human : 65
|Human||RPRM||56475||reprimo, TP53 dependent G2 arrest mediator candidate|
Promoter methylation of Reprimo was found in 79% of gastric cancers, 62% of gallbladder cancers, 57% of lymphomas, 56% of colorectal cancers, 40% of esophageal adenocarcinomas, 37% of breast cancers and 31% of leukemias.
|Human||SH3GLB1||51100||SH3-domain GRB2-like endophilin B1|
Bif-1 expression might play a role in tumorigenesis in both urinary bladder (UB) and gallbladder (GB) cancer
High expression of heparanase, combined with NF-kappaB p65, may contribute to the highly invasive and metastatic behavior of gallbladder carcinoma
|Human||KEAP1||9817||kelch-like ECH-associated protein 1|
Aberrant Nrf2 activation provoked by Keap1 alteration is one of the molecular mechanisms for chemotherapeutic resistance in gallbladder cancer
Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas, we investigated NMT activity and protein expression of NMT1 and NMT2 in human brain tumors and documented elevated NMT activity and higher protein expressions.
Results suggest the importance of tumor-infiltrating CD83(+) dendritic cells as a useful prognostic factor for patients with gallbladder carcinoma
Prognostic significance of CD83 positive, mature dendritic cells in the gallbladder carcinoma.
|Human||EBAG9||9166||estrogen receptor binding site associated, antigen, 9|
High expression of RCAS1 significantly correlated with tumour progression and predicted poor outcome in gallbladder cancer.
Immunohistochemically, RCAS1 was expressed in a high percentage of biliary adenocarcinomas (85.9% of intrahepatic cholangiocarcinomas, 96.4% of extrahepatic cholangiocarcinomas and gallbladder carcinomas).
We sought to determine RCAS1 involvement in the origin and progression of gallbladder cancer, and also implications of RCAS1 for patient survival.
RCAS1 as a tumour progression marker: an independent negative prognostic factor in gallbladder cancer.
The expression rates of P62 and bFGF were all correlated with MVD in gallbladder carcinoma tissues(P<0.05 and P<0.01), respectively.
AIM: To detect the expressions of P62 and bFGF in human gallbladder carcinoma tissues and microvessel density(MVD) inside tumor, explore their correlation with each other, and their relationship with tumor;s clinical pathological properties.
CONCLUSION: Expressions of P62 and bFGF were closely associated with angiogenesis in gallbladder carcinoma tissues, which may play a pivotal role in genesis and progression in gallbladder carcinoma.
Expressions of P62 and bFGF may be helpful for diagnosis and therapy of gallbladder carcinoma.
METHODS: The expressions of P62 and bFGF in 41 cases of human gallbladder carcinoma tissues and 22 cases of chronic cholecystitis tissues were detected by SP immunohistochemical staining.
[Expression of P62 in gallbladder carcinoma tissues and its correlation with angiogenesis]
RESULTS: The positive rates of P62 and bFGF in 41 cases of gallbladder carcinoma tissues (63.4% and 75.6%, respectively) were significantly higher than those in 22 cases of chronic cholecystitis tissues(P<0.01).
|Human||VEGFC||7424||vascular endothelial growth factor C|
Expresssed in gallbladder cancer and is related to lymph node metastasis
|Human||VEGFA||7422||vascular endothelial growth factor A|
Results suggest that the p53-VEGF pathway can regulate tumor angiogenesis in human gallbladder carcinoma
|Human||TP53||7157||tumor protein p53|
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of gallbladder cancer among Japanese women and men, respectively
p53 mutations and microsatellite instability differ in patients with gallbladder carcinoma between two distinct high-incidence areas
p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer
Overexpression of p53 was associated with poor survival in gallbladder carcinomas
TP53 abnormalities are early and frequent events in the pathogenesis of gallbladder carcinoma, starting from chronic cholecystitis
|Human||TOP2A||7153||topoisomerase (DNA) II alpha 170kDa|
Somatostatin could induce cell cycle arrest in S phase and upregulate Topo IIalpha expression in gallbladder cancer cells
topoisomerase IIalpha might be an effective chemotherapeutic target in advanced gallbladder carcinoma
|Human||TNF||7124||tumor necrosis factor|
TNFA-308G/A polymorphism is associated with gallbladder cancer
TNF is involved in the pathogenesis of gallbladder carcinoma induced by gallstones
|Human||TIMP2||7077||TIMP metallopeptidase inhibitor 2|
correlation between expression of MMP-2, TIMP-2 protein and the ratio of MMP-2/TIMP-2 and clinical-pathological parameters of patients with gallbladder carcinoma
CONCLUSION: TIMP-2 and MMP-2/TIMP-2 ratio could reflect more accurately biological characteristic of gallbladder carcinoma and MMP-2/TIMP-2 ratio might be a new significant marker in early diagnosis, in the judgment of invasion or metastasis and the estimate of prognosis in patients with gallbladder carcinomas.
|Human||TGFB1||7040||transforming growth factor, beta 1|
Transforming growth factor beta overexpression is associated with advanced stage gallbladder cancer
the combination of the GG genotype of EGF and the CT genotype of TGFB1 demonstrated synergistic increase in risk of gallbladder cancer
|Human||TFF1||7031||trefoil factor 1|
trefoil factor family protein 1(TFF1)is expressed in inflamed non-neoplastic gallbladder epithelium and in low stage and low grade gallbladder carcinomas
Expression of pS2 (an estrogen-induced gene isolated from breast carcinoma MCF7 cells) and of the human spasmolytic peptide (hSP) gene was analyzed in 21 human biliary tract and gallbladder carcinomas and 16 non-neoplastic gallbladders at the protein level (immunochemistry) and, in a series of these cases, at the RNA level (Northern blots).
|Human||TERC||7012||telomerase RNA component|
In analysing main types of the human cancers, the positive frequency of hTR and hTRT were 94% (15/16) and 88% (14/16) for the breast cancer, 85% (17/20) and 90% (18/20) for the colon cancer, 80% (8/10) and 80% (8/10) for the gallbladder cancer, 75% (6/8) and 75% (6/8) for the lung cancer, 75% (6/8) and 75% (6/8) for the stomach cancer, and 83% (5/6) and 83% (5/6) for the esophagus cancer, respectively.
|Human||SKP2||6502||S-phase kinase-associated protein 2, E3 ubiquitin protein ligase|
Skp2 overexpression is highly representative of biological aggressiveness of gallbladder carcinoma and is independently associated with poor overall survival
|Human||S100A4||6275||S100 calcium binding protein A4|
Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expression.
Prognostic significance of S100A4 expression in gallbladder cancer.
In order to clarify the significance of the expression of S100A4 as a prognostic factor in gallbladder cancer, S100A4 expression in resected gallbladder cancers were examined using an immunohistochemical staining technique.
These results indicate that positive staining for S100A4 is useful in assessing the prognosis of patients with gallbladder cancer as well as TNM factors.
Mutation of p16 and Rb genes might be correlated with progression of gallbladder carcinoma
|Human||PTGS2||5743||prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)|
Augmented tumor neovascularization induced by VEGF may be one of the several effects of COX-2 responsible for poor prognosis of human gallbladder carcinoma
In advanced gallbladder carcinoma, enhanced expression of cyclooxygenase-2 is observed in the adjacent stroma
|Human||PTGER4||5734||prostaglandin E receptor 4 (subtype EP4)|
Increased PGE(2) synthesis in the adjacent stroma and its biological effect via EP(4) on the carcinoma cells may contribute to tumor growth and progression of gallbladder carcinoma
Overexpression of PML was associated with poor survival in gallbladder carcinomas
|Human||ABCB1||5243||ATP-binding cassette, sub-family B (MDR/TAP), member 1|
MDR1 gene expression in gallbladder carcinoma is correlated with some biological characteristics, takes part in the carcinogenesis of gallbladder tissues, and acts as a valuable biomarker of prognosis
|Human||OGG1||4968||8-oxoguanine DNA glycosylase|
These results suggest that hOGG1 Ser326Cys polymorphism is associated with gallbladder cancer risk