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Details
Link-It Detail - Disease - Yellow Nail Syndrome
Debug Stats
  • ### Total Build Time: 37 ms 18.755 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 338 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 414 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 244 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=6 ms Completed: 6 ms rowSize= 1.822 KB
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=9 ms Completed: 9 ms rowSize= 5.423 KB
  • CONCEPT_RELATIONSHIPS gt=12 ms Completed: 12 ms rowSize= 6.259 KB
  • CONCEPT_GENES gt=4 ms Completed: 4 ms rowSize= 3.089 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Yellow Nail Syndrome C0221348
Definition (1)
A rare syndrome characterized by the presence of thickened yellow nails, lymphedema, and respiratory abnormalities, including pleural effusion, bronchiectasis, chronic sinusitis, and persistent cough. Some cases are associated with mutations in the FOXC2 gene.
Semantic Types (2)
Pathologic Function (T046)
Disease or Syndrome (T047)
Parents (4)
img Nails, Malformed C0027344
img Nail Diseases C0027339
img Genetic Diseases, Inborn C0950123
img Pigmentation Disorders C0549567
Ancestral Roots
RootRoot Plus OneDepthParent
img Pathological Conditions, Signs and Symptoms C0039058img Pathological Conditions, Anatomical C07521354img Nails, Malformed C0027344
img Skin and Connective Tissue Diseases C0175166img Skin Diseases C00372744img Nail Diseases C0027339
img Congenital, Hereditary, and Neonatal Diseases and Abnormalities C0027612img Genetic Diseases, Inborn C09501233img Genetic Diseases, Inborn C0950123
img Skin and Connective Tissue Diseases C0175166img Skin Diseases C00372744img Pigmentation Disorders C0549567
Relationships (13)

Relation Types:
diso_​to_​diso : 13


Relationships:
none : 3
manifestation_​of : 8
mapped_​to : 1
permuted_​term_​of : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO13img Complication Aspects C1171258
DISO_to_DISO4img Acquired lymphedema C0024236
DISO_to_DISO3img Pleural Effusion C0032227
DISO_to_DISOmanifestation_ofimg Allelic disorders with overlapping phenotypes include hereditary lymphedema type II (153200), lymphedema and ptosis (153000), and the lymphedema-distichiasis syndrome (153400) C1835241
DISO_to_DISOmanifestation_ofimg Caused by mutation in the forkhead box C2 gene (FOXC2, 602402.0007) C1835240
DISO_to_DISOmanifestation_ofimg Excessively curved nails C1835239
DISO_to_DISOpermuted_term_ofimg Hereditary lymphedema and yellow nails C0221348
DISO_to_DISOmapped_toimg Lymphedema of the lower extremities, recurrent pneumonia, bronchiectasis, and yellowed nails C2931921
DISO_to_DISOmanifestation_ofimg Lymphedema, predominantly in the lower limbs C1835228
DISO_to_DISOmanifestation_ofimg Lymphography shows hypoplasia of lymphatic vessels C1835249
DISO_to_DISOmanifestation_ofimg Onset of lymphedema around puberty C1835229
DISO_to_DISOmanifestation_ofimg Slow-growing nails C1835238
DISO_to_DISOmanifestation_ofimg Yellow nails C1768507
Genes (1)

Species:
human : 1
SpeciesGeneGeneIdGene NameEvidence
HumanFOXC22303forkhead box C2 (MFH-1, mesenchyme forkhead 1)
img OMIM, Score=1000, UMLKSK CUI: C0221348
img OMIM, Score=983, UMLKSK CUI: C0221348
img OMIM, Score=983, UMLKSK CUI: C0221348
img OMIM, Score=1000, UMLKSK CUI: C0221348
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0221348Yellow Nail Syndrome0self