Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Title:Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification.|Association:Y|Conclusion:This study provides genetic evidence linking CCR2 with coronary atherosclerosis in humans. |
Human | FAM83H | 286077 | family with sequence similarity 83, member H | FAM83H mutations in families with autosomal-dominant hypocalcified amelogenesis imperfecta demonstrate that FAM83H is required for proper dental-enamel calcification |
Human | NCRNA00219 | 114915 | | vascular calcification-associated factor (VCAF) is present in human calcified arteries but not noncalcified arteries |
Human | VKORC1 | 79001 | vitamin K epoxide reductase complex, subunit 1 | Persons with at least one 1173C>T-allele had a statistically significant 19% (95% CI 2 to 40%) risk increase of calcification of the aortic far wall compared to CC homozygous persons, adjusted for age and gender |
Human | XYLT2 | 64132 | xylosyltransferase II | Calcifications (atrial and ventricular endocardium) |
Human | XYLT1 | 64131 | xylosyltransferase I | Calcifications (atrial and ventricular endocardium) |
Human | ANKH | 56172 | ANKH inorganic pyrophosphate transport regulator | Polyarticular chondrocalcinosis (cartilage calcification) |
Human | ODAM | 54959 | odontogenic, ameloblast asssociated | Calcifying epithelial odontogenic tumor-associated amyloid consists of a unique and previously undescribed protein that we provisionally designate APin |
Human | SAMD9 | 54809 | sterile alpha motif domain containing 9 | PIvotal role in calcification and thus implicated in various hereditary diseases such as atherosclerosis, calcinosis and autoimmune diseases Calcified, ulcerating nodules SAMD9 may have a role in the TNF-alpha signaling pathway and in the regulation of extra-osseous calcification |
Human | KIF1B | 23095 | kinesin family member 1B | Mediastinal mass with calcifications on radiology Abdominal mass with calcifications on radiology |
Human | TREX1 | 11277 | three prime repair exonuclease 1 | Bilateral, symmetric intracerebral calcifications, especially in the basal ganglia and periventricular areas |
Human | DHS | 10774 | dehydrated hereditary stomatocytosis | Systemic artery calcification |
Human | SLC34A2 | 10568 | solute carrier family 34 (type II sodium/phosphate contransporter), member 2 | Intraalveolar nodular calcifications ('microliths') |
Human | GCM2 | 9247 | glial cells missing homolog 2 (Drosophila) | Intracerebral calcification on CT scan |
Human | PHOX2B | 8929 | paired-like homeobox 2b | Mediastinal mass with calcifications on radiology Abdominal mass with calcifications on radiology |
Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | RANKL-OPG pathway may regulate valvular calcification in calcific aortic stenosis |
Human | TNF | 7124 | tumor necrosis factor | SAMD9 may have a role in the TNF-alpha signaling pathway and in the regulation of extra-osseous calcification |
Human | TGM2 | 7052 | transglutaminase 2 | externalized GTP-bound TG2 serves as a molecular switch for differentiation of chondrocytes to a hypertrophic, calcifying phenotype in a manner that does not require either TG2 transamidation activity or fibronectin binding |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease |
Human | SPP1 | 6696 | secreted phosphoprotein 1 | Osteopontin as well as dystrophy within the tumor may be involved in the stromal calcification of large cell neuroendocrine carcinoma |
Human | SLC20A1 | 6574 | solute carrier family 20 (phosphate transporter), member 1 | An overexpression of Pit-1 seems to play a key role in the formation of soft tissue calcification in Werner syndrome |
Human | SELE | 6401 | selectin E | Title:Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcification.|Association:Y|Conclusion:The significant association between E-selectin and CAC in women 50 years of age or younger may suggest that the 128R allele is a risk factor for coronary atherosclerosis in younger asymptomatic women, who typically have lower levels of traditional risk factors and reduced adhesion molecule expression due to the presence of higher levels of endogenous hormones. |
Human | S100A9 | 6280 | S100 calcium binding protein A9 | Report showed S100A9 was expressed human bone and cartilage cells and may contribute to calcification of the cartilage matrix and its replacement with trabecular bone, and to regulation of redox in bone resorption |
Human | S100A8 | 6279 | S100 calcium binding protein A8 | Report showed S100A8 was expressed human bone and cartilage cells and may contribute to calcification of the cartilage matrix and its replacement with trabecular bone, and to regulation of redox in bone resorption |
Human | PTH | 5741 | parathyroid hormone | Intracerebral calcification on CT scan |