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Genes (12)
Species: human : 12 | |
Human | SENP1 | 29843 | SUMO1/sentrin specific peptidase 1 | Together, the constitutional t(12;15)(q13;q25) translocation revealed two novel candidate genes for neonatal/infantile GCT development: MESDC2 and SENP1. | Human | CHEK2 | 11200 | checkpoint kinase 2 | As DNA breaks occur commonly during gametogenesis, and p53 is wild-type and overexpressed in testicular cancer, we examined abundance and localisation of the Chk2 protein during normal development of human testes, and at various stages of germ-cell tumour (GCT) pathogenesis. | Human | BCL10 | 8915 | B-cell CLL/lymphoma 10 | The association between four BCL10 single nucleotide polymorphisms at codons 5, 8, 162, and intron 1 and the susceptibility or progression for germ cell tumors (GCTs) was investigated in 73 testicular GCT patients and 72 controls. | Human | TFF1 | 7031 | trefoil factor 1 | We examined TFF-1 expression using immunohistochemistry on formalin-fixed, paraffin-embedded sections of 49 gastrointestinal carcinoids; 15 pancreatic islet cell tumors; 21 paragangliomas; 8 medullary thyroid carcinomas; 7 small cell carcinomas of the uterine cervix; 4 prostate, 4 bladder, and 6 Merkel cell (primary cutaneous neuroendocrine) carcinomas; and 1 renal carcinoma No gastrointestinal carcinoid tumor, pancreatic islet cell tumor, paraganglioma, or Merkel cell carcinoma expressed TFF-1. | Human | NOTCH1 | 4851 | notch 1 | In the present study, we found that Notch1 is not detectable in human GI carcinoid tumor cells. In the present study, we found that Notch1 is not detectable in human GI carcinoid tumor cells. | Human | GRPR | 2925 | gastrin-releasing peptide receptor | CONCLUSIONS: GRP and GRPR are produced by a large number of gastrointestinal carcinoid tumours. AIMS: To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours. | Human | FGR | 2268 | feline Gardner-Rasheed sarcoma viral oncogene homolog | This study examines the expression of the co-activators SRC-1a/e, SRC-2, SRC-3, SRA, and the corepressors NCoR and SMRT in GCT, epithelial ovarian tumours and normal ovary. | Human | CDK6 | 1021 | cyclin-dependent kinase 6 | In the GCT cell lines in which cyclin D2 was highly expressed, cyclin D2 was in complex with its expected catalytic partners (Cdk4 and Cdk6). | Human | ASCL1 | 429 | achaete-scute complex homolog 1 (Drosophila) | Results: Among a panel of six developmental transcription factors tested, only Ascl1 mRNA was overexpressed compared with surrounding normal tissue (seven of 10 GI carcinoid tumors and in BON cells, none of five normal tissues). | Human | RHOB | 388 | ras homolog family member B | PATIENTS AND METHODS: The mRNA levels of the RhoA, RhoB and RhoC genes were analysed in the surgical specimens of testicular GCT tissues from 45 consecutive Japanese patients, and in the corresponding unaffected tissue originating from the same patient, using reverse transcription-polymerase chain reaction. | Human | APAF1 | 317 | apoptotic peptidase activating factor 1 | The region containing APAF1 was found to be deleted in GCT by fluorescence in situ hybridization analysis, but without evidence of coding sequence alterations. RT-PCR and Western blot analysis showed APAF1 gene expression at detectable levels in all GCT cell lines analyzed. We further localized the gene between the polymorphic markers D12S1671 and D12S1082 at 12q22 to determine the role of APAF1 in the pathogenesis of GCT, and we characterized its normal genomic structure and analyzed its alterations in GCTs. | Human | ALCAM | 214 | activated leukocyte cell adhesion molecule | First, immunohistological analyses revealed that some of the same markers, detected by the SH2, SH3, and SH4 antibodies and the CD166 antigen, were found in GCT stromal cells as in the first developmental stages of osteoblast differentiation from the initial MSCs. |
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