Genes (53)
Species: human : 53 | |
Human | EFHC1 | 114327 | EF-hand domain (C-terminal) containing 1 | The combination of these polymorphisms could not be found in any control individuals, suggesting that they might be involved in genetic predisposition to migraine in this family Title:|Association:Not Found|Conclusion:Not Found | Human | C10orf2 | 56652 | chromosome 10 open reading frame 2 | | Human | GABRQ | 55879 | gamma-aminobutyric acid (GABA) A receptor, theta | Although GABRQ genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility | Human | TNFRSF21 | 27242 | tumor necrosis factor receptor superfamily, member 21 | Title:|Association:Not Found|Conclusion:Not Found | Human | DIDO1 | 11083 | death inducer-obliterator 1 | Title:A genetic association study of migraine with dopamine receptor 4, dopamine transporter and dopamine-beta-hydroxylase genes.|Association:Y|Conclusion:Our data iYdicate that MO, but Yot MA, shows sigYificaYt geYetic associatioY with DRD4. | Human | RAMP1 | 10267 | receptor (G protein-coupled) activity modifying protein 1 | RAMP1 may be strongly considered as a candidate gene for migraine | Human | SLC25A27 | 9481 | solute carrier family 25, member 27 | Title:|Association:Not Found|Conclusion:Not Found | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | Since it is unlikely that TPH polymorphism alters serotonin biosynthesis, its association with migraine may be attributed to linkage disequilibrium with a functional variant within the TPH gene or a nearby gene | Human | TNF | 7124 | tumor necrosis factor | Homozygosity for the G allele of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene associated with an increased risk of migraine without aura Title:Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine.|Association:Y|Conclusion: Association between 15 single nucleotide polymorphisms in the coding and promoter regions of lymphotoxin A and TNFalpha geneswith risk of migraine this study demonstrates an association of tumor necrosis factor-alpha (-308A) carriage with MWA, suggesting that carrying a high responder TNF-alpha-308A allele may be a genetic factor in increasing the susceptibility to develop migraine without aura | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Click here to display 10 evidence detail records. | Human | SLC6A3 | 6531 | solute carrier family 6 (neurotransmitter transporter), member 3 | findings offer no evidence for an association of the DAT(Int8) with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk functional genetic variation in the dopamine transporter does not act as a significant risk factor for migraine | Human | SCN1A | 6323 | sodium channel, voltage-gated, type I, alpha subunit | The novel T1174S missense mutation of SCN1A gene was detected segregating in a family with a heterozygous female child and in her heterozygous mother, who had an ataxic migraine syndrome similar to that of her own mother The identification of a second Familial hemiplegic migraine (FHM3) SCN1A mutation definitely established SCN1A as a migraine gene [review] | Human | RHAG | 6005 | Rh-associated glycoprotein | Title:|Association:Not Found|Conclusion:Not Found | Human | POLG | 5428 | polymerase (DNA directed), gamma | | Human | PGR | 5241 | progesterone receptor | PR genes in migraine with the 594A variant showed that individuals who possessed at least one copy of both risk alleles were 3.2 times more likely to suffer migraine Title:|Association:Not Found|Conclusion:Not Found No assoiation demonstrated between this protein and risk of migraine-associated vertigo | Human | NOTCH3 | 4854 | notch 3 | Migraine (40% of patients) Findings support the view that functional polymorphism T6746C in Notch3 gene is not involved in increasing the risk of migraine or migraine subtypes | Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | These findings substantiate the hypothesis of transitory delayed inflammation, as suggested by the animal model, and suggest the possibility of using therapeutic approaches to target NF-kappaB transcription in the treatment of migraine | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The ACE D allele confers a weak independent risk to migraine susceptibility and also appears to act in combination with the C677T variant in the MTHFR gene to confer a stronger influence on the disease C677T MTHFR polymorphism is not associated with migraine Migraine may act as mediator in the methylenetetrahydrofolate reductase-ischemic stroke pathway Title:Association of the C677T and A1298C polymorphisms in the 5 10 methylenetetrahydrofolate reductase gene in patients with migraine risk.|Association:Y|Conclusion:Not Found Title:Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.|Association:Not Found|Conclusion:We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1. The MTHFR C677T polymorphism could thus have an ambiguous role in migraine | Human | MTHFD1 | 4522 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | Title:Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.|Association:Not Found|Conclusion:We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1. | Human | MEP1A | 4224 | meprin A, alpha (PABA peptide hydrolase) | Title:|Association:Not Found|Conclusion:Not Found | Human | LTA | 4049 | lymphotoxin alpha | Association between 15 single nucleotide polymorphisms in the coding and promoter regions of LTA and TNFalpha geneswith risk of migraine | Human | LDLR | 3949 | low density lipoprotein receptor | Title:Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura.|Association:Not Found|Conclusion:Not Found The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA) | Human | KCNN3 | 3782 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | Lack of evidence that length variations of the second polyglutamine array in the N-terminus of the KCNN3 channel exert an effect in migraine susceptibility | Human | ITGB2 | 3689 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | Down-regulation of LFA-1 expression by lymphocytes could antagonize their transvascular migration, supporting the hypothesis of sterile inflammation in the dura mater during migraine attacks | Human | INSR | 3643 | insulin receptor | Title:Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.|Association:Y|Conclusion:Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. The first replication study for the reported association of the insulin receptor gene (INSR) with migraine with aura was perfoermed Title:Single-Nucleotide Polymorphism Alleles in the Insulin Receptor Gene Are Associated with Typical Migraine|Association:Y|Conclusion:Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. |
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