Genes (140)
Species: human : 139 mouse : 1 | |
Mouse | NCOA4 | 8031 | nuclear receptor coactivator 4 | PP1 prevented the growth of two human papillary thyroid carcinoma cell lines that carry spontaneous RET/PTC1 rearrangements and blocked anchorage-independent growth and tumorigenicity in nude mice of NIH3T3 fibroblasts expressing the RET/PTC3 oncogene. | Human | MIR146A | 406938 | microRNA 146a | a pre-miR-146a single nucleotide polymorphism decreases mature miR expression and predisposes to papillary thyroid carcinoma | Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Ret/PTC-1 activation may dampen immunogenic responses in the thyroid, which could possibly facilitate papillary thyroid carcinoma development.[ret/PTC-1] | Human | SLC5A8 | 160728 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | Methylation-specific PCR analyses showed that SLC5A8 was methylated in 90% of PTC-cf. and in about 20% of other papillary thyroid carcinomas. Silencing of the Tumor Suppressor Gene SLC5A8 Is Associated with BRAF Mutations in Classical Papillary Thyroid Carcinomas. SLC5A8 expression was selectively down-regulated (40-fold) in papillary thyroid carcinomas of classical form (PTC-cf.). | Human | GADD45GIP1 | 90480 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | Expression of CRIF1 is barely detectable in adrenal adenoma and papillary thyroid cancer and much lower than in adjacent normal tissue. | Human | KISS1R | 84634 | KISS1 receptor | Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. | Human | NAA15 | 80155 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | NATH, a novel gene overexpressed in papillary thyroid carcinomas levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures | Human | C11orf30 | 56946 | chromosome 11 open reading frame 30 | Data examine possible allelic imbalance in papillary thyroid cancer at EMSY, CAPN5, and PAK1, as candidate genes within 11q13.5-q14 region using a single nucleotide polymorphism-based analysis | Human | ERRFI1 | 54206 | ERBB receptor feedback inhibitor 1 | High mitogen inducible gene 6 expression in papillary thyroid cancer is associated with greater survival and MIG-6 expression correlates directly with EGFR expression | Human | WWOX | 51741 | WW domain containing oxidoreductase | WWOX underexpression is an important step that might increase the vulnerability to the carcinogenesis process in papillary thyroid carcinomas | Human | TCO | 50975 | Thyroid carcinoma, nonmedullary, with cell oxyphilia | At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family. | Human | ERC1 | 23085 | ELKS/RAB6-interacting/CAST family member 1 | Analysis of the gene structure of four isoforms (ELKS beta, ELKS gamma, ELKS delta, and ELKS epsilon) in a case of papillary thyroid carcinoma reveal that the isoforms are produced by alternative splicing | Human | PRSS23 | 11098 | protease, serine, 23 | It included the following 19 genes: DPP4, GJB3, ST14, SERPINA1, LRP4, MET, EVA1, SPUVE, LGALS3, HBB, MKRN2, MRC2, IGSF1, KIAA0830, RXRG, P4HA2, CDH3, IL13RA1, and MTMR4, and correctly discriminated 17 of 18 additional PTC/normal thyroid samples and all 16 samples published in a previous microarray study. | Human | FRS2 | 10818 | fibroblast growth factor receptor substrate 2 | These experiments demonstrate that FRS2 couples both ligand-regulated and oncogenic forms of RET, with the MAP kinase signaling cascade as part of the response of RET under normal biological conditions and pathological conditions, such as MEN 2 and papillary thyroid carcinomas. | Human | TFG | 10342 | TRK-fused gene | TRK-fused gene (TFG) was originally identified in humans as the N-terminus of an oncogenic fusion protein TRK-T3, associated with papillary thyroid carcinoma. The TFG sequence is fused to the 3; end of NTRK1, generating the TRK-T3 fusion transcript found in papillary thyroid carcinoma. TFG was discovered as a fusion partner of NTRK1 in human papillary thyroid carcinoma. | Human | TOB1 | 10140 | transducer of ERBB2, 1 | Phosphorylation and inactivation of Tob contributes to the progression of papillary carcinoma of the thyroid. | Human | CXCL14 | 9547 | chemokine (C-X-C motif) ligand 14 | CST6, CXCL14, DHRS3, and SPP1 are regulated by BRAF signaling and may play a role in papillary thyroid carcinoma pathogenesis | Human | DHRS3 | 9249 | dehydrogenase/reductase (SDR family) member 3 | CST6, CXCL14, DHRS3, and SPP1 are regulated by BRAF signaling and may play a role in papillary thyroid carcinoma pathogenesis | Human | TRIM24 | 8805 | tripartite motif containing 24 | The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. | Human | TP63 | 8626 | tumor protein p63 | Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto;s thyroiditis: A stem cell hypothesis of papillary carcinoma oncogenesis. Expression of p63 in papillary thyroid carcinoma and in Hashimoto;s thyroiditis: a pathobiologic link? Given the debated association of papillary thyroid carcinoma with Hashimoto;s thyroiditis, it is possible that p63 expression may be a potential pathobiologic link between the two disorders. Based on the results of this study, we conclude that p63 is commonly expressed in papillary thyroid carcinoma and in Hashimoto;s thyroiditis. | Human | PARG | 8505 | poly (ADP-ribose) glycohydrolase | Since chromosomal rearrangements in thyroid papillary carcinoma and loss of heterozygosity in glioblastoma are frequently observed in this region, genetic alteration of PARG could be implicated in these diseases. | Human | CDC7 | 8317 | cell division cycle 7 | The aggressive, poorly differentiated PtC group was specifically characterized by marked upregulation of several genes related to cell proliferation such as cell division cycle 2 (CDC2), CDC7, kinesin-like 5, ubiquitin conjugating enzyme E2C, and topoisomerase IIalpha, and by upregulation of genes encoding extracellular matrix proteins such as seprase, extracellular matrix protein 1, and several collagens. | Human | NAA10 | 8260 | N(alpha)-acetyltransferase 10, NatA catalytic subunit | levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures | Human | RASSF7 | 8045 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | "rare" alleles of HRas1 minisatellite are associated with increased risk of papillary thyroid cancer formation in children and adolescents after Chernobyl accident | Human | NCOA4 | 8031 | nuclear receptor coactivator 4 | Click here to display 20 evidence detail records. |
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