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Genes (18)
Species: human : 18 | |
Human | SMR3A | 26952 | submaxillary gland androgen regulated protein 3A | Results suggest that hSMR3A can act as a marker for erectile dysfunction associated with both diabetic and non-diabetic etiologies | Human | PDE5A | 8654 | phosphodiesterase 5A, cGMP-specific | no correlations of a novel polymorphism of the PDE5A promoter gene with the intermediate phenotype essential hypertension/erectile dysfunction | Human | TGFBR2 | 7048 | transforming growth factor, beta receptor II (70/80kDa) | Filtering bleb scarring is associated with an abundant expression of TGF-beta receptors in activated fibroblasts and the deposition of the fibrogenic ED-A fibronectin splice-variant | Human | ROCK1 | 6093 | Rho-associated, coiled-coil containing protein kinase 1 | Rho-kinase inhibition may be of value in treating age-related erectile dysfunction | Human | PON1 | 5444 | paraoxonase 1 | PON1 activity level was found to be significantly lower in erectile dysfunction patients than in the control group | Human | PLD2 | 5338 | phospholipase D2 | These results suggest that intact phosphorylation sites within the MARCKS ED are required for PLD activation and influence both membrane-cytoskeletal organization and cell viability | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Title:Genetic risk factors for erectile dysfunction and genetic determinants of drug response--on the way to improve drug safety?|Association:Not Found|Conclusion:Considering cardiovascular side effects under sildenafil treatment, it would be interesting to determine if genetic factors have an impact on the side effect profile of this drug. Title:ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction.|Association:Not Found|Conclusion:It appears that patients with elevated ACE serum concentrations, as associated with the D allele of the ACE I/D polymorphism, are less likely to respond to sildenafil. 'a' allele of ec-NOS gene intron 4 VNTR polymorphism associates with a better sildenafil response in patients with erectile dysfunction Title:Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population.|Association:Y|Conclusion:Therefore, our results suggest that Glu298Asp eNOS polymorphism plays a role as a genetic susceptibility factor for ED. In the Taiwanese population, the eNOS 894T allele carriers are at greater risk of ED, both in prevalence and severity, and this might be a factor of genetic susceptibility | Human | LPA | 4018 | lipoprotein, Lp(a) | The finding of high levels of LP(a) and MDA with low levels of nitric oxide in the peripheral and cavernous venous blood of diabetic men with erectile dysfunction (ED)correlates strongly with severity of ED as measured by PPDU | Human | LMNB1 | 4001 | lamin B1 | Impotence due to autonomic dysfunction | Human | HEXB | 3074 | hexosaminidase B (beta polypeptide) | | Human | GUCY1B3 | 2983 | guanylate cyclase 1, soluble, beta 3 | Although soluble guanylate cyclase(sGC) beta1-subunit expression was increased in mononuclear cells from patients with erectile dysfunction, the sGC activity was reduced | Human | GNB3 | 2784 | guanine nucleotide binding protein (G protein), beta polypeptide 3 | association of the G protein beta 3 subunit (GNB3) C825T polymorphism, a determinant of intracellular signal transduction, with the drug response to sildenafil in patients with erectile dysfunction Title:Genetic risk factors for erectile dysfunction and genetic determinants of drug response--on the way to improve drug safety?|Association:Not Found|Conclusion:Considering cardiovascular side effects under sildenafil treatment, it would be interesting to determine if genetic factors have an impact on the side effect profile of this drug. Our results failed to show a significant association of the GNB3 C825T polymorphisms with ED prevalence | Human | GH1 | 2688 | growth hormone 1 | plasma levels of ET-1, ACE activities are elevated and associated with reduction of GH, NO and cGMP levels in the systemic and cavernous blood of erectile dysfunction patients | Human | ACE | 1636 | angiotensin I converting enzyme | Title:ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction.|Association:Not Found|Conclusion:It appears that patients with elevated ACE serum concentrations, as associated with the D allele of the ACE I/D polymorphism, are less likely to respond to sildenafil. Title:Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population.|Association:Not Found|Conclusion:Therefore, our results suggest that Glu298Asp eNOS polymorphism plays a role as a genetic susceptibility factor for ED. The lack of carboxypeptidase activity in the DD genotype of the polymorphism of ACE might be the clue for erectile dysfunction pathogenesis Title:Genetic risk factors for erectile dysfunction and genetic determinants of drug response--on the way to improve drug safety?|Association:Not Found|Conclusion:Considering cardiovascular side effects under sildenafil treatment, it would be interesting to determine if genetic factors have an impact on the side effect profile of this drug. angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction | Human | COMT | 1312 | catechol-O-methyltransferase | This study suggest that a turnover of catecholamines, connected with polymorphism determining high activity of COMT enzyme, is connected with the risk of ED occurrence, particularly anorexia nervosa | Human | ENTPD1 | 953 | ectonucleoside triphosphate diphosphohydrolase 1 | Prolonged exposure to endogenous ATP related to decreased NTPDase1/CD39 activity leads to P2-purinoceptor desensitization in impotent men | Human | BMP2 | 650 | bone morphogenetic protein 2 | | Human | ABCD1 | 215 | ATP-binding cassette, sub-family D (ALD), member 1 | |
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