Human | BLOC1S3 | 388552 | biogenesis of lysosomal organelles complex-1, subunit 3 | Interstitial pulmonary fibrosis |
Human | HPS4 | 89781 | Hermansky-Pudlak syndrome 4 | Interstitial pulmonary fibrosis |
Human | HPS3 | 84343 | Hermansky-Pudlak syndrome 3 | Interstitial pulmonary fibrosis |
Human | DTNBP1 | 84062 | dystrobrevin binding protein 1 | Interstitial pulmonary fibrosis |
Human | HPS6 | 79803 | Hermansky-Pudlak syndrome 6 | Interstitial pulmonary fibrosis |
Human | NPHP3 | 27031 | nephronophthisis 3 (adolescent) | |
Human | HPS5 | 11234 | Hermansky-Pudlak syndrome 5 | Interstitial pulmonary fibrosis |
Human | VIM | 7431 | vimentin | The interstitial vimentin immunopositivity correlated with sclerotic/fibrotic lesions (interstitial fibrosis, tubular atrophies, vascular hyalinosis/fibrosis, chronicity index), and negatively with glomerular filtration rate |
Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF may play an important role in the development of interstitial fibrosis via mononuclear cell-induced cytokine production chronic kidney graft rejection |
Human | TNF | 7124 | tumor necrosis factor | SNPs of TNFalpha gene may not associate with SARS-CoV infection and may not affect interstitial lung fibrosis; however, the -1031CT/CC and -863 AC genotypes may be risk factors for femoral head necrosis |
Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | Cardiac expression of TIMP-1 and TIMP-2 is significantly increased in chronic pressure-overloaded human hearts compared with controls and is related to the degree of interstitial fibrosis |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Cardiac expression of TIMP-1 and TIMP-2 is significantly increased in chronic pressure-overloaded human hearts compared with controls and is related to the degree of interstitial fibrosis |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | The overall effects of TGF-beta1 in the kidney seem to be negative that increased expression of TGF-beta1 promotes interstitial fibrosis and vasculopathy associated with chronic allograft nephropathy The TGFbeta immunopositivity correlated with sclerotic/fibrotic lesions (interstitial fibrosis, tubular atrophies, vascular hyalinosis/fibrosis, chronicity index), and negatively with glomerular filtration rate Our study suggests a role of transforming growth factor beta-1 in interstitial fibrotic changes in renal AA and AL amyloidosis Our correlative study suggests a role of TGF-beta-1 in early interstitial fibrotic changes in acutely rejected renal allografts, and we hypothesize that endothelin-1 and myofibroblasts pathways may play an important role in this process |
Human | HNF1B | 6928 | HNF1 homeobox B | |
Human | PKHD1 | 5314 | polycystic kidney and hepatic disease 1 (autosomal recessive) | |
Human | NPHP1 | 4867 | nephronophthisis 1 (juvenile) | |
Human | NCAM1 | 4684 | neural cell adhesion molecule 1 | Renal NCAM-expressing interstitial cells can participate in the initial phase of interstitial fibrosis |
Human | HPS1 | 3257 | Hermansky-Pudlak syndrome 1 | Interstitial pulmonary fibrosis |
Human | GBE1 | 2632 | glucan (1,4-alpha-), branching enzyme 1 | Liver biopsy shows diffuse interstitial fibrosis |
Human | CX3CR1 | 1524 | chemokine (C-X3-C motif) receptor 1 | CX3CR1 may play an important role in the development of interstitial fibrosis via mononuclear cell-induced cytokine production chronic kidney graft rejection |
Human | CLCN5 | 1184 | chloride channel, voltage-sensitive 5 | |
Human | AQP3 | 360 | aquaporin 3 (Gill blood group) | reduction in the amounts of AQP-2 and AQP-3 expression, especially in lesions with substantial interstitial fibrosis and nephron loss, as compared with a healthy region of normal kidneys |
Human | AGT | 183 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | independent of systemic hemodynamic effects, cardiac ANG II may act locally in the heart, causing interstitial fibrosis in sham-myocardial infarction and accelerating deterioration of cardiac dysfunction and remodeling postmyocardial infarction |
Human | ACTG2 | 72 | actin, gamma 2, smooth muscle, enteric | It was suggested that peritubular alphaSMA-positive myofibroblastic cells, in collaboration with interstitial macrophages, contribute to the progression of interstitial fibrosis in diabetic nephropathy |