Human | SCGB3A2 | 117156 | secretoglobin, family 3A, member 2 | results suggest that the -112G/A polymorphism does not play a significant role in the genetic predisposition of the UGRP1 gene in atopic asthma in the Sicilian population |
Human | ORMDL3 | 94103 | ORM1-like 3 (S. cerevisiae) | a significant association between susceptibility to childhood atopic asthma and the polymorphism regulating ORMDL3 expression in a Japanese population |
Human | IL25 | 64806 | interleukin 25 | Blocking IL-25 in an experimental model of allergic asthma prevents airway hyperresponsiveness, a critical feature of clinical asthma |
Human | IL21 | 59067 | interleukin 21 | study provides evidence that IL21 is associated with atopic asthma, TsIgE and serum IL-21 levels |
Human | TBX21 | 30009 | T-box 21 | An association between a specific TBX21 haplotype and allergic asthma in children is demonstrated for the first time |
Human | CHIA | 27159 | chitinase, acidic | results establish a significant association of CHIA with atopic asthma and serum total IgE levels in the Indian population |
Human | HAVCR1 | 26762 | hepatitis A virus cellular receptor 1 | Polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population |
Human | OPN3 | 23596 | opsin 3 | Polymorphisms in the OPN3 and CHML genes are associated with asthma and atopic asthma |
Human | CCR9 | 10803 | chemokine (C-C motif) receptor 9 | CCR9 is selectively expressed on abnormal asthmatic T cell receptor (TCR) Valpha24-positive invariant natural killer T (iNKT) cells, inducing a TH2 bias in T cells that is at least partially critical for the pathogenesis of allergic asthma |
Human | TNFRSF14 | 8764 | tumor necrosis factor receptor superfamily, member 14 | sHVEM levels were elevated in sera of patients with allergic asthma, atopic dermatitis and rheumatoid arthritis |
Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | The data supports the hypothesis that gene modulation by IL-13 in ASM may be essential for the events leading to the development of allergic asthma |
Human | TJP1 | 7082 | tight junction protein 1 | Rsults suggest that the lower epithelial alpha-catenin, E-cadherin and (or) ZO-1 expression in patients with atopic asthma contributes to a defective airway epithelial barrier and a higher influx of eosinophils in the epithelium |
Human | TGFB2 | 7042 | transforming growth factor, beta 2 | TGF-beta(2) may therefore be involved in the development of childhood atopic asthma by means of functional genetic polymorphism |
Human | XCL1 | 6375 | chemokine (C motif) ligand 1 | XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma |
Human | CCL18 | 6362 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | A new function for CCL18--the recruitment of Th2 cells and basophils--suggests that CCL18 may play a predominant role in allergic asthma |
Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | Title:|Association:Not Found|Conclusion:Not Found |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | the C allele of CD14 & the 4G allele of SERPINE1 were encountered more in house dust mite-allergic asthmatic patients than controls; results indicate PAl-1 & CD14 may interact to affect susceptibility to allergic asthma |
Human | PAFAH1B1 | 5048 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | Val279Phe polymorphism is activity-deficient and is associated with increased risk of childhood atopic asthma Title:|Association:Y|Conclusion:Not Found Title:|Association:Y|Conclusion:Not Found |
Human | NTF4 | 4909 | neurotrophin 4 | Data suggest that activation of bronchial eosinophils by neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophins-3 and -4) might play a role in the regulation of eosinophilic inflammation in allergic asthma |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | eNOS overexpression attenuates both airway inflammation and airway hyperresponsiveness in a transgenic mouse model of allergic asthma |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 17 polymorphisms associated with the risk of childhood atopic asthma were identified in MMP-9 |
Human | LTA | 4049 | lymphotoxin alpha | LT-alpha-Ncol*1 may be a risk factor for atopic asthma in Taiwanese children |
Human | LAMA5 | 3911 | laminin, alpha 5 | The uncoordinated production of chains of ln-5 in allergic asthma could have a bearing on the poor epithelial cell anchorage in these patients |
Human | ITK | 3702 | IL2-inducible T-cell kinase | In transgenic mice specifically lacking Itk kinase activity, active kinase signaling is required for control of T helper (Th)2 cell responses and development of allergic asthma |
Human | IL16 | 3603 | interleukin 16 | an influence of genetic variability at the promoter of IL-4 gene (-590C>T) and a coding region of IL-13 gene (R130Q) on the occurrence of allergic asthma and no relationship between IL-16 promoter polymorphism (-295T>C) and this disease |