Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | Title:Polymorphisms of genes involved in innate immunity:association with preterm delivery|Association:Not Found|Conclusion:The overall influence of the investigated polymorphisms on the development of preterm delivery seems moderate, since only the maternal IL6-174G genotype was associated with preterm birth and none of the polymorphisms were associated with intrauterine infection as the cause of preterm birth. |
Human | PNPO | 55163 | pyridoxamine 5'-phosphate oxidase | |
Human | LGALS13 | 29124 | lectin, galactoside-binding, soluble, 13 | Decreased levels of PP13 (placental protein 13) were not significantly correlated with the studied adverse pregnancy outcomes of intrauterine growth restriction, preterm delivery, low birth weight, and intrauterine fetal demise |
Human | SLC17A5 | 26503 | solute carrier family 17 (acidic sugar transporter), member 5 | |
Human | ZMPSTE24 | 10269 | zinc metallopeptidase STE24 | |
Human | SLC23A1 | 9963 | solute carrier family 23 (ascorbic acid transporter), member 1 | Findings link genetic variants in the vitamin C transporter gene SLC23A1 to spontaneous preterm birth |
Human | SLC23A2 | 9962 | solute carrier family 23 (ascorbic acid transporter), member 2 | Findings link genetic variants in the vitamin C transporter gene SLC23A2 to spontaneous preterm birth |
Human | GDF15 | 9518 | growth differentiation factor 15 | amniotic fluid MIC-1 is derived from the fetal membranes and decidua, but that MIC-1 is unlikely to be involved in the pathophysiology of preterm birth or premature rupture of membranes |
Human | ADAMTS2 | 9509 | ADAM metallopeptidase with thrombospondin type 1 motif, 2 | |
Human | FZD4 | 8322 | frizzled family receptor 4 | Absence of premature birth, low birthweight, and exposure to oxygen |
Human | BSND | 7809 | Bartter syndrome, infantile, with sensorineural deafness (Barttin) | |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Title:Association of -634G/C and 936C/T polymorphisms of the vascular endothelial growth factor with spontaneous preterm delivery.|Association:Y|Conclusion:An association was demonstrated between the VEGF 936C/T polymorphism and deliveries before 37 weeks of gestation. Results suggest that VEGF polymorphisms might be associated with a higher risk of preterm birth and in the development of perinatal complications such as enterocolitis necrotisans and acute renal failure |
Human | TSHR | 7253 | thyroid stimulating hormone receptor | Premature delivery of affected infants |
Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | amniotic fluid TNF-alpha and soluble TNF receptor concentration regulation is affected by race and preterm birth |
Human | TNFRSF1A | 7132 | tumor necrosis factor receptor superfamily, member 1A | amniotic fluid TNF-alpha and soluble TNF receptor concentration regulation is affected by race and preterm birth |
Human | TNF | 7124 | tumor necrosis factor | Title:Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes.|Association:Y|Conclusion:Tumor necrosis factor-alpha allele 2 and/or heat shock protein-70 allele 2 carriage by the first-born fetus is associated with preterm premature rupture of membranes in multifetal pregnancies. In blacks we detected a significant association between higher amniotic fluid concentrations of TNFalpha and preterm birth this may be indicative of a TNF-alpha mediated pathological process of preterm birth in blacks but not in whites Maternal carriers of the TNF allele has significantly increased risk of spontaneous preterm birth amniotic fluid TNF-alpha and soluble TNF receptor concentration regulation is affected by race and preterm birth Title:Risk of spontaneous preterm birth is associated with common proinflammatory cytokine polymorphisms.|Association:Not Found|Conclusion:Our results suggest that common genetic variants in proinflammatory cytokine genes could influence the risk for spontaneous preterm birth. Selected TNF/LTA haplotypes were associated with spontaneous preterm birth in both African-American and white subjects. Our data do not support an inflammatory etiology for SGA. Polymorphisms in the cytokine genes TNFA and IL1B may increase the risk of preterm birth, possibly by a dysregulation of the immune system in pregnancy In women with preterm labor, maternal homozygous carriage of the -863 polymorphism of the tumor necrosis factor-alpha gene may be associated with preterm delivery and adverse neonatal outcome The TNF(-488)A constituent of the AGG haplotype was also strongly associated with increased risk of spontaneous preterm birth |
Human | TLR4 | 7099 | toll-like receptor 4 | Title:Polymorphisms of genes involved in innate immunity:association with preterm delivery|Association:Not Found|Conclusion:The overall influence of the investigated polymorphisms on the development of preterm delivery seems moderate, since only the maternal IL6-174G genotype was associated with preterm birth and none of the polymorphisms were associated with intrauterine infection as the cause of preterm birth. According to the present results an allelic variation in the TLR4 receptor was associated with increased risk of premature birth |
Human | TLR2 | 7097 | toll-like receptor 2 | Title:Polymorphisms of genes involved in innate immunity:association with preterm delivery|Association:Not Found|Conclusion:The overall influence of the investigated polymorphisms on the development of preterm delivery seems moderate, since only the maternal IL6-174G genotype was associated with preterm birth and none of the polymorphisms were associated with intrauterine infection as the cause of preterm birth. Carriage of two variant TLR2 alleles potentially leads to aberrant innate immune responses, which may have contributed to very preterm birth |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | No differnce in haplotype distribution were detected for whites and African Americans for preterm birth and SGA |
Human | SLC12A1 | 6557 | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 | |
Human | CXCL5 | 6374 | chemokine (C-X-C motif) ligand 5 | ENA-78 is present in increased abundance in the amniotic cavity in response to intrauterine infection and may play a role in infection-driven preterm birth and rupture of membranes secondary to leukocyte recruitment and activation |
Human | RLN1 | 6013 | relaxin 1 | roles of the relaxin system in three potential causes of preterm birth are discussed |
Human | REN | 5972 | renin | association of the polymorphisms of the genes of the renin-angiotensin system in preterm delivery and premature rupture of membranes |
Human | RAPSN | 5913 | receptor-associated protein of the synapse | |
Human | PTH1R | 5745 | parathyroid hormone 1 receptor | |