GATACA

Credits

Hide Credits

Data

Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

ToppGene Links (Credits)

Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
//
// Permission is hereby granted, free of charge, to any person obtaining
// a copy of this software and associated documentation files (the
// "Software"), to deal in the Software without restriction, including
// without limitation the rights to use, copy, modify, merge, publish,
// distribute, sublicense, and/or sell copies of the Software, and to
// permit persons to whom the Software is furnished to do so, subject to
// the following conditions:
//
// The above copyright notice and this permission notice shall be
// included in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
// EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
// MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
// NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
// LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
// OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
// WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
//
// For details, see the script.aculo.us web site: http://script.aculo.us/

Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - EXCITABILITY

Debug Stats

### Total Build Time: 34 ms 34.460 KB
CONCEPT_NAME gt=14 ms Completed: 14 ms rowSize= 322 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
Skipping details on: CONCEPT_DEFINITION gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
CONCEPT_RELATIONSHIPS gt=2 ms Completed: 2 ms rowSize= 1.099 KB
CONCEPT_GENES gt=15 ms Completed: 15 ms rowSize= 31.830 KB
CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.146 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

EXCITABILITY C0235169

Relationships (1)

Relation Types:

diso_to_diso : 1

Relationships:

isa : 1

Relation Type	Co-Occuring Concept Count	Relationship	Concept
DISO_to_DISO		isa	O/E - excitable C1562285

Genes (26)

Species:

human : 26

Page Size

Current 25

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Current 1

Species	Gene	GeneId	Gene Name	Evidence
Human	KLHL1	57626	kelch-like family member 1	GENERIF, Score=861, Pubmed Id: 17289272, UMLKSK CUI: C0235169 modulatory effect of KLHL1 on the P/Q-type calcium channel function, suggesting a possible novel role for KLHL1 in cellular excitability
Human	PXK	54899	PX domain containing serine/threonine kinase	GENERIF, Score=861, Pubmed Id: 16135750, UMLKSK CUI: C0235169 MONaKA modulates brain Na,K-ATPase by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission [MONaKA]
Human	CACNA1G	8913	calcium channel, voltage-dependent, T type, alpha 1G subunit	GENERIF, Score=861, Pubmed Id: 11927664, UMLKSK CUI: C0235169 Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability
Human	STX1A	6804	syntaxin 1A (brain)	GENERIF, Score=861, Pubmed Id: 17506992, UMLKSK CUI: C0235169 the mechanisms involved in Syn1A-K(v) interactions vary significantly between K(v) channels, thus providing a wide scope for Syn1A modulation of exocytosis and membrane excitability
Human	SRC	6714	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	GENERIF, Score=861, Pubmed Id: 18617000, UMLKSK CUI: C0235169 Regulation of hERG channels by protein tyrosine kinases modifies the channel activity and thus likely alters electrophysiological properties including action potential duration and cell excitability in human heart and neurons
Human	SLC6A4	6532	solute carrier family 6 (neurotransmitter transporter), member 4	GENERIF, Score=861, Pubmed Id: 12130784, UMLKSK CUI: C0235169 results suggest that differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele
Human	SCN2A	6326	sodium channel, voltage-gated, type II, alpha subunit	GENERIF, Score=827, Pubmed Id: 17467289, UMLKSK CUI: C0235169 analysis of neonatal & adult splice forms of NaV1.2 with a benign familial neonatal-infantile seizures mutation; developmentally regulated NaV1.2 splicing may be one mechanism that counters the normally high excitability of neonatal neurons
Human	SCN1B	6324	sodium channel, voltage-gated, type I, beta subunit	GENERIF, Score=861, Pubmed Id: 17629415, UMLKSK CUI: C0235169 In summary, the mutant beta1 subunits essentially fail to modulate alpha subunits which could increase neuronal excitability and underlie GEFS+ pathogenesis GENERIF, Score=1000, Pubmed Id: 17604911, UMLKSK CUI: C0235169 Use of these Na+ channel models in simple neuron models revealed that both mutations(R85C, R85H) cause an increase in excitability but the R85H mutation was more excitable
Human	LEP	3952	leptin	GENERIF, Score=827, Pubmed Id: 12482897, UMLKSK CUI: C0235169 Leptin, via PI 3-kinase-driven activation of BK channels, elicits novel mechanism for controlling neuronal excitability
Human	KCNMA1	3778	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	GENERIF, Score=812, Pubmed Id: 18719396, UMLKSK CUI: C0235169 the evolutionarily preserved splicing of the Slo1 S6-RCK1 linker segment possess great potential to fine-tune neuronal excitability GENERIF, Score=827, Pubmed Id: 18345016, UMLKSK CUI: C0235169 common motif in the RCK1 domain of SLO1 mediates the stimulatory effects of both H+ and Ca2+, and provides a basis for the bidirectional coupling of cell metabolism and membrane electrical excitability
Human	KCNJ2	3759	potassium inwardly-rectifying channel, subfamily J, member 2	GENERIF, Score=861, Pubmed Id: 12459783, UMLKSK CUI: C0235169 effect of suppressing excitability in single neurons within a network of active hippocampal neurons by overexpressing an inward-rectifier potassium channel
Human	KCND3	3752	potassium voltage-gated channel, Shal-related subfamily, member 3	GENERIF, Score=861, Pubmed Id: 17506992, UMLKSK CUI: C0235169 the mechanisms involved in Syn1A-K(v) interactions vary significantly between K(v) channels, thus providing a wide scope for Syn1A modulation of exocytosis and membrane excitability
Human	KCND2	3751	potassium voltage-gated channel, Shal-related subfamily, member 2	GENERIF, Score=827, Pubmed Id: 16934482, UMLKSK CUI: C0235169 Electrophysiological analysis indicates attenuated K+ current density in cells expressing this Kv4.2-N587fsX1 mutant channel, which is consistent with a model of aberrant neuronal excitability characteristic of TLE
Human	KCNA3	3738	potassium voltage-gated channel, shaker-related subfamily, member 3	GENERIF, Score=861, Pubmed Id: 17854350, UMLKSK CUI: C0235169 The Kv1.3 potassium channel, postsynaptic density protein 95, and insulin receptor serine kinase co-localize to regulate membrane excitability and synaptic transmission at critical locations in the olfactory bulb
Human	KCNA1	3736	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	GENERIF, Score=861, Pubmed Id: 15486093, UMLKSK CUI: C0235169 coupling between calcium influx and inactivation of voltage-gated A-type K+ channels occurs as a result of membrane depolarization and may contribute to afterhyperpolarization as negative feedback to control neuronal excitability
Human	INSR	3643	insulin receptor	GENERIF, Score=861, Pubmed Id: 17854350, UMLKSK CUI: C0235169 Insulin receptor serine kinase, PSD-95, and the Kv1.3 potassium channel co-localize to regulate membrane excitability and synaptic transmission at critical locations in the olfactory bulb
Human	GRM1	2911	glutamate receptor, metabotropic 1	GENERIF, Score=861, Pubmed Id: 11951051, UMLKSK CUI: C0235169 In patients with mesial temporal lobe epilepsy, mGluR1 may increase hippocampal excitability through postsynaptic activation
Human	GPR35	2859	G protein-coupled receptor 35	GENERIF, Score=861, Pubmed Id: 17940199, UMLKSK CUI: C0235169 The results of the study demonstrate the coupling of GPR35 to endogenous G proteins that modulate neuronal Ca2+ channel and thereby provide evidence for a potential role of GPR35 in regulating neuronal excitability and synaptic transmission
Human	GABRE	2564	gamma-aminobutyric acid (GABA) A receptor, epsilon	GENERIF, Score=827, Pubmed Id: 17615250, UMLKSK CUI: C0235169 Increased intracortical excitability is noted in subjects affected by the GABA A receptor gamma 2 subunit (GABRG2 Arg43Glu) mutation; findings are likely to represent an important clue to mechanisms linking this gene defect and the epilepsy phenotype
Human	FECH	2235	ferrochelatase	GENERIF, Score=861, Pubmed Id: 17566985, UMLKSK CUI: C0235169 results highlight a novel, profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior
Human	CTTN	2017	cortactin	GENERIF, Score=812, Pubmed Id: 17959782, UMLKSK CUI: C0235169 cortactin-mediated actin remodeling in excitable cells is not only important for cell structure, but may directly impact membrane excitability
Human	DLG4	1742	discs, large homolog 4 (Drosophila)	GENERIF, Score=861, Pubmed Id: 17854350, UMLKSK CUI: C0235169 PSD-95, the Kv1.3 potassium channel, and insulin receptor serine kinase co-localize to regulate membrane excitability and synaptic transmission at critical locations in the olfactory bulb
Human	CLCN2	1181	chloride channel, voltage-sensitive 2	GENERIF, Score=861, Pubmed Id: 18801843, UMLKSK CUI: C0235169 propose that the function of the ClC-2 carboxy-terminus is to slow down the time course of channel activation in order to stabilize neuronal excitability
Human	APP	351	amyloid beta (A4) precursor protein	GENERIF, Score=861, Pubmed Id: 17785178, UMLKSK CUI: C0235169 Aberrant increases in network excitability and compensatory inhibitory mechanisms in the hippocampus may contribute to Abeta-induced neurological deficits in hAPP mice and, possibly, also in humans with AD
Human	APOE	348	apolipoprotein E	GENERIF, Score=861, Pubmed Id: 17293007, UMLKSK CUI: C0235169 The data suggest that neurophysiological endophenotype of non-demented individuals at genetic risk for AD, characterized by increased excitability and dysfunction of deep brain and alpha rhythm-generating structures

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C0235169	EXCITABILITY	0		self

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