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Details
Link-It Detail - Disease - Pick Disease of the Brain
Debug Stats
  • ### Total Build Time: 41 ms 32.441 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 348 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 690 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 544 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 2.796 KB
  • CONCEPT_RELATIONSHIPS gt=22 ms Completed: 22 ms rowSize= 13.660 KB
  • CONCEPT_GENES gt=8 ms Completed: 8 ms rowSize= 13.062 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.159 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Pick Disease of the Brain C0236642
Definition (1)
A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Dementia C0497327
Ancestral Roots
RootRoot Plus OneDepthParent
img Mental Disorders C0004936img Delirium, Dementia, Amnestic, Cognitive Disorders C00292274img Dementia C0497327
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Dementia C0497327
Relationships (44)

Relation Types:
diso_​to_​anat : 6
diso_​to_​chem : 1
diso_​to_​diso : 36
diso_​to_​phen : 1


Relationships:
none : 10
classifies : 2
entry_​version_​of : 1
inheritance_​type_​of : 1
is_​associated_​anatomic_​site_​of : 2
manifestation_​of : 25
mapped_​to : 2
used_​for : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN26img genetic aspects C0017399
DISO_to_DISO22img Alzheimer Disease C0002395
DISO_to_CHEM19img tau Proteins C0085401
DISO_to_DISO19img Dementia C0497327
DISO_to_ANAT18img Brain C0006104
DISO_to_DISO11img Complication Aspects C1171258
DISO_to_ANAT8img Bodies, Inclusion C0007637
DISO_to_ANAT8img Brain C0006104
DISO_to_ANAT8img Frontal Lobe C0016733
DISO_to_DISO7img Complication Aspects C1171258
DISO_to_ANATis_associated_anatomic_site_ofimg Central Nervous System C0927232
DISO_to_ANATis_associated_anatomic_site_ofimg Nervous System C0027763
DISO_to_DISOmanifestation_ofimg Argyrophilic hyperphosphorylated tau-positive inclusions (Pick bodies) C1868314
DISO_to_DISOmanifestation_ofimg Atrophy may be more severe in the left hemisphere C1868313
DISO_to_DISOmanifestation_ofimg Blunted affect C0233469
DISO_to_DISOmanifestation_ofimg Caused by mutation in the microtubule-associated tau protein gene (MAPT, 157140.0011) C1868319
DISO_to_DISOmanifestation_ofimg Caused by mutation in the presenilin-1 gene (PSEN1, 104311.0027) C1868320
DISO_to_DISOmanifestation_ofimg Change in personality C0240735
DISO_to_DISOmanifestation_ofimg ECHOLALIA C0013528
DISO_to_DISOmanifestation_ofimg Frontotemporal Dementia C0338451
DISO_to_DISOmanifestation_ofimg Frontotemporal lobar atrophy with 'knife-edge' distinction C1868312
DISO_to_DISOmanifestation_ofimg Gliosis C0017639
DISO_to_DISOmanifestation_ofimg Hyperoralia C1838320
DISO_to_DISOmanifestation_ofimg Hyperphagia C0020505
DISO_to_DISOmanifestation_ofimg Inappropriate laughter C0424304
Genes (11)

Species:
human : 11
SpeciesGeneGeneIdGene NameEvidence
HumanSTH246744saitohin
img GENERIF, Score=1000, Pubmed Id: 16186110, UMLKSK CUI: C0236642
HumanPCSK1N27344proprotein convertase subtilisin/kexin type 1 inhibitor
img GENERIF, Score=1000, Pubmed Id: 12914799, UMLKSK CUI: C0236642
HumanPRDX310935peroxiredoxin 3
img GENERIF, Score=1000, Pubmed Id: 12650976, UMLKSK CUI: C0236642
HumanPRDX69588peroxiredoxin 6
img GENERIF, Score=1000, Pubmed Id: 12650976, UMLKSK CUI: C0236642
HumanPRDX27001peroxiredoxin 2
img GENERIF, Score=1000, Pubmed Id: 12650976, UMLKSK CUI: C0236642
HumanPSEN15663presenilin 1
img GENERIF, Score=1000, Pubmed Id: 15622541, UMLKSK CUI: C0236642
HumanPIN15300peptidylprolyl cis/trans isomerase, NIMA-interacting 1
img GENERIF, Score=1000, Pubmed Id: 14572447, UMLKSK CUI: C0236642
HumanPRDX15052peroxiredoxin 1
img GENERIF, Score=1000, Pubmed Id: 12650976, UMLKSK CUI: C0236642
HumanMSI14440musashi RNA-binding protein 1
img GENERIF, Score=1000, Pubmed Id: 16106215, UMLKSK CUI: C0236642
HumanMAPT4137microtubule-associated protein tau
img GENERIF, Score=1000, Pubmed Id: 12112079, UMLKSK CUI: C0236642
img GENERIF, Score=1000, Pubmed Id: 12368187, UMLKSK CUI: C0236642
HumanADORA1134adenosine A1 receptor
img GENERIF, Score=1000, Pubmed Id: 18052973, UMLKSK CUI: C0236642
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0236642Pick Disease of the Brain0self