Genes (25)
Species:
human : 25 | |
| Human | AKAP13 | 11214 | A kinase (PRKA) anchor protein 13 | Prophylactic gastrectomy is potentially a lifesaving procedure and clinical breast screening is recommended for asymptomatic mutation carriers. | | Human | CHEK2 | 11200 | checkpoint kinase 2 | There was no significant overall association between CHEK2 and breast cancer (OR = 1.3; p = 0.30), but among those with lobular carcinoma the association with the I157T missense mutation was very strong (OR = 6.6; p > 0.0001). | | Human | LYVE1 | 10894 | lymphatic vessel endothelial hyaluronan receptor 1 | To address this important issue, the present study investigated the lymphatics in primary human breast carcinoma (75 cases of invasive ductal and lobular breast cancer) by quantitative immunohistochemical staining for the lymphatic endothelial hyaluronan receptor LYVE-1, the blood vascular marker CD34, and the nuclear proliferation marker pKi67. | | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | In addition, all seven lobular breast cancer samples tested did not express HMGI-C. | | Human | TXN | 7295 | thioredoxin | Nuclear thioredoxin positivity was more often found in in situ lesions, and lobular carcinomas were more often negative than ductal ones. | | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | human breast tumours aberrantly express significantly higher levels of COX2; lobular carcinomas had a higher level of COX2 than ductal carcinomas | | Human | PLAUR | 5329 | plasminogen activator, urokinase receptor | uPAR of cancerous cells was more often observed in lobular carcinomas | | Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | exon 9 PIK3CA mutations are typical of infiltrating lobular carcinomas | | Human | NKX3-1 | 4824 | | CONCLUSIONS: Expression of NKX3.1 is highly restricted and is found primarily in benign and malignant prostatic epithelial cells and also in normal testis and lobular carcinoma of the breast. Expression of NKX3.1, a member of the NK-class of homeodomain, is highly restricted and is found primarily in lobular carcinoma. Expression of NKX3.1 is highly restricted and is found primarily in benign and malignant prostatic epithelial cells and also in normal testis and lobular carcinoma of the breast | | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | MMP9 is downregulated in lobular carcinoma in situ compated with normal breast epithelium and stroma | | Human | LIMS1 | 3987 | LIM and senescent cell antigen-like domains 1 | METHODS: A polyclonal antibody was raised to a purified 6-histidine PINCH fusion protein and used to evaluate 74 cases comprising 33 breast carcinomas (21 ductal carcinomas, 6 lobular carcinomas, 4 ductal carcinomas in situ, 2 lobular carcinomas in situ), 22 prostate carcinomas, 5 colon carcinomas, 6 lung carcinomas (3 adenocarcinomas and 3 squamous carcinomas), and 8 skin carcinomas (4 basal cell carcinomas and 4 squamous cell carcinomas) by immunoperoxidase histochemistry of formalin-fixed, paraffin-embedded tissues. | | Human | JUP | 3728 | junction plakoglobin | These results indicate that simultaneous loss of E-cadherin and alpha-, beta- and gamma-catenin may be an important step in the formation of lobular carcinoma in situ, as a precursor of invasive lobular breast cancer. Expression patterns of E-cadherin and the molecules comprising the cytoplasmic complex of adherens junctions, alpha-, beta- and gamma-catenin, were studied in a series of 38 lobular breast carcinomas with known E-cadherin mutation status. | | Human | HMGA1 | 3159 | high mobility group AT-hook 1 | Because HMGA1 expression was similar among ductal breast carcinomas with different histologic grading, we evaluated the association between HMGA1 expression and that of other markers of breast carcinoma invasion (estrogen and progesterone receptors, Ki-67 antigen, and ErbB2) in 21 cases of grade 3 breast ductal carcinomas and 7 cases of breast lobular carcinomas. We measured, by immunohistochemistry, HMGA1 protein expression in 212 breast tissue specimens: 6 normal samples, 28 hyperplastic lesions (13 with cellular atypia), 11 fibroadenomas, 10 in situ ductal carcinomas, 144 ductal carcinomas, and 13 lobular carcinomas. | | Human | HIF1A | 3091 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Oestrogen and progesterone receptors, tumour proliferative activity, the expression of cyclin A, p16(ink4A), p27(kip1), p21(waf1), p53, bcl-2, and levels of vascular endothelial growth factor and hypoxia-inducible factor-1alpha (HIF-1alpha) were evaluated in 190 in ductal and 67 lobular carcinomas. Conversely, no significant difference was found between lobular carcinomas and in ductal carcinomas considering the frequency distribution of PgR-positive cases, cyclin-dependent kinase inhibitors acting at the G1/S boundary, bcl-2 and HIF-1alpha protein expression. | | Human | FLT1 | 2321 | fms-related tyrosine kinase 1 | Only a single tumour, a lobular carcinoma, failed to express Flt-1 on either cell type. | | Human | FH | 2271 | fumarate hydratase | To further evaluate the role of FH in tumorigenesis, we screened FH mutations from tumor types seen in hereditary leiomyomatosis and renal cell cancer mutation carriers-41 uterine and 10 cutaneous leiomyomas, 52 renal cell carcinomas, 53 sarcomas, 29 prostate carcinomas, and 15 lobular breast carcinomas. | | Human | CTNND1 | 1500 | catenin (cadherin-associated protein), delta 1 | Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. In a search for signaling molecules that act downstream of E-cadherin inactivation in cancer, we examined the expression and localization of E-cadherin-associated proteins in lobular carcinoma, in which the E-cadherin gene is frequently inactivated, and found that E-cadherin down-regulation correlated with the cytoplasmic localization of p120ctn. | | Human | CLDN4 | 1364 | claudin 4 | Claudin 4 is downregulated in lobular carcinoma in situ compated with normal breast epithelium and stroma | | Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | Click here to display 17 evidence detail records. | | Human | CD36 | 948 | CD36 molecule (thrombospondin receptor) | In this regard, the coexpression of TSP1 and CD36 may, in part at least, account for the variably invasive behavior of lobular carcinoma cells. | | Human | BRCA2 | 675 | breast cancer 2, early onset | For BRCA2 mutation, an association with tubular/lobular carcinoma has been suggested, but not substantiated in a larger Breast Cancer Linkage Consortium study. | | Human | NR0B1 | 190 | nuclear receptor subfamily 0, group B, member 1 | METHODS: In this study we evaluated, by immunohistochemistry and Western blot analysis, the presence and distribution of DAX-1 in benign breast disease (BBD), in situ carcinoma (CIS), and ductal and lobular breast carcinomas. | | Human | ACACA | 31 | acetyl-CoA carboxylase alpha | All cases of non-infiltrating as well as infiltrating ductal and lobular carcinomas were reactive with the above-mentioned antisera, although a marked variation both in the proportion of cells stained within a tumour and in the intensity of staining of the cells was noted; the immunoreactivity showed a diffuse cytoplasmic pattern but sometimes nuclear with CaMp and ACC-1, while ACAP-1 exhibited mostly a cytoplasmic perinuclear granular expression; the same immunohistochemical pattern for CaM and CaM activated forms was observed also in metastatic elements present in axillary lymph nodes. | | Human | SERPINA3 | 12 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | The elastosis of 11 invasive ductal and infiltrative lobular carcinomas of the breast was specifically immunostained for the plasma protease inhibitors alpha-1 antitrypsin, alpha-1 antichymotrypsin, alpha-2 macroglobulin, inter alpha trypsin inhibitor and C1 esterase inhibitor. | | Human | NAT1 | 9 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | One protein, the expression of which was elevated in invasive ductal and lobular breast carcinomas when compared with normal breast tissue, was arylamine N-acetyltransferase-1 (NAT-1), a Phase II drug-metabolizing enzyme. |
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