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Genes (70)
Species: human : 70 | |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Integrin alphavbeta6 is induced de novo in rodent and human liver fibrosis, where it is expressed on activated bile duct epithelia and (transitional) hepatocytes during fibrosis progression [integrin alphavbeta6] | Human | BBS12 | 166379 | Bardet-Biedl syndrome 12 | | Human | BBS5 | 129880 | Bardet-Biedl syndrome 5 | | Human | TTC8 | 123016 | tetratricopeptide repeat domain 8 | | Human | TMEM67 | 91147 | transmembrane protein 67 | | Human | ARL6 | 84100 | ADP-ribosylation factor-like 6 | | Human | CEP290 | 80184 | centrosomal protein 290kDa | | Human | BBS10 | 79738 | Bardet-Biedl syndrome 10 | | Human | FBRS | 64319 | fibrosin | In a rat model, ethanol can directly stimulate fibroblast proliferation and production of fibrogenic cytokines, particularly fibrosin, which appears to contribute to alcohol-induced hepatic fibrosis in vivo | Human | RETN | 56729 | resistin | In conclusion, this study shows a role for resistin as an intrahepatic cytokine exerting proinflammatory actions in HSCs, via a Ca2+/NF-kappaB-dependent pathway and suggests involvement of this adipokine in the pathophysiology of liver fibrosis | Human | PDGFC | 56034 | platelet derived growth factor C | PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis | Human | BBS7 | 55212 | Bardet-Biedl syndrome 7 | | Human | MKS1 | 54903 | Meckel syndrome, type 1 | | Human | BBS9 | 27241 | Bardet-Biedl syndrome 9 | | Human | NPHP3 | 27031 | nephronophthisis 3 (adolescent) | Title:Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis.|Association:Not Found|Conclusion:Interventional studies in the pcy mouse have shown beneficial effects by modification of protein intake and administration of methylprednisolone, suggesting therapeutic strategies for treating individuals with NPHP3. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis Hepatic fibrosis ({608002.0002}) | Human | TRIM32 | 22954 | tripartite motif containing 32 | | Human | ZNF267 | 10308 | zinc finger protein 267 | The binding site for NF-Y is critical for ZNF267 gene regulation and, herewith, the activation of this transcriptional factor plays an important role in the activation process of hepatic stellate cells and in liver fibrosis | Human | SOCS1 | 8651 | suppressor of cytokine signaling 1 | Severity of liver fibrosis is strongly correlated with SOCS1 gene methylation | Human | MKKS | 8195 | McKusick-Kaufman syndrome | | Human | ADAM12 | 8038 | ADAM metallopeptidase domain 12 | p70 s6 kinase is involved in upregulation of ADAM12 gene expression associated with hepatic stellate cell activation during liver injury contributing to liver fibrosis and liver tumor progression | Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF appeared more common as compared to CD 34 in early liver fibrosis | Human | TNF | 7124 | tumor necrosis factor | IL-10 or TNF-alpha expression variation is not associated with alterations in HCV clearance or ALT levels, but TNF-alpha polymorphisms may be associated with hepatic fibrosis Carriage of the TNF308.2 allele correlates with disease severity and hepatic fibrosis, which may contribute to a higher risk for HCC | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | elevated TIMP-1 levels may reflect the degree of hepatic fibrosis and development of portal hypertension with biliary atresia; TIMP-1 may play a role in the pathophysiology of post-Kasai biliary atresia | Human | TGFBR2 | 7048 | transforming growth factor, beta receptor II (70/80kDa) | blockade of TGF-beta after intramuscular transfer of the soluble type II TGF-beta receptor gene suppressed hepatic fibrosis | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGFbeta1 activity during liver fibrosis is specifically antagonized by pleiotrophin TGF-beta(1) expression was significantly correlated with both hepatic fibrosis and the percentage of portal tracts showing histological abnormalities associated with cystic fibrosis liver disease TGF beta 1 polymorphisms (C allele at - 509C>T, T allele at codon10 T>C) contribute to progression of hepatic fibrosis in Chinese with hepatitis B virus infection transcription upregulated directly by Hepatitis C virus core protein in parenchymal cells and suggests a new paradigm for exacerbation of liver fibrosis by HCV infection Chronic inflammation associated with hepatitis C virus infection shifts hepatocytic TGF-beta signaling from tumor-suppression to fibrogenesis, accelerating liver fibrosis and increasing risk for hepatocarcinoma Title:Association of polymorphisms of the transforming growth factor-beta1 gene with the rate of progression of HCV-induced liver fibrosis.|Association:Not Found|Conclusion:Our results indicate that the heterozygous ArgPro of codon 25 predicts significantly faster fibrotic progression of chronic hepatitis C than the homozygous (25)ArgArg genotype. The homozygous LeuLeu genotype of codon 10 showed a slow progression of fibrosis. Association of polymorphisms of the transforming growth factor-beta1 gene with the rate of progression of HCV-induced liver fibrosis The combination of high AT and TGF-beta1 producing polymorphisms is associated with advanced hepatic fibrosis in obese patients with non-alcoholic fatty liver disease |
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