|Mouse||SLC6A4||6532||solute carrier family 6 (neurotransmitter transporter), member 4|
These results suggest that oral carcinoma may suppress 5-HTT gene expression in the central nervous system, perhaps in relation with decreased plasma leptin level.
|Mouse||PTK2||5747||protein tyrosine kinase 2|
Enhanced FAK immunostaining is detected in small populations of preinvasive (carcinoma in situ) oral cancers and in large populations of cells in invasive oral cancers.
expression may be associated with the progression of oral carcinoma and poor patient outcomes
Site-specific subgroup analysis further showed that copy number gains of CCNL1 and SNO occurred more frequently in oral carcinomas in advanced clinical stages as compared to N0 oral lesions (CCNL1: P=0.03; SNO: P=0.03).
|Human||RRM2B||50484||ribonucleotide reductase M2 B (TP53 inducible)|
Moreover, we assessed the possibility that p53R2 would be a good molecular target, and report that RNAi targeting of p53R2 could be useful for oral cancer gene therapy.
Silencing of the p53R2 gene by RNA interference inhibits growth and enhances 5-fluorouracil sensitivity of oral cancer cells.
|Human||MYCBP||26292||MYC binding protein|
We found that mRNAs encoding for cyclophilin A, c-myc binding protein 1, the heat shock protein 90alpha and one unknown transcript were up-regulated in the oral cancer cell lines analysed as well as in HOK-16B cells.
|Human||LY96||23643||lymphocyte antigen 96|
Our clinical examination in oral cancer patients also suggests the requirement of both TLR4 and MD-2 in the OK-432-induced anti-cancer host response.
|Human||BTG3||10950||BTG family, member 3|
Analysis of the ANA gene as a candidate for the chromosome 21q oral cancer susceptibility locus.
These findings demonstrate that there may be at least 2 distinct TSGs on 21q11.1; loss of ANA gene expression could be involved in the progression of human OSCC; and aberrant methylation of the ANA gene promoter may participate in the transcriptional silencing of the gene in oral cancer cells.
|Human||POSTN||10631||periostin, osteoblast specific factor|
Here, we demonstrated that Periostin overexpression enhanced invasiveness in oral cancer cell lines.
In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients.
Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer.
|Human||ZEB2||9839||zinc finger E-box binding homeobox 2|
Results suggest that SIP1 contributes to the loss of E-cadherin expression and that detection of SIP1 expression is a predictive and prognostic tool in clinical management of oral carcinomas
|Human||SART3||9733||squamous cell carcinoma antigen recognized by T cells 3|
Click here to display 5 evidence detail records.
|Human||RIN1||9610||Ras and Rab interactor 1|
RIN1 appears to be a valuable probe for investigating the process of gene amplification in general and, specifically, 11q13 amplification in oral cancer.
|Human||CXCL14||9547||chemokine (C-X-C motif) ligand 14|
results indicate that BRAK/CXCL14 is a chemokine, having suppressive activity toward tumor progression of oral carcinoma in vivo
|Human||GDF15||9518||growth differentiation factor 15|
In summary, some NSAIDs induce NAG-1 expression in oral cavity cancer cells and the induced NAG-1 protein appears to mediate apoptosis.
We have investigated whether NAG-1 is induced in oral cavity cancer cells by various NSAIDs and if apoptosis induced by NSAIDs can be linked directly with the induction of NAG-1.
|Human||EBAG9||9166||estrogen receptor binding site associated, antigen, 9|
These results suggest that RCAS1 expression might be associated with progression of oral tumors and offer a possible mechanism for oral cancer immune escape.
|Human||RPL14||9045||ribosomal protein L14|
Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers.
Significant tumour specific methylation of cyclin A1 promoter seen in oral sqmaous cell carcinoma
|Human||TP63||8626||tumor protein p63|
The aim of this study was to investigate the biologic role of p63 in oral tumorigenesis and its possible role as prognostic marker in oral cancer.
Neither staining pattern nor percentage of stained cells could be used to differentiate the lesions studied.
These data suggest that p63 expression may be useful to identify cases of oral squamous cell carcinoma with more aggressive and invasive phenotype providing novel diagnostic and prognostic information on individual patient survival with oral cancers.
CONCLUSIONS: We conclude that p63 is expressed in oral carcinomas and dysplasias, as determined by immunohistochemical staining with a primary antibody to all isotypes.
|Human||LMO4||8543||LIM domain only 4|
The LMO4 gene is overexpressed in breast cancer and oral cavity carcinomas, and high levels of this protein inhibit mammary epithelial differentiation.
|Human||SLC7A5||8140||solute carrier family 7 (amino acid transporter light chain, L system), member 5|
These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.
|Human||CDK2AP1||8099||cyclin-dependent kinase 2 associated protein 1|
Click here to display 5 evidence detail records.
|Human||HMGA2||8091||high mobility group AT-hook 2|
HMGA2 overexpression is associated with aggressiveness of oral carcinoma
These results suggest that HMGA2 contributes to the aggressiveness of carcinoma and that detection of HMGA2 expression is a useful predictive and prognostic tool in clinical management of oral carcinomas.
|Human||XRCC5||7520||X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)|
Altered expression of DNA double-strand repair genes Ku70 and Ku80 in carcinomas of the oral cavity.
The main aim of this study was to analyse the expression of the heterodimers Ku70 and Ku80, building regulatory subunits of the DNA-dependent protein kinase in 40 oral carcinomas.
|Human||VCAM1||7412||vascular cell adhesion molecule 1|
Correspondingly, VCAM-1 and E-selectin were significantly increased in laryngeal carcinoma, whereas only E-selectin was elevated in oral carcinoma.
To establish whether the 5T4 oncofoetal antigen can serve as a tumour-specific marker for oral cancer and precancer, we have evaluated the pattern of expression on biopsies of normal, inflamed and dysplastic oral mucosa using immunohistochemistry.