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Details
Link-It Detail - Disease - Pituitary ACTH Hypersecretion
Debug Stats
  • ### Total Build Time: 17 ms 27.757 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 356 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 373 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 552 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=1 ms Completed: 1 ms rowSize= 2.790 KB
  • CONCEPT_RELATIONSHIPS gt=6 ms Completed: 6 ms rowSize= 8.230 KB
  • CONCEPT_GENES gt=6 ms Completed: 6 ms rowSize= 14.104 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.163 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Pituitary ACTH Hypersecretion C0221406
Definition (1)
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Hyperpituitarism C0020506
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076827img Hyperpituitarism C0020506
img Endocrine System Diseases C0014130img Pituitary Diseases C00320024img Hyperpituitarism C0020506
Relationships (19)

Relation Types:
diso_​to_​anat : 3
diso_​to_​chem : 4
diso_​to_​diso : 12


Relationships:
none : 16
associated_​with : 1
mapped_​to : 1
permuted_​term_​of : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO62img Complication Aspects C1171258
DISO_to_DISO61img Adenoma C0001430
DISO_to_ANAT53img In Blood C0005768
DISO_to_DISO53img Pituitary Neoplasms C0032019
DISO_to_DISO44img ACTH-Secreting Pituitary Adenoma C1306214
DISO_to_CHEM26img Hydrocortisone C0020268
DISO_to_ANAT24img In Blood C0005768
DISO_to_DISO23img Pituitary Neoplasms C0032019
DISO_to_CHEM21img Adrenocorticotropic Hormone C0001655
DISO_to_DISO20img Complication Aspects C1171258
DISO_to_DISO18img Adenoma C0001430
DISO_to_ANAT17img Pituitary Gland C0032005
DISO_to_DISO14img CANINE DIS C0012979
DISO_to_CHEM13img Deamino Arginine Vasopressin C0011701
DISO_to_DISO13img Cushing Syndrome C0010481
DISO_to_CHEM12img Somatostatin C0037659
DISO_to_DISOassociated_withimg Myopathy in Cushing disease C0270990
DISO_to_DISOpermuted_term_ofimg Pituitary ACTH Hypersecretion C0221406
DISO_to_DISOmapped_toimg Primary cortisol resistance C2930863
Genes (12)

Species:
human : 12
SpeciesGeneGeneIdGene NameEvidence
HumanGHRL51738ghrelin/obestatin prepropeptide
img GENERIF, Score=1000, Pubmed Id: 17280594, UMLKSK CUI: C0221406
img GENERIF, Score=1000, Pubmed Id: 15248830, UMLKSK CUI: C0221406
HumanAIP9049aryl hydrocarbon receptor interacting protein
img OMIM, Score=1000, UMLKSK CUI: C0221406
HumanSSTR56755somatostatin receptor 5
img OMIM, Score=1000, UMLKSK CUI: C0221406
HumanSMARCA46597SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
img GENERIF, Score=1000, Pubmed Id: 17043312, UMLKSK CUI: C0221406
HumanPRKAR1A5573protein kinase, cAMP-dependent, regulatory, type I, alpha
img OMIM, Score=1000, UMLKSK CUI: C0221406
HumanPOMC5443proopiomelanocortin
img GENERIF, Score=1000, Pubmed Id: 18057378, UMLKSK CUI: C0221406
img GENERIF, Score=1000, Pubmed Id: 17043312, UMLKSK CUI: C0221406
HumanMEN14221multiple endocrine neoplasia I
img GAD, Score=1000, Pubmed Id: 14678300, UMLKSK CUI: C0221406
HumanHDAC23066histone deacetylase 2
img GENERIF, Score=1000, Pubmed Id: 17043312, UMLKSK CUI: C0221406
HumanNR3C12908nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
img GENERIF, Score=1000, Pubmed Id: 17043312, UMLKSK CUI: C0221406
HumanGNAS2778GNAS complex locus
img OMIM, Score=1000, UMLKSK CUI: C0221406
HumanCDKN2A1029cyclin-dependent kinase inhibitor 2A
img GENERIF, Score=1000, Pubmed Id: 15014032, UMLKSK CUI: C0221406
HumanKLK3354kallikrein-related peptidase 3
img GENERIF, Score=1000, Pubmed Id: 12398228, UMLKSK CUI: C0221406
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0221406Pituitary ACTH Hypersecretion0self