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Details
Link-It Detail - Disease - Migraine Disorders
Debug Stats
  • ### Total Build Time: 78 ms 63.289 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 334 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.331 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 563 bytes
  • CONCEPT_CHILDREN gt=4 ms Completed: 4 ms rowSize= 995 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.528 KB
  • CONCEPT_RELATIONSHIPS gt=47 ms Completed: 47 ms rowSize= 14.434 KB
  • CONCEPT_GENES gt=15 ms Completed: 15 ms rowSize= 42.785 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.152 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Migraine Disorders C0149931
Definition (1)

A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit.

Migraine is three times more common in women than in men. Some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision.

Many things can trigger a migraine. These include

  • Anxiety
  • Stress
  • Lack of food or sleep
  • Exposure to light
  • Hormonal changes (in women)

Doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. Now they believe the cause is related to genes that control the activity of some brain cells. Medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. For many people, treatments to relieve stress can also help.

NIH: National Institute of Neurological Disorders and Stroke

Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Headache Disorders, Primary C1565106
Children (2)
img Migraine without Aura C0338480
img Migraine with Aura C0154723
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076826img Headache Disorders, Primary C1565106
Relationships (176)

Relation Types:
diso_​to_​anat : 11
diso_​to_​chem : 49
diso_​to_​diso : 98
diso_​to_​gene : 1
diso_​to_​phen : 2
diso_​to_​phys : 15


Relationships:
none : 124
classified_​as : 10
classifies : 1
clinically_​similar : 16
isa : 11
manifestation_​of : 9
mapped_​to : 4
related_​to : 1
Page Size
Current 25
  Page 1 of 8
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO529img Complication Aspects C1171258
DISO_to_CHEM363img Serotonin Agonists C0162757
DISO_to_DISO357img Complication Aspects C1171258
DISO_to_PHEN250img genetic aspects C0017399
DISO_to_CHEM232img Tryptamines C0041248
DISO_to_PHEN156img genetic aspects C0017399
DISO_to_CHEM155img Serotonin Agonists C0162757
DISO_to_CHEM149img Analgesics C0002771
DISO_to_CHEM131img 1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl- C0075632
DISO_to_DISO127img Tension Headache C0033893
DISO_to_DISO117img Tension Headache C0033893
DISO_to_DISO114img Headache C0018681
DISO_to_CHEM110img Fructose C0016745
DISO_to_DISO104img Headache C0018681
DISO_to_ANAT98img Brain C0006104
DISO_to_CHEM97img Analgesics C0002771
DISO_to_CHEM89img Tryptamines C0041248
DISO_to_CHEM88img 1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl- C0075632
DISO_to_CHEM87img Indoles C0021242
DISO_to_ANAT85img In Blood C0005768
DISO_to_DISO80img Cerebrovascular accident C0038454
DISO_to_CHEM79img Fructose C0016745
DISO_to_DISO79img chemically induced C0007994
DISO_to_CHEM73img Anticonvulsants C0003286
DISO_to_PHYS72img GENET PREDISPOSITION C0314657
Genes (53)

Species:
human : 53
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanEFHC1114327EF-hand domain (C-terminal) containing 1
img GENERIF, Score=1000, Pubmed Id: 16378686, UMLKSK CUI: C0149931
img GAD, Score=1000, Pubmed Id: 16378686, UMLKSK CUI: C0149931
HumanC10orf256652chromosome 10 open reading frame 2
img OMIM, Score=1000, UMLKSK CUI: C0149931
HumanGABRQ55879gamma-aminobutyric acid (GABA) A receptor, theta
img GENERIF, Score=694, Pubmed Id: 19087248, UMLKSK CUI: C0149931
HumanTNFRSF2127242tumor necrosis factor receptor superfamily, member 21
img GAD, Score=1000, Pubmed Id: 16378686, UMLKSK CUI: C0149931
HumanDIDO111083death inducer-obliterator 1
img GAD, Score=1000, Pubmed Id: 12624717, UMLKSK CUI: C0149931
HumanRAMP110267receptor (G protein-coupled) activity modifying protein 1
img GENERIF, Score=1000, Pubmed Id: 18240900, UMLKSK CUI: C0149931
HumanSLC25A279481solute carrier family 25, member 27
img GAD, Score=1000, Pubmed Id: 16378686, UMLKSK CUI: C0149931
HumanTPH17166tryptophan hydroxylase 1
img GENERIF, Score=1000, Pubmed Id: 17194593, UMLKSK CUI: C0149931
HumanTNF7124tumor necrosis factor
img GENERIF, Score=1000, Pubmed Id: 14718719, UMLKSK CUI: C0149931
img OMIM, Score=1000, UMLKSK CUI: C0149931
img GAD, Score=1000, Pubmed Id: 14718719, UMLKSK CUI: C0149931
img OMIM, Score=1000, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 17635597, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 17063315, UMLKSK CUI: C0149931
HumanSLC6A46532solute carrier family 6 (neurotransmitter transporter), member 4
Click here to display 10 evidence detail records.
HumanSLC6A36531solute carrier family 6 (neurotransmitter transporter), member 3
img GENERIF, Score=1000, Pubmed Id: 17539957, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 17690944, UMLKSK CUI: C0149931
HumanSCN1A6323sodium channel, voltage-gated, type I, alpha subunit
img GENERIF, Score=901, Pubmed Id: 18021921, UMLKSK CUI: C0149931
img GENERIF, Score=660, Pubmed Id: 18451712, UMLKSK CUI: C0149931
img OMIM, Score=1000, UMLKSK CUI: C0149931
img OMIM, Score=1000, UMLKSK CUI: C0149931
HumanRHAG6005Rh-associated glycoprotein
img GAD, Score=1000, Pubmed Id: 16378686, UMLKSK CUI: C0149931
HumanPOLG5428polymerase (DNA directed), gamma
img OMIM, Score=1000, UMLKSK CUI: C0149931
HumanPGR5241progesterone receptor
img GENERIF, Score=1000, Pubmed Id: 15654614, UMLKSK CUI: C0149931
img GAD, Score=1000, Pubmed Id: 15654614, UMLKSK CUI: C0149931
img GENERIF, Score=660, Pubmed Id: 17609999, UMLKSK CUI: C0149931
HumanNOTCH34854notch 3
img OMIM, Score=1000, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 16492242, UMLKSK CUI: C0149931
HumanNOS24843nitric oxide synthase 2, inducible
img GENERIF, Score=1000, Pubmed Id: 16919057, UMLKSK CUI: C0149931
HumanMTHFR4524methylenetetrahydrofolate reductase (NAD(P)H)
img GENERIF, Score=694, Pubmed Id: 15893594, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 18957721, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 17962595, UMLKSK CUI: C0149931
img GAD, Score=666, Pubmed Id: 12654508, UMLKSK CUI: C0149931
img GAD, Score=1000, Pubmed Id: 15953655, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 17711493, UMLKSK CUI: C0149931
HumanMTHFD14522methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
img GAD, Score=1000, Pubmed Id: 15953655, UMLKSK CUI: C0149931
HumanMEP1A4224meprin A, alpha (PABA peptide hydrolase)
img GAD, Score=1000, Pubmed Id: 16378686, UMLKSK CUI: C0149931
HumanLTA4049lymphotoxin alpha
img GENERIF, Score=1000, Pubmed Id: 17635597, UMLKSK CUI: C0149931
HumanLDLR3949low density lipoprotein receptor
img GAD, Score=1000, Pubmed Id: 12873747, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 12873747, UMLKSK CUI: C0149931
HumanKCNN33782potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
img GENERIF, Score=694, Pubmed Id: 16162291, UMLKSK CUI: C0149931
HumanITGB23689integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
img GENERIF, Score=1000, Pubmed Id: 16492228, UMLKSK CUI: C0149931
HumanINSR3643insulin receptor
img GAD, Score=833, Pubmed Id: 11735220, UMLKSK CUI: C0149931
img GENERIF, Score=1000, Pubmed Id: 18455362, UMLKSK CUI: C0149931
img GAD, Score=1000, Pubmed Id: 11735220, UMLKSK CUI: C0149931
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0149931Migraine Disorders0self