Genes (280)
Species: human : 276 mouse : 4 | |
Mouse | TLE1 | 7088 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | We generated Grg1 and Grg5 transgenic mice and found that Grg1 overexpression induces lung adenocarcinoma, whereas Grg5 overexpression does not. | Mouse | ROBO1 | 6091 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Mice with a targeted deletion within one Dutt1/Robo1 allele spontaneously develop lymphomas and carcinomas in their second year of life with a 3-fold increase in incidence compared with controls: invasive lung adenocarcinomas are by far the predominant carcinoma. | Mouse | OSM | 5008 | oncostatin M | To examine the efficacy of this HRE-Egr-OSM gene therapy in vivo, the tumor suppression effects were investigated in 40 nude mice bearing lung adenocarcinoma xenograft. [Oncostatin M gene therapy in mice bearing lung adenocarcinoma xenograft using a hypoxia/radiation dual-sensitive promoter] OBJECTIVE: To improve the efficacy of radiogenetic therapy for lung cancer, a hypoxia/radiation dual-sensitive promoter was constructed to enhance the expression of oncostatin M (OSM) in transfected cells exposed to radiation under hypoxia. [Oncostatin M gene therapy in mice bearing lung adenocarcinoma xenograft using a hypoxia/radiation dual-sensitive promoter] | Mouse | ABCA1 | 19 | ATP-binding cassette, sub-family A (ABC1), member 1 | RT-PCR revealed mRNA and Western blotting demonstrated protein for the ATP binding cassette A1 (ABCA1) transporter in mouse FS, TtT/GF, and A549 lung adenocarcinoma cells from which glucocorticoids also induce externalization of ANXA1. | Human | CSAG2 | 728461 | CSAG family, member 2 | Induction of TRAG-3 expression in A549 lung adenocarcinoma cell line by 5-aza-2; deoxyazacytidine. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Whereas interest in GGT has centered in the past on experimental hepatocarcinogenesis, the current results demonstrate an ectopic expression of GGT in metaplastic alveolar cells and in adenocarcinoma of the lung. The mesotheliomas, irrespective of cell type or grade, showed lower gamma-glutamyl transpeptidase (GGT) concentration than 36 of the 38 pulmonary adenocarcinomas. | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | Thirty-four primary lung adenocarcinomas were examined by in situ hybridization for mucin gene expression (MUC1-4, MUC5AC, MUC5B, MUC6-7) and by immunohistochemistry for MUC5AC and MUC5B apomucin expression. Mucinous bronchioloalveolar carcinoma (BAC) had a homogeneous pattern of mucin gene expression different from those of other types of lung adenocarcinoma, involving secreted mucins (MUC5AC, MUC5B, and MUC6) and membrane-bound mucins (MUC1, MUC3, and MUC4). | Human | ACTR3C | 653857 | ARP3 actin-related protein 3 homolog C (yeast) | Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. We recently reported the isolation of a novel actin-related gene, Arp11, from a PC-14 human lung adenocarcinoma clone with low metastatic and tumorigenic ability. Expression of the Arp11 gene may regulate the metastatic potential of PC-14 human lung adenocarcinoma. | Human | SFTPA1 | 653509 | surfactant protein A1 | Click here to display 50 evidence detail records. | Human | XAGE1B | 653220 | X antigen family, member 1B | Click here to display 5 evidence detail records. | Human | LCA10 | 643736 | lung carcinoma-associated protein 10 | LCAP levels were most commonly elevated (62.7%) in patients with adenocarcinoma of the lung and with advanced disease. | Human | CXorf61 | 203413 | chromosome X open reading frame 61 | Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma. | Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Ets-1 appears to be a useful predictor of poor prognosis after surgical resection in lung adenocarcinoma patients [Ets-1 proto oncogene] | Human | ASB8 | 140461 | ankyrin repeat and SOCS box containing 8 | The growth characteristics of the lung adenocarcinoma SPC-A1 cells expressing either exogenous ASB-8 or ASB-8 SB (SOCS box-deficient) was studied by both in vitro cell growth curve and in vivo nude mouse tumor formation assay. [Exogenous expression of SOCS box-deficient mutant ASB-8 suppresses the growth of lung adenocarcinoma SPC-A1 cells] | Human | HIST3H2BB | 128312 | histone cluster 3, H2bb | The inhibitory effect of histone H2B on the activity of HB4C5 antibody to immunostain the cytoplasmic antigen in lung adenocarcinoma tissue indicated that histone H2B at least had antigenic determinant comparable to the cytoplasmic antigen. | Human | STK11IP | 114790 | serine/threonine kinase 11 interacting protein | observations provide complete information about the pattern and levels of LKB1 & p-acetyl-CoA carboxylase immunostaining in normal tissues and in lung tumors, and highlight the special relevance of abnormalities of the LKB1 pathway in lung adenocarcinoma | Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | In lung adenocarcinomas, the expression of HIN-1 correlated with cellular differentiation status. | Human | FAM83A | 84985 | family with sequence similarity 83, member A | BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (68.8%). | Human | MFSD2A | 84879 | major facilitator superfamily domain containing 2A | Case-only association study on SNPs mapping in TRIT1 and MFSD2 indicated that the rare Leu allele (frequency: 0.04) of the TRIT1 Phe202Leu variation predicts short survival as compared to the common Phe/Phe genotype (hazard ratio (HR)=1.7; 95% CI, 1.03-2.86; P=0.039) in 335 Italian lung adenocarcinoma samples. | Human | TUBA1C | 84790 | tubulin, alpha 1c | In human lung adenocarcinoma cells exposed to vinblastine (VLB) and stained with fast green, large tubulin crystals were seen in the cytoplasm. | Human | CDK5RAP3 | 80279 | CDK5 regulatory subunit associated protein 3 | it is concluded that CDK5RAP3, CCNB2, and RAGE genes may be used as a very reliable biomarkers of lung adenocarcinoma | Human | FAM57A | 79850 | family with sequence similarity 57, member A | Transcript of CT120 was not detectable in normal lung tissue, but was abundant in SPC-A-1 (human epithelial-like lung adenocarcinoma) cell line, suggesting that CT120 may be involved in lung cancer development. | Human | CDCP1 | 64866 | CUB domain containing protein 1 | CUB-domain-containing protein 1 (CDCP1), is identified as an Src family kinases-binding phosphoprotein associated with the anchorage independence of human lung adenocarcinoma | Human | MUC3B | 57876 | mucin 3B, cell surface associated | Mucinous bronchioloalveolar carcinoma (BAC) had a homogeneous pattern of mucin gene expression different from those of other types of lung adenocarcinoma, involving secreted mucins (MUC5AC, MUC5B, and MUC6) and membrane-bound mucins (MUC1, MUC3, and MUC4). In contrast, lung adenocarcinomas, especially well-differentiated cancers, exhibited increased MUC1, MUC3, and MUC4 mRNA levels. | Human | ACTR3B | 57180 | ARP3 actin-related protein 3 homolog B (yeast) | Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. We recently reported the isolation of a novel actin-related gene, Arp11, from a PC-14 human lung adenocarcinoma clone with low metastatic and tumorigenic ability. Expression of the Arp11 gene may regulate the metastatic potential of PC-14 human lung adenocarcinoma. |
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