality and more severe clinical outcome with infection-associated acute lung injury |
Human | MT2A | 4502 | metallothionein 2A | MT1 and MT2 deficient mice are susceptible to acute lung injury |
Human | MST1R | 4486 | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | Mst1r tyrosine kinase-domain deficient-mice have decreased survival times, alterations in cytokine and nitric oxide regulation, and an earlier onset of pulmonary pathology compared with control mice during acute lung injury |
Human | ITGAV | 3685 | integrin, alpha V | Increased transcripts of activators of TGFB1 (Itgav and Thbs1), and genes that are activated by TGFB1 (Spp1, Timp1, and Tnc) occurs during acute lung injury |
Human | INPP5D | 3635 | inositol polyphosphate-5-phosphatase, 145kDa | SHIP has a negative regulatory role in TLR2-induced neutrophil activation and in the development of related in vivo neutrophil-dependent inflammatory processes, such as acute lung injury in transgenic mice |
Human | IL8 | 3576 | interleukin 8 | Anti-IL-8:IL-8 complexes may be involved in the pathogenesis of lung inflammation in clinical acute lung injury |
Human | IL1B | 3553 | interleukin 1, beta | Soluble IL-1 beta bioactivity and autocrine IL-1 beta-dependent IL-6 up-regulation are critical initiators of fibroblast activation and proliferation and most likely play a role in the fibroproliferative response seen in human acute lung injury |
Human | IFNG | 3458 | interferon, gamma | IFN-gamma may be responsible for acute lung injury in the late phase of severe acute respiratory syndrome (SARS) pathology |
Human | ICAM1 | 3383 | intercellular adhesion molecule 1 | This review aims to further clarify the relationship between ICAM-1 and acute pancreatitis complicated by acute lung injury |
Human | TNC | 3371 | tenascin C | Tenascin C, a gene induced by TGF-beta, is markedly increased in mouse lung during acute lung injury |
Human | HMGB1 | 3146 | high mobility group box 1 | The results demonstrated that HMGB1 may play an important role as a modulator in apoptotic changes in polymorphonuclear granulocytes during lipopolysaccharide-induced acute lung injury |
Human | GZMB | 3002 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | Mice lacking funcitonal MST1R are suceptible to acute lung injury and have increased expression of granzymes in the lung, thymus and spleen |
Human | FGF7 | 2252 | fibroblast growth factor 7 | FGF7 improved survival during acute lung injury in mice |
Human | EDN1 | 1906 | endothelin 1 | In patients with acute lung injury/ARDS, ET-1 is produced mainly in the lung and is associated not only with pulmonary vasoconstriction but also the development of permeability oedema, leading to the impairment of oxygenation |
Human | ACE | 1636 | angiotensin I converting enzyme | Ace is a candidate gene for survival in acute lung injury in mice |