Genes (35)
Species: human : 35 | |
Human | UCN3 | 114131 | urocortin 3 | Ucn and CRF receptors were all expressed in the tumor cells of pheochromocytomas, adrenocortical adenomas, and carcinomas, but its positivity was less than that in nonpathological adrenal glands, suggesting that Ucn1, Ucn3, and CRF receptors were down-regulated in these adrenal neoplasms. | Human | NCOR2 | 9612 | nuclear receptor corepressor 2 | We therefore examined the expression of COUP-TFI, SF-1, SRC-1, N-CoR, and SMRT in a variety of adrenocortical adenomas and compared the results with CYP17 mRNA levels. Therefore, we compared the expression of COUP-TFI, N-CoR and SMRT in non-hyperfunctioning adrenocortical adenomas and normal adrenal glands. | Human | NCOR1 | 9611 | nuclear receptor corepressor 1 | These results indicate that COUP-TFI and N-CoR may play a role in steroidogenesis by human adrenocortical adenomas. Therefore, we compared the expression of COUP-TFI, N-CoR and SMRT in non-hyperfunctioning adrenocortical adenomas and normal adrenal glands. We therefore examined the expression of COUP-TFI, SF-1, SRC-1, N-CoR, and SMRT in a variety of adrenocortical adenomas and compared the results with CYP17 mRNA levels. | Human | NCOA1 | 8648 | nuclear receptor coactivator 1 | We therefore examined the expression of COUP-TFI, SF-1, SRC-1, N-CoR, and SMRT in a variety of adrenocortical adenomas and compared the results with CYP17 mRNA levels. | Human | NR2F1 | 7025 | nuclear receptor subfamily 2, group F, member 1 | COUP-TFI expression in human adrenocortical adenomas: possible role in steroidogenesis. Therefore, we compared the expression of COUP-TFI, N-CoR and SMRT in non-hyperfunctioning adrenocortical adenomas and normal adrenal glands. We did not detect the expected negative correlation between COUP-TFI and CYP17 mRNA levels in adrenocortical adenomas. We therefore examined the expression of COUP-TFI, SF-1, SRC-1, N-CoR, and SMRT in a variety of adrenocortical adenomas and compared the results with CYP17 mRNA levels. To explore novel transcriptional coregulators for COUP-TFs, we used the COUP-TFI as bait in a yeast two-hybrid screen of an adrenocortical adenoma cDNA library. These results indicate that COUP-TFI and N-CoR may play a role in steroidogenesis by human adrenocortical adenomas. | Human | SYP | 6855 | synaptophysin | Surgery revealed the presence of an adrenal cortical adenoma with positive staining for the neuroendocrine marker synaptophysin, but negative for chromogranin, as has been previously reported for these rare cortical phaeochromocytomas. Lack of atypias and absence of mucin markers, together with an immunophenotype consistent with adrenal tumours (focal cytokeratin, vimentin, synaptophysin and alpha-inhibin immunoreactivities), led to a diagnosis of primary adrenocortical adenoma with an extensive pseudoglandular myxoid pattern. | Human | SULT2A1 | 6822 | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | In cortices attached to adrenocortical adenomas, SULT2A1 mRNA expression was present mainly in zona reticularis and extended to zona fasciculata | Human | STAR | 6770 | steroidogenic acute regulatory protein | Data show that StAR mRNA was found throughout the whole adrenal cortex attached to adrenocortical adenomas, but not in the medulla | Human | PRKAR1A | 5573 | protein kinase, cAMP-dependent, regulatory, type I, alpha | Interestingly allelic loss at 17p13 and 11p15 have been observed in sporadic adrenocortical cancer and somatic PRKAR1A mutations in secreting adrenocortical adenomas. | Human | PGR | 5241 | progesterone receptor | PR concentrations were high in normal adrenal and adrenal tissues adjacent to adrenocortical adenoma, and were even higher in tumors carcinoma - and in isolated primary pigmented nodular adrenocortical disease | Human | MC2R | 4158 | melanocortin 2 receptor (adrenocorticotropic hormone) | In cortices attached to adrenocortical adenomas, MC2R mRNA was expressed faintly in zona fasciculata and zona reticularis | Human | INHA | 3623 | inhibin, alpha | [The expression of A103 and inhibin alpha in adrenocortical adenoma by high-throughput tissue microarray techniques] The combined use of A103 and inhibin alpha is valuable in distinguishing adrenocortical adenoma from pheochromocytoma and other metastatic carcinomas. To study the role of inhibins in human adrenal gland, we screened a panel of 150 adrenals (10 normal adrenals, 25 adrenocortical hyperplasias, 65 adrenocortical adenomas, 30 adrenocortical carcinomas and 20 phaeochromocytomas) for inhibin alpha expression. OBJECTIVE: To evaluate the potential diagnostic role of A103 and inhibin alpha in adrenocortical adenoma and the feasibility of tissue microarray/tissue chips. 51 of 61(83.6%) adrenocortical adenomas reacted with inhibin alpha. | Human | HSD11B2 | 3291 | hydroxysteroid (11-beta) dehydrogenase 2 | 11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas | Human | HSD3B2 | 3284 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | In cortices attached to adrenocortical adenomas, HSD3B2 mRNA was expressed in zona glomerulosa and zona fasciculata, but only sporadically in zona reticularis | Human | HCRTR2 | 3062 | hypocretin (orexin) receptor 2 | All adrenal cortex adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas | Human | HCRTR1 | 3061 | hypocretin (orexin) receptor 1 | All adrenal corttex adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas As was expected, according to the results obtained in normal tissues, cortical tumours (adrenocortical adenomas) were positive for OX1R but not for OX2R and conversely, medullar tumours (pheochromocytomas) expressed only OX2R. | Human | GSTA1 | 2938 | glutathione S-transferase alpha 1 | We, therefore, hypothesize that overexpression of GSTA1 in adrenocortical adenomas might be involved in the growth of tumor cells. | Human | GNAS | 2778 | GNAS complex locus | isolated hyperfunctioning thyroid and adrenal adenomas displayed the mutation on the maternal and paternal alleles, respectively | Human | GHRH | 2691 | growth hormone releasing hormone | Human pancreatic growth hormone releasing hormone fails to stimulate human growth hormone both in Cushings disease and in Cushings syndrome due to adrenocortical adenoma. | Human | GATA6 | 2627 | GATA binding protein 6 | We have now analyzed GATA-6 expression in 20 human adrenocortical adenomas and 16 carcinomas using Northern blot analysis and immunohistochemistry. | Human | NR5A1 | 2516 | nuclear receptor subfamily 5, group A, member 1 | Ad4BP/SF-1 and DAX-1 are expressed not only in benign adrenal adenoma but also malignant adrenocortical carcinoma, it is useful to distinguish from other retroperitoneal tumors | Human | MLANA | 2315 | melan-A | However, here we report the presence of immunoreactivity for A103, an antibody to Melan-A, in five adrenocortical adenomas, 16 primary and 13 metastatic adrenocortical carcinomas, four Leydig cell tumors of the testis, and three Sertoli-Leydig cell tumors of the ovary. | Human | ESR2 | 2100 | estrogen receptor 2 (ER beta) | ERbeta transcript levels were very high in all samples of adrenocortical adenoma, normal adrenal cortex and primary pigmented nodular adrenocortical disease except those for two cardinoma, whereas aromatase levels were low | Human | ESR1 | 2099 | estrogen receptor 1 | ERalpha concentrations were low in normal adrenal gland, in adrenal tissues adjacent to adrenocortical ademoma, in carcinoma, and lower in adrenocortical adenoma | Human | ERV3 | 2086 | endogenous retrovirus group 3, member 1 | First, the ERV3 mRNA was demonstrated at different levels in organs, and at consistently high levels in adrenal glands from all individuals and in all adrenocortical adenomas examined, by Northern hybridization. |
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