Genes (32)
Species: human : 32 | |
Human | DCUN1D1 | 54165 | DCN1, defective in cullin neddylation 1, domain containing 1 | Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas. | Human | MSLN | 10232 | mesothelin | The carcinomas that did not express mesothelin included renal cell carcinomas, hepatomas, carcinomas of the thyroid, adrenal cortical carcinomas, prostatic adenocarcinomas, and carcinoid tumors. | Human | WT2 | 7491 | Wilms tumor 2 | | Human | UROD | 7389 | uroporphyrinogen decarboxylase | Organ porphyrins and uroporphyrinogen decarboxylase activity in a case of non-functioning adrenocortical carcinoma. The correlation between the reduced activity of uroporphyrinogen decarboxylase and the increased concentration of uroporphyrin was noted in the adrenocortical carcinoma and its metastases to the liver and lymph node, and also in the bone marrow and renal medulla. | Human | TP53 | 7157 | tumor protein p53 | The TP53 R337H mutation dramatically increases predisposition to childhood adrenocortical carcinoma (ACT) but not to other cancers, and explains the increased frequency of ACT observed in this geographic region pH-sensitive molecular defect of p53 (R337H)suggests that pH-dependent p53 dysfunction is the molecular basis for cases of adrenocortical carcinoma in Brazilian children Germline p53 mutation is associated with adrenocortical carcinoma and subsequent osteosarcoma Adrenocortical carcinomas | Human | NKX2-1 | 7080 | | Comparison of thyroid transcription factor-1 and hepatocyte antigen immunohistochemical analysis in the differential diagnosis of hepatocellular carcinoma, metastatic adenocarcinoma, renal cell carcinoma, and adrenal cortical carcinoma. | Human | TGFBR2 | 7048 | transforming growth factor, beta receptor II (70/80kDa) | reduced transforming growth factor-beta type II receptor expression may play a critical role in determining the malignant phenotype of human adrenocortical carcinoma | Human | NR2F2 | 7026 | nuclear receptor subfamily 2, group F, member 2 | In adrenocortical tumors, COUP-TFII immunoreactivity was marked in the nuclei of tumor cells of aldosteroma (H score, 134 +/- 15.9; P _lt_ 0.001 vs. Cushing;s adenoma and P _lt_ 0.05 vs. nonfunctioning adenoma and carcinoma), modest in nonfunctioning adenoma (82.7 +/- 19.8) and adrenocortical carcinoma (79.6 +/- 56.3), and low in Cushing;s adenoma (38.2 +/- 24.5). | Human | SYP | 6855 | synaptophysin | EXPERIMENTAL DESIGN: Archival, formaldehyde-fixed, and paraffin-embedded material comprising 27 adrenocortical carcinomas (ACC, meeting Weiss; histologic criteria), 28 pheochromocytomas (PCC), and adjacent nontumorous tissue (13 glands) were analyzed by immunogold-silver staining for the expression of polysialic acid (poly Sia), cytokeratins (CK), synaptophysin (SYN), chromogranin A (CrgA), somatostatin (SOM), calcitonin (CT), and the ;adrenocortical marker; D11. Overlapping expression of immunohistochemical markers and synaptophysin mRNA in pheochromocytomas and adrenocortical carcinomas. RESULTS. With synaptophysin, NSE, and vimentin there was focal staining in only few zona glomerulosa cells in the normal adrenal cortex, whereas adrenocortical carcinomas and adenomas were extensively positive for these proteins. | Human | SCP2 | 6342 | sterol carrier protein 2 | The mRNA concentrations of SCP2 in two out of three adrenocortical carcinomas were relatively lower than those in other types of tissue. | Human | PLCB3 | 5331 | phospholipase C, beta 3 (phosphatidylinositol-specific) | RESULTS: We show that the PLCB3 transcript is missing in 8 out of 14 MEN1-associated neoplasias as well as in 4 out of 10 bronchial carcinoids, 2 out of 10 exocrine pancreatic cancers and one sporadic adrenocortical carcinoma. | Human | MUC5AC | 4586 | mucin 5AC, oligomeric mucus/gel-forming | Many carcinomas can exhibit distinct MUC1, MUC2, and MUC5AC expression patterns, which might be valuable diagnostically in specific settings (eg, distinguishing cholangiocarcinoma from hepatocellular carcinoma or renal from adrenocortical carcinoma). | Human | IRS1 | 3667 | insulin receptor substrate 1 | We found that IRS-1 is constitutively activated in a variety of solid tumors, including breast cancers, leiomyomas, Wilms; tumors, rhabdomyosarcomas, liposarcomas, leiomyosarcomas, and adrenal cortical carcinomas. | Human | INHA | 3623 | inhibin, alpha | Immunolabeling for the inhibin alpha subunit is potentially useful in the differential diagnosis of neoplasms that include adrenal cortical carcinomas. To study the role of inhibins in human adrenal gland, we screened a panel of 150 adrenals (10 normal adrenals, 25 adrenocortical hyperplasias, 65 adrenocortical adenomas, 30 adrenocortical carcinomas and 20 phaeochromocytomas) for inhibin alpha expression. | Human | IGFBP2 | 3485 | insulin-like growth factor binding protein 2, 36kDa | In hormonally active adrenocortical carcinomas, IGFBP-2, -4, -5 and -6 mRNA levels were lower than in nonfunctional carcinomas and normal adrenals. In addition to IGF-II overexpression, increased levels of the IGF-I-receptor and IGFBP-2 have been found in advanced human adrenocortical carcinomas, suggesting an important role for the IGF-system in adrenocortical carcinogenesis. The xenografts precisely reproduced the dysregulation of the insulin-like growth factor (IGF) system [overexpression of the IGF-II and IGF-binding protein-2 (IGFBP-2) genes] typical of adrenocortical carcinoma. Circulating markers specific for adrenocortical carcinoma are needed and the aim of this study was to evaluate plasma IGFBP-2 as a marker for these malignant tumors. Similarly to adrenocortical carcinomas, human IGFBP-2 (but not IGF-II) was secreted in mouse plasma. However, plasma IGFBP-2 was less sensitive than expected for a tumor marker, which may limit its value in the diagnosis and follow-up of adrenocortical carcinoma. Increased concentrations of insulin-like growth factor-binding protein-2 (IGFBP-2) have been observed in human malignancies including adrenocortical carcinomas. | Human | IGF2R | 3482 | insulin-like growth factor 2 receptor | IGF-IR expression was significantly higher in pediatric adrenocortical carcinomas than adenomas, whereas its expression was similar in adult adrenocortical carcinomas and adenomas | Human | GATA6 | 2627 | GATA binding protein 6 | GATA-6 mRNA was expressed in 19/19 adenomas and 9/10 carcinomas, and GATA-6 immunoreactivity was remarkably lower in adrenocortical carcinomas than in adenomas (p < 0.05). In striking contrast to this, GATA-6 was absent from murine adrenocortical tumors, while GATA-4 mRNA expression was dramatically upregulated in the murine adrenal tumors as well as in human adrenocortical carcinomas. In contrast to GATA-6, we found upregulated cyclin-dependent kinase inhibitor p21 and proliferation marker Ki67 in adrenocortical carcinomas indicating that GATA-6 is not linked to cell proliferation in human adrenal tumors. GATA-6 mRNA and protein expression was remarkably diminished in adrenocortical carcinomas as compared to normal adrenal cortex and adenomas (p<0.05). | Human | GATA4 | 2626 | GATA binding protein 4 | In striking contrast to this, GATA-6 was absent from murine adrenocortical tumors, while GATA-4 mRNA expression was dramatically upregulated in the murine adrenal tumors as well as in human adrenocortical carcinomas. Analogous results were obtained with human tissue samples; GATA-4 expression was detected in human adrenocortical carcinomas but not in normal tissue, adenomas, or pheochromocytomas. | Human | NR5A1 | 2516 | nuclear receptor subfamily 5, group A, member 1 | Ad4BP/SF-1 and DAX-1 are expressed not only in benign adrenal adenoma but also malignant adrenocortical carcinoma, it is useful to distinguish from other retroperitoneal tumors | Human | FGF4 | 2249 | fibroblast growth factor 4 | Using adrenal cortical carcinoma cells genetically engineered to express FGF-4, we have tested cellular survival following exposure to ionizing radiation. | Human | FGF1 | 2246 | fibroblast growth factor 1 (acidic) | This study reports on the effects of heparin, basic and acidic fibroblast growth factors (bFGF and aFGF, respectively), and transforming growth factor type-e (TGFe) on the growth of a human adrenocortical carcinoma cell line, SW-13. We studied the different potentials of a secreted and a nonsecreted member of the fibroblast growth factor (FGF) family to induce autocrine growth stimulation in human adrenal cortex carcinoma cells (SW-13). | Human | ESR2 | 2100 | estrogen receptor 2 (ER beta) | Adrenal cortical carcinomas are character- ized by an imbalance between estrogen receptor alpha and estrogen receptor beta levels and increased aromatase expression | Human | CYP21A2 | 1589 | cytochrome P450, family 21, subfamily A, polypeptide 2 | The formation of steroids in the H295R human adrenocortical carcinoma cell line was analysed by HPLC or RIA, and based on these data the apparent catalytic activities of CYP11A, CYP17, CYP21 and CYP11B1 in this cell line were calculated. | Human | CYP11B2 | 1585 | cytochrome P450, family 11, subfamily B, polypeptide 2 | Autocrine-paracrine role of endothelin-1 in the regulation of aldosterone synthase expression and intracellular Ca2+ in human adrenocortical carcinoma NCI-H295 cells. | Human | CYP11B1 | 1584 | cytochrome P450, family 11, subfamily B, polypeptide 1 | The formation of steroids in the H295R human adrenocortical carcinoma cell line was analysed by HPLC or RIA, and based on these data the apparent catalytic activities of CYP11A, CYP17, CYP21 and CYP11B1 in this cell line were calculated. |
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