Human | MIA2 | 117153 | melanoma inhibitory activity 2 | Data indicate that MIA2 represents a potential novel acute phase protein and MIA2 expression responds to liver damage in chronic liver diseases |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | soluble TRAIL in the HBV infected people may participate in the liver damage |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta1 may play a dual role in HBV infection, in the suppression of immune responses against viral infection and in the direct inhibition of viral replication, resulting in minimization of liver damage in patients with chronic hepatitis |
Human | SHH | 6469 | sonic hedgehog | Hedgehog signaling is conserved in hepatic progenitors from fetal development through adulthood and may be a new therapeutic target in patients with liver damage |
Human | CX3CL1 | 6376 | chemokine (C-X3-C motif) ligand 1 | the fractalkine system is up-regulated during liver damage, and suggests that fractalkine may play a role in the recruitment and adhesion of inflammatory cells and in the biology of liver epithelial cells |
Human | RELA | 5970 | v-rel avian reticuloendotheliosis viral oncogene homolog A | Selective suppression of RELA in hepatitis virus-infected pregnant women manifesting severe liver damage and high mortality |
Human | PON1 | 5444 | paraoxonase 1 | Data suggest that oxidative stress seems to suppress PON1 synthesis in hepatosteatosis patients, and that oxidative stress and oxidant-antioxidant imbalance may be part of the cytotoxic mechanisms leading to liver cell injury |
Human | SERPINA1 | 5265 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | AAT mutations are associated with hyperferritinemia and sinusoidal iron accumulation, but not with more severe liver damage in NAFLD |
Human | ABCB4 | 5244 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | No chronic or permanent liver damage |
Human | PDCD1 | 5133 | programmed cell death 1 | PD-1 up-regulation may efficiently mitigate pathogenic CD8 T-cell responses and liver damage, correlating with disease progression of acute hepatitis b virus infection |
Human | LTB | 4050 | lymphotoxin beta (TNF superfamily, member 3) | The identification of IL-6 and IL-1beta as activators of LT-beta supports their involvement in LT-beta signaling in liver regeneration associated with chronic liver damage |
Human | CXCL10 | 3627 | chemokine (C-X-C motif) ligand 10 | Elevated IP-10 levels are associated with and may contribute to liver damage in both HCV-monoinfected and HCV/HIV-coinfected patients |
Human | HMOX1 | 3162 | heme oxygenase (decycling) 1 | These data suggest that HCV core protein may contribute to hepatocellular injury by increasing both steady-state levels of prooxidants and the susceptibility of hepatocytes to damage by impairing their response to other sources of oxidative stress |
Human | HMGB1 | 3146 | high mobility group box 1 | In contrast to the proinflammatory role of HMGB1 in hepatic ischemia/reperfusion (I/R), pretreatment of mice with recombinant human HMGB1 significantly decreases liver damage after I/R In liver transplantation, HMGB1 originates from the graft and is a marker of hepatocellular injury |
Human | HGF | 3082 | hepatocyte growth factor (hepapoietin A; scatter factor) | Recombinant human HGF accelerates the regeneration of severely damaged livers, a situation in which the proliferation of mature hepatocytes is impaired HGF electrogene therapy would prevent liver from radiation-induced liver damage by preventing apoptosis and down-regulation of TGF-beta1 |
Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | There are no relationship between GSTT1 and GSTM1 gene deletions and hepatic damage caused by HBV Polymorphisms affecting the activity of the glutathione S-transferase isoform T1 may be associated with the risk of developing chronic severe ethanol liver damage |
Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | Polymorphisms affecting the activity of the glutathione S-transferase isoform M1 may be associated with the risk of developing chronic severe ethanol liver damage |
Human | FGF7 | 2252 | fibroblast growth factor 7 | Expression of keratinocyte growth factor was significantly increased in damaged liver tissue in correlation to the degree of fibrosis |
Human | CD58 | 965 | CD58 molecule | The level of CD58 molecule (in both serum and PBMC form) of patients with hepatitis B is related to the degree of liver damage |
Human | FASLG | 356 | Fas ligand (TNF superfamily, member 6) | results indicate that the -844C > T polymorphism is not related with the susceptibility to hepatitis C virus infection, the severity of liver damage and the progression of fibrosis in our cohort of Spanish patients |
Human | APOE | 348 | apolipoprotein E | Changes of HDL-cholesterol and apo-AI/apo-E mRNA ratio could be a good indicator of liver damage and/or hepatic functional recovery post-orthotopic liver transplantation |