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Genes (43)
Species: human : 43 | |
Human | RXFP2 | 122042 | relaxin/insulin-like family peptide receptor 2 | In the anaplastic thyroid carcinoma cell line 8505C, the regulation of both INSL-3 and LGR8 by estrogen may be the first indication of a novel hormonally responsive, auto-/paracrine INSL-3 LGR8 ligand receptor system active in human thyroid carcinoma cells. Treatment of the human anaplastic thyroid carcinoma cell line 8505C with diethylstilbestrol (DES) caused a significant dose-dependent transcriptional down-regulation of INSL-3 and a marked up-regulation of LGR8. | Human | ITCH | 83737 | itchy E3 ubiquitin protein ligase | ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization | Human | DUSP26 | 78986 | dual specificity phosphatase 26 (putative) | DUSP26 effectively dephosphorylates p38 and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer | Human | UBE2C | 11065 | ubiquitin-conjugating enzyme E2C | UbcH10 overexpression is involved in thyroid cell proliferation and may represent a marker of thyroid anaplastic carcinomas Cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma | Human | KIAA0101 | 9768 | KIAA0101 | Overexpression of KIAA0101 is associated with anaplastic thyroid carcinoma | Human | ABCG2 | 9429 | ATP-binding cassette, sub-family G (WHITE), member 2 | The expression of ABCG2 may explain in part the ineffectiveness of doxorubicin as a single modality treatment for anaplastic thyroid cancer or for treatment of metastatic follicular thyroid cancer | Human | AURKB | 9212 | aurora kinase B | Immunohistochemical analysis of archive samples showed a high expression of Aurora B in anaplastic thyroid carcinomas; conversely, Aurora B expression was not detectable in normal thyroid tissue. Real-time PCR analysis confirmed a strong expression of Aurora B in anaplastic thyroid carcinomas. Block of Aurora B expression induced by RNA interference or by using an inhibitor of Aurora kinase activity significantly reduced the growth of thyroid anaplastic carcinoma cells Anaplastic carcinoma of the thyroid--will aurora B light a path for treatment? | Human | TP63 | 8626 | tumor protein p63 | P63 expression in papillary and anaplastic carcinomas of the thyroid gland: lack of an oncogenetic role in tumorigenesis and progression. | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | findings suggest that a subset of anaplastic thyroid carcinoma cells expresses functional CXCR4, which may be important in tumor cell migration and local tumor invasion CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells. CXCR4 targeting is a novel potential strategy in the treatment of human anaplastic thyroid cancer | Human | PAX8 | 7849 | paired box 8 | lack of the PAX8/PPAR gamma rearrangement in the anaplastic thyroid carcinoma group suggests that the tumorigenic pathway in these tumors is likely to be independent of this fusion | Human | TPO | 7173 | thyroid peroxidase | Reexpression of thyroid peroxidase in a derivative of an undifferentiated thyroid carcinoma cell line by introduction of wild-type p53. The main conclusions of our study are that 1) the TSH-R gene is expressed in some MTC, which supports, at molecular level, the hypothesis of the existence of mixed follicular-medullary thyroid tumors; and 2) the expression of TSH-R, Tg, and TPO in undifferentiated thyroid cancer is lost. Histone deacetylase inhibitors restore radioiodide uptake and retention in poorly differentiated and anaplastic thyroid cancer cells by expression of the sodium/iodide symporter thyroperoxidase and thyroglobulin. Iodide uptake in human anaplastic thyroid carcinoma cells after transfer of the human thyroid peroxidase gene. | Human | TP53 | 7157 | tumor protein p53 | Antisense ODN to p53 impairs secretion of VEGF in the undifferentiated thyroid cancer cell line FTC-133 | Human | NKX2-1 | 7080 | | Anaplastic thyroid carcinoma tissue express TTF1 mRNA abundantly However, most poorly differentiated and anaplastic thyroid carcinomas have lost the ability to express the TG gene expression accompanied by loss of transcription factors [thyroid transcription factor-1 (TTF-1), TTF-2, or Pax-8] interacting with the TG promoter. Messenger RNA of a thyroid specific transcription factor, TTF-1, known to regulate the normal function of thyrocytes, was found in the toxic goitre but not in the anaplastic thyroid carcinoma cell lines. | Human | TGFB3 | 7043 | transforming growth factor, beta 3 | The role of TGF-beta1 and -beta3 in generating a high TIFP was investigated in xenografted experimental anaplastic thyroid carcinoma (ATC) derived from the human ATC cell line | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | The role of TGF-beta1 and -beta3 in generating a high TIFP was investigated in xenografted experimental anaplastic thyroid carcinoma (ATC) derived from the human ATC cell line | Human | TG | 7038 | thyroglobulin | expression level of thyroglobulin mRNA in the anaplastic thyroid carcinoma tissue and cell lines was <10(2) times higher than that in the differentiated thyroid carcinomas | Human | TERT | 7015 | telomerase reverse transcriptase | TGF-beta1 exerts opposing effects on telomerase activity in anaplastic thyroid carcinoma cell lines loss of miR-138 expression may partially contribute to the gain of telomerase reverse transcriptase protein expression in anaplastic thyroid carcinoma | Human | HNF1B | 6928 | HNF1 homeobox B | Three anaplastic papillary thyroid cancer cell lines expressed HNF-1beta | Human | HNF1A | 6927 | HNF1 homeobox A | HNF-1alpha mRNA was expressed in four of the six anaplastic papillary thyroid cancer cell lines | Human | SLC5A5 | 6528 | solute carrier family 5 (sodium/iodide cotransporter), member 5 | NIS gene expression has beneficial effects in human anaplastic thyroid carcinoma cells | Human | RET | 5979 | ret proto-oncogene | study demonstrated RET amplification in all 3 cases of radiation-associated thyroid cancers(papillary thyroid cancer (PTC) & anaplastic thyroid cancer(ATC) but not in sporadic well-differentiated PTC; RET amplification was observed in all 6 cases of ATCs | Human | PTH1R | 5745 | parathyroid hormone 1 receptor | Manumycin inhibits cell proliferation and decreases PTHrP levels in anaplastic thyroid cancer cells in vitro and in vivo and decreases the PTHrP level in the nucleus | Human | PTEN | 5728 | phosphatase and tensin homolog | PTEN silencing in anaplastic thyroid cancer is a result of a wide variety of epigenetic and/or structural silencing mechanisms rather than a consequence of structural biallelic inactivation of the classical type | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | lack of the PAX8/PPAR gamma rearrangement in the anaplastic thyroid carcinoma group suggests that the tumorigenic pathway in these tumors is likely to be independent of this fusion | Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Mutant PIK3CA is likely to function as an oncogene in anaplastic thyroid cancer and less frequently well-differentiated thyroid carcinomas |
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