Genes (57)
Species: human : 57 | |
Human | NKX6-2 | 84504 | | Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors. | Human | BIRC6 | 57448 | baculoviral IAP repeat containing 6 | Apollon protein was expressed in four of six brain cancers (gliomas), and one of five ovarian cancers in 38 human cancer cell lines that we examined. Among the brain cancer cell lines, SNB-78 expressed a high level of Apollon, and this cell line shows resistance against various anticancer drugs. A human IAP-family gene, apollon, expressed in human brain cancer cells. | Human | PANX2 | 56666 | pannexin 2 | According to brain cancer gene expression database REMBRANDT, PANX2 expression levels can predict post diagnosis survival for patients with glial tumors | Human | BCCIP | 56647 | BRCA2 and CDKN1A interacting protein | Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Furthermore, expression of BCCIPalpha inhibits breast and brain cancer cell growth, but fails to inhibit HT1080 cells and a non-transformed human skin fibroblast. | Human | TNFRSF12A | 51330 | tumor necrosis factor receptor superfamily, member 12A | To determine the biological role of Fn14 in brain cancer progression, we examined the activity of Fn14 as a potential mediator of cell survival. | Human | GLTSCR1 | 29998 | glioma tumor suppressor candidate region gene 1 | Title:Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas.|Association:Y|Conclusion:These results suggested that alterations in GLTSCR1 (or a closely linked gene) were associated with the development and progression of oligodendroglioma. | Human | EPB41L3 | 23136 | erythrocyte membrane protein band 4.1-like 3 | The ERM subgroup member merlin/schwannomin is inactivated in the tumor-predisposition syndrome neurofibromatosis 2 (NF2), and the prototypic 4.1 subgroup member, Protein 4.1B, has been implicated in the molecular pathogenesis of breast, lung and brain cancers. | Human | ADAMTS13 | 11093 | ADAM metallopeptidase with thrombospondin type 1 motif, 13 | We found mild ADAMTS-13 deficiency in 17/80 tumor patients, but there was no significant difference in ADAMTS-13 activity between the age- and sex-matched patients with benign and malignant brain tumors nor between the age matched patients with local and metastatic prostate tumors. To investigate the relevance of ADAMTS-13 for tumor progression, we determined ADAMTS-13 activity and VWF:Ag in 80 patients with various malignancies: 30 patients with benign brain tumors, 30 patients with malignant brain tumors, 10 patients with local prostate tumors and 10 patients with metastatic prostate tumors. No significant difference in ADAMTS-13 activity between the age- and sex-matched patients with benign and malignant brain tumors nor between the age matched patients with prostatic cancer | Human | GLIPR1 | 11010 | GLI pathogenesis-related 1 | We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. | Human | SPTLC1 | 10558 | serine palmitoyltransferase, long chain base subunit 1 | In the present study, based on evidence that indicates subunit 1 of serine palmitoyltransferase, SPT1, interacts with Hsp90, both ligand-induced Cyp1A1 transactivation and capacity for proliferation were evaluated using the wild type Glioma LN18 human brain cancer cell line and its recombinant counterparts expressing green fluorescent SPT1 fusion proteins. | Human | LGI1 | 9211 | leucine-rich, glioma inactivated 1 | Its localization to the 10q24 region, and rearrangements or inactivation in malignant brain tumors, suggest that LGI1 is a candidate tumor suppressor gene involved in progression of glial tumors. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. | Human | SART1 | 9092 | squamous cell carcinoma antigen recognized by T cells | Generation of a human leukocyte antigen-A24-restricted antitumor cell with the use of SART-1 peptide and dendritic cells in patients with malignant brain tumors. | Human | IER3 | 8870 | immediate early response 3 | Of particular interest are: FGF9 which may stimulate the growth of prostate cancer, brain cancer and endometrium; and IER3 (IEX-1), PHLDA2 (TSS3), IAPP (amylin), and SST, all of which may play roles in apoptosis. | Human | TMEFF1 | 8577 | transmembrane protein with EGF-like and two follistatin-like domains 1 | This protein may behave as a tumor suppressor gene in brain cancers These data suggest that TMEFF1 may behave as a tumor suppressor gene in brain cancers. Interestingly, ectopic expression of TMEFF1 in brain cancer cells resulted in their growth inhibition. | Human | RAD54L | 8438 | RAD54-like (S. cerevisiae) | Title:Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker.|Association:Not Found|Conclusion:The statistical analysis of genotypes at the 2290C/T polymorphism suggest an association between the rare T allele and the development of meningeal tumours. This polymorphism can be used as a genetic marker inside the consensus deletion region at 1p32 in meningiomas. | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | As medulloblastomas (MBs), the most common malignant brain tumors of childhood, are believed to arise from neuronal cerebellar precursors, we asked whether there is a potential role for Cxcr4 in the pathogenesis of MB. These studies (i) demonstrate that CXCR4 is critical to the progression of diverse brain malignances and (ii) provide a scientific rationale for clinical evaluation of AMD 3100 in treating both adults and children with malignant brain tumors. | Human | XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3 | Title:Polymorphisms of DNA repair genes and risk of glioma.|Association:Not Found|Conclusion:These results suggest that the T allele may be a risk allele, and this XRCC7 polymorphism may be a marker for the susceptibility to glioma. Larger studies are needed to confirm our findings and unravel the underlying mechanisms. | Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | Title:Polymorphisms of DNA repair genes and risk of glioma.|Association:Not Found|Conclusion:These results suggest that the T allele may be a risk allele, and this XRCC7 polymorphism may be a marker for the susceptibility to glioma. Larger studies are needed to confirm our findings and unravel the underlying mechanisms. | Human | TP53 | 7157 | tumor protein p53 | Title:Polymorphisms of DNA repair genes and risk of glioma.|Association:Not Found|Conclusion:These results suggest that the T allele may be a risk allele, and this XRCC7 polymorphism may be a marker for the susceptibility to glioma. Larger studies are needed to confirm our findings and unravel the underlying mechanisms. | Human | TMF1 | 7110 | TATA element modulatory factor 1 | Interestingly, the level of TMF/ARA160 was significantly decreased in malignant brain tumors, implying a suppressive role of that protein in tumor progression. Interestingly, the level of TMF/ARA160 was significantly decreased in malignant brain tumors, implying a suppressive role of that protein in tumor progression. | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | Our studies suggest that TIMP-2 expressing the defective HSV vector is possibly useful for the treatment of malignant brain tumors. | Human | TFRC | 7037 | transferrin receptor (p90, CD71) | The mouse TRFR MAb enables transport across the tumor vasculature, which is of mouse brain origin, and the INSR MAb causes transport across the plasma membrane and the nuclear membrane of the human brain cancer cell. | Human | SLC2A1 | 6513 | solute carrier family 2 (facilitated glucose transporter), member 1 | hnRNP A2 acts on GLUT1 mRNA to inhibit expression of GLUT1 in a brain cancer cell line | Human | SHH | 6469 | sonic hedgehog | The sonic hedgehog (Shh) and the Wnt signalling pathways are involved in the development of medulloblastomas (MBs), the most frequent malignant brain tumours in children. | Human | RAD51 | 5888 | RAD51 recombinase | Title:Polymorphisms of DNA repair genes and risk of glioma.|Association:Not Found|Conclusion:These results suggest that the T allele may be a risk allele, and this XRCC7 polymorphism may be a marker for the susceptibility to glioma. Larger studies are needed to confirm our findings and unravel the underlying mechanisms. |
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