Human | DAOA | 267012 | D-amino acid oxidase activator | The DAOA ARG30LYS is significant association with poor memory performance in schizophrenia |
Human | RTN4R | 65078 | reticulon 4 receptor | The molecular requirements for cerebral amyloid-beta peptide interaction with NgR are defined and correlated with the affinity of these polypeptides to improve spatial memory impairments in Alzheimer disease model mice |
Human | PDSS2 | 57107 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | |
Human | ADCK3 | 56997 | aarF domain containing kinase 3 | |
Human | APTX | 54840 | aprataxin | |
Human | COQ2 | 27235 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | |
Human | PDSS1 | 23590 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | |
Human | NCSTN | 23385 | nicastrin | Title:Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing|Association:Not Found|Conclusion:Therefore, the effect of Hap B in this sample is on the life-long stable trait of cognitive ability, and not on age-related cognitive change. The possibility that this result might be a selection effect was not supported by the samples being in Hardy-Weinberg equilibrium with respect to the distribution of NCSTN genotypes. |
Human | WWC1 | 23286 | WW and C2 domain containing 1 | the KIBRA genotype could affect memory performance in a different way in those that complain of memory deficits compared to those that do not |
Human | ALDH5A1 | 7915 | aldehyde dehydrogenase 5 family, member A1 | Title:A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability.|Association:Y|Conclusion:These data suggest that higher SSADH activity is associated with higher intelligence across the general population. The effect is small, with each allele having an effect size translating to about 1.5 IQ points. |
Human | TKT | 7086 | transketolase | |
Human | SPG7 | 6687 | spastic paraplegia 7 (pure and complicated autosomal recessive) | |
Human | SPAST | 6683 | spastin | |
Human | SOD1 | 6647 | superoxide dismutase 1, soluble | When transfected into mice, induces mitochondrial swelling, vacuolization, or learning and memory deficits |
Human | PSEN1 | 5663 | presenilin 1 | Title:Association between the presenilin-1 mutation Glu318Gly and complaints of memory impairment.|Association:Y|Conclusion:The presence of the Glu318Gly mutation was associated with significantly lower cognitive performance when compared to controls (P = 0.011). However, there was no significant association between the presence of the mutation and the cognitive performance of individuals within the memory complainers group. Follow-up studies should clarify whether the Glu318Gly mutation increases the risk of cognitive decline in later life. |
Human | PRNP | 5621 | prion protein | Title:M129V variation in the prion protein may influence cognitive performance.|Association:Not Found|Conclusion:In summary, we deliver evidence for an association of a common genetic variation in the prion protein gene with cognitive performance. However, independent replications are needed before firm conclusions can be drawn. |
Human | SERPINI1 | 5274 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Title:Poorer cognitive performance in humans with mild cognitive impairment carrying the T variant of the Glu/Asp NOS3 polymorphism.|Association:Not Found|Conclusion:These results suggest that the T allele is a genetic risk factor for cognitive impairment in the elderly. |
Human | HTR2A | 3356 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Title:Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.|Association:Not Found|Conclusion:We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory. This study investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant |
Human | GRM3 | 2913 | glutamate receptor, metabotropic 3 | extend putative brain dopaminergic and glutamatergic relationships indexed by catechol-O-methyltransferase and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia |
Human | ECM1 | 1893 | extracellular matrix protein 1 | |
Human | DRD4 | 1815 | dopamine receptor D4 | DRD4-7 was associated with poorer spatial working memory, and increasing blood lead levels were associated with impaired rule learning and reversal, spatial span, and planning, primarily for boys |
Human | DRD2 | 1813 | dopamine receptor D2 | an interaction of the DRD2 C957T and Catechol-O-Methyl-Transferase Val158Met may be involved in the generation of some working memory deficits in schizophrenia |
Human | COMT | 1312 | catechol-O-methyltransferase | extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and glutamate receptor metabotropic 3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia an interaction of the dopamine receptor D2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia |
Human | CHRNA7 | 1139 | cholinergic receptor, nicotinic, alpha 7 (neuronal) | These findings provide experimental evidence that nicotine effects an improvement in impaired memory, and that this improvement is associated with an increase in nAchRalpha7 |