Human | AGRN | 375790 | agrin | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | ENPP7 | 339221 | ectonucleotide pyrophosphatase/phosphodiesterase 7 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | TUBA1C | 84790 | tubulin, alpha 1c | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | MUC3B | 57876 | mucin 3B, cell surface associated | Expression of MUC1, MUC2, and MUC3 core tandem repeat proteins was examined in specimens of normal mucosa (n = 20), hyperplastic polyps (n = 10), adenomatous polyps (n = 89), and invasive cancer (n = 19). We conclude that enhanced immunoreactivity of MUC1, MUC2 and MUC3 mucin tandem repeats occurs in adenomatous polyps and is associated with an increased risk for malignant transformation. |
Human | CTNNBIP1 | 56998 | catenin, beta interacting protein 1 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | ATP8A2 | 51761 | ATPase, aminophospholipid transporter, class I, type 8A, member 2 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | ANAPC2 | 29882 | anaphase promoting complex subunit 2 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | PPP1R15A | 23645 | protein phosphatase 1, regulatory subunit 15A | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | HTATIP2 | 10553 | HIV-1 Tat interactive protein 2, 30kDa | CC3 and CC4 are expressed earlier in the evolution of adenomatous polyps. |
Human | APC2 | 10297 | adenomatosis polyposis coli 2 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | DOCK4 | 9732 | dedicator of cytokinesis 4 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | GDF15 | 9518 | growth differentiation factor 15 | There was a progressive increase in serum MIC-1 levels between normal individuals [mean (M) = 495 pg/ml, SD = 210), those with adenomatous polyps (M = 681 pg/ml, SD = 410), and those with CRC (M = 783 pg/ml, SD = 491)]. The normal range for serum MIC-1 levels was defined in 260 healthy blood donors, and the differences between normal subjects and 193 patients having adenomatous polyps or CRC were then determined. |
Human | KLF4 | 9314 | Kruppel-like factor 4 (gut) | In the current study, we demonstrated that GKLF mRNA levels were significantly decreased in the dysplastic epithelium of the colon, including adenomatous polyp and cancer. |
Human | DNAJA3 | 9093 | DnaJ (Hsp40) homolog, subfamily A, member 3 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | IQGAP1 | 8826 | IQ motif containing GTPase activating protein 1 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | SRPX | 8406 | sushi-repeat containing protein, X-linked | down-regulation of drs mRNA is closely correlated with carcinomas which arise from adenomatous polyps in the course of the adenoma-carcinoma sequence, but most carcinomas arising de novo are independent of the tumor suppressor function of the drs gene |
Human | PLA2G10 | 8399 | phospholipase A2, group X | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | PLA2G6 | 8398 | phospholipase A2, group VI (cytosolic, calcium-independent) | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | FZD7 | 8324 | frizzled family receptor 7 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | AXIN2 | 8313 | axin 2 | The present study of intact human colon crypts, adenomatous polyps, and adenocarcinomas focuses on subcellular localization of some key elements of the complex: beta-catenin, APC, axin, and axin2. |
Human | AXIN1 | 8312 | axin 1 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | REEP5 | 7905 | receptor accessory protein 5 | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | Notably, CXCR4 was significantly over-expressed in cancerous lesions (carcinomas and metastasis) compared to non-cancerous lesions (normal mucosa and polyps) (P=0.003) and in adenomatous polyps versus hyperplastic polyps (P=0.009). |
Human | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | INFERRED, Score=800, UMLKSK CUI: C0206677 |
Human | WNT1 | 7471 | wingless-type MMTV integration site family, member 1 | INFERRED, Score=800, UMLKSK CUI: C0206677 |