Mouse | DLEC1 | 9940 | deleted in lung and esophageal cancer 1 | Click here to display 5 evidence detail records. |
Mouse | FGR | 2268 | feline Gardner-Rasheed sarcoma viral oncogene homolog | Although no c-fgr expression was detected in EBV-positive or -negative epithelial cell lines, the 3.0-kb c-fgr mRNA was detected at low levels in mRNA obtained from NPC biopsy specimens. However, NPC tissue, after passage in nude mice (which eliminates infiltrating lymphoid and myeloid cells) did not contain the 3.0-kb c-fgr mRNA. |
Human | LOC100507436 | 100507436 | | Title:[Polymorphism of short tandem repeat of exon 5 of MHC class-I chain related gene A and association with nasopharyngeal carcinoma in a southern Chinese population]|Association:Not Found|Conclusion:MICA-STR polymorphism is associated with NPC, and MICA*A9 is a genetic susceptibility marker of male individuals for NPC in a southern Chinese population. Title:[Studies on the polymorphism of MICA gene in four Chinese populations]|Association:Not Found|Conclusion:Alleles of MICA gene exon 5 are conservative in all populations studied so far. The results suggest that genetically BMT might be an independent ethnic population. The results provide strong supporting evidence suggesting that MICA*A9 may be a genetic risk factor for nasopharyngeal carcinoma in male individuals in the southern Chinese Han population |
Human | LOC344967 | 344967 | acyl-CoA thioesterase 7 pseudogene | results provide evidence that the -32A variant of LOC344967 is a functional sequence change and may be related to nasopharyngeal carcinoma susceptibility in the families studied |
Human | H19 | 283120 | H19, imprinted maternally expressed transcript (non-protein coding) | Regulation of the H19 imprinting gene expression in human nasopharyngeal carcinoma by methylation |
Human | NPC1 | 257641 | Niemann-Pick disease, type C1 | |
Human | COX7B2 | 170712 | cytochrome c oxidase subunit VIIb2 | codon 26 of COX7B2 gene might be evolutionarily conserved and the rare variation His26Gln may be associated with a high risk of nasopharyngeal carcinoma |
Human | OSCP1 | 127700 | organic solute carrier partner 1 | Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE1 nasopharyngeal carcinoma cell line. [Expression of a new cloned nitroreductase gene NOR1 and purification of expressed product] BACKGROUND _amp_ OBJECTIVE: NOR(1)is a good candidate of tumor suppressor/susceptibility gene associated with nasopharyngeal carcinoma. |
Human | C20orf114 | 92747 | | LPLUNC1 is found to be down-expressed in 33 of 48 nasopharyngeal carcinoma biopsies |
Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | Click here to display 8 evidence detail records. |
Human | TUBA1C | 84790 | tubulin, alpha 1c | When patients and controls were stratified according to their age, IgG autoantibodies to tubulin were found specifically associated with the young age onset of the nasopharyngeal carcinoma (age under 25 years). Autoantibodies to tubulin are specifically associated with the young age onset of the nasopharyngeal carcinoma. Bioassay-guided fractionation of the extracts of Zieridium pseudobtusifolium and Acronychia porteri led to the isolation of 5,3-dihydroxy-3,6,7,8,4-pentamethoxyflavone [1], which showed activity against (KB) human nasopharyngeal carcinoma cells (IC50 0.04 micrograms/ml) and inhibited tubulin assembly into microtubules (IC50 12 microM). |
Human | RASSF5 | 83593 | Ras association (RalGDS/AF-6) domain family member 5 | In this study, we aimed to investigate the expression and methylation status of RASSF4/AD037 and NORE1 in nasopharyngeal carcinoma (NPC) in which RASSF1A is frequently inactivated by promoter hypermethylation. |
Human | CENPH | 64946 | centromere protein H | CENP-H has a role in preventing progression of nasopharyngeal carcinoma |
Human | HPSE2 | 60495 | heparanase 2 | Heparanase expression is inversely correlated with survival of nasopharyngeal carcinoma (NPC) patients, indicating heparanase is a reliable prognostic factor, and further supports that heparanase is a valid target for the development of anti-cancer drugs |
Human | PCDH10 | 57575 | protocadherin 10 | It resides at 4q28.3--a region with hemizygous deletion detected by array-CGH in NPC cell lines; however, PCDH10 itself is not located within the deletion. As tumor-specific promoter methylation is a marker for tumor suppressor genes (TSG), we searched for epigenetically inactivated TSGs using methylation-subtraction combined with pharmacologic demethylation, and identified the PCDH10 CpG island as a methylated sequence in nasopharyngeal carcinoma (NPC). |
Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | downregulation of CHFR is a common event in nasopharyngeal carcinoma cells which may be due to hypermethylation of the gene promoter region Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation. |
Human | TMEM8B | 51754 | transmembrane protein 8B | Click here to display 7 evidence detail records. |
Human | MED15 | 51586 | mediator complex subunit 15 | TIG1 gene Silencing by promoter hypermethylation is associated with nasopharyngeal carcinoma |
Human | ZMYND10 | 51364 | zinc finger, MYND-type containing 10 | Click here to display 5 evidence detail records. |
Human | PLUNC | 51297 | | Click here to display 5 evidence detail records. |
Human | UBAP1 | 51271 | ubiquitin associated protein 1 | Decreased expression of UBAP1 protein is a possible point of dysfunction along the pathogenesis pathway for nasopharyngeal carcinoma that may contribute to malignant transformation |
Human | LOH3CR2A | 29931 | | Click here to display 5 evidence detail records. |
Human | BRD7 | 29117 | bromodomain containing 7 | BRD7 is a novel bromodomain gene and it is downexpressed in nasopharyngeal carcinoma (NPC) biopsies and cell lines; its function is poorly understood. BRD7 promoter demethylation is a prerequisite for high level induction of BRD7 gene expression in human nasopharyngeal carcinoma cells |
Human | NAT6 | 24142 | N-acetyltransferase 6 (GCN5-related) | newly identified polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase and the proline-rich domains; analysis suggests no likely association between nasopharyngeal cancer and the FUS2 gene polymorphism |
Human | CADM1 | 23705 | cell adhesion molecule 1 | Epigenetic inactivation of TSLC1 gene is associated with nasopharyngeal carcinoma Epigenetic inactivation of TSLC1 gene in nasopharyngeal carcinoma. Fine mapping of the 11q22-23 tumor suppressive region and involvement of TSLC1 in nasopharyngeal carcinoma. |