GATACA

Credits

Hide Credits

Data

Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

ToppGene Links (Credits)

Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
//
// Permission is hereby granted, free of charge, to any person obtaining
// a copy of this software and associated documentation files (the
// "Software"), to deal in the Software without restriction, including
// without limitation the rights to use, copy, modify, merge, publish,
// distribute, sublicense, and/or sell copies of the Software, and to
// permit persons to whom the Software is furnished to do so, subject to
// the following conditions:
//
// The above copyright notice and this permission notice shall be
// included in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
// EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
// MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
// NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
// LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
// OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
// WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
//
// For details, see the script.aculo.us web site: http://script.aculo.us/

Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - Attention Deficit Disorder

Debug Stats

### Total Build Time: 25 ms 30.413 KB
CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 350 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 584 bytes
Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
CONCEPT_RELATIONSHIPS gt=9 ms Completed: 9 ms rowSize= 3.075 KB
CONCEPT_GENES gt=12 ms Completed: 12 ms rowSize= 25.195 KB
CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.160 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

Attention Deficit Disorder C0041671

Definition (1)

behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity; although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant; symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood.

Relationships (6)

Relation Types:

diso_to_diso : 6

Relationships:

permuted_term_of : 1

use : 5

Relation Type	Co-Occuring Concept Count	Relationship	Concept
DISO_to_DISO		permuted_term_of	Attention Deficit Disorder C0041671
DISO_to_DISO		use	Attention Deficit Disorder with Hyperactivity C1263846
DISO_to_DISO		use	Hyperactive behavior C0424295
DISO_to_DISO		use	Minimal Brain Dysfunction C1321905
DISO_to_DISO		use	hyperactive child C1691214
DISO_to_DISO		use	uncontrollable child syndrome C0597929

Genes (19)

Species:

human : 19

Species	Gene	GeneId	Gene Name	Evidence
Human	LRRK2	120892	leucine-rich repeat kinase 2	GENERIF, Score=983, Pubmed Id: 15955629, UMLKSK CUI: C0041671 This longitudinal analysis provides preliminary evidence that changes in platelet MAO activity and cholesterol, which may reflect changes in central serotonergic activity are associated with attention deficit in adolescents
Human	DISC1	27185	disrupted in schizophrenia 1	GENERIF, Score=901, Pubmed Id: 16997000, UMLKSK CUI: C0041671 chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia, and DISC1 is associated with sustained attention deficits
Human	GNE	10020	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	OMIM, Score=1000, UMLKSK CUI: C0041671 Attention deficit disorder
Human	GTF2IRD1	9569	GTF2I repeat domain containing 1	OMIM, Score=1000, UMLKSK CUI: C0041671 Attention deficit disorder
Human	TBX1	6899	T-box 1	OMIM, Score=1000, UMLKSK CUI: C0041671 Attention deficit disorder
Human	SNAP25	6616	synaptosomal-associated protein, 25kDa	GENERIF, Score=1000, Pubmed Id: 12660803, UMLKSK CUI: C0041671 trend consistent with biased transmission of the TC haplotype of SNAP-25 in all transmissions and detected a significant distortion (P=0.027) when paternal transmissions were evaluated for attention deficit disorder with hyperactivity
Human	SLC6A4	6532	solute carrier family 6 (neurotransmitter transporter), member 4	GENERIF, Score=983, Pubmed Id: 12658617, UMLKSK CUI: C0041671 Serotonin transporter promoter polymorphism associated with aggression, attention deficit, and conduct disorder in adoptee population GAD, Score=1000, Pubmed Id: 14998889, UMLKSK CUI: C0041671 Title:The serotonin transporter gene in aggressive children with and without ADHD and nonaggressive matched controls\|Association:Not Found\|Conclusion:Given the small sample size and the preliminary nature of our findings, replication is necessary.
Human	SLC6A3	6531	solute carrier family 6 (neurotransmitter transporter), member 3	GAD, Score=1000, Pubmed Id: 12172219, UMLKSK CUI: C0041671 Title:Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder.\|Association:Not Found\|Conclusion:Our findings support an association between homozygosity for the 10-repeat allele at dopamine transporter gene locus and poor response to MPH. GENERIF, Score=1000, Pubmed Id: 16082688, UMLKSK CUI: C0041671 The 3' variable number of tandem repeats and three additional promoter variants in DAT1 do not appear to be associated with attention deficit disorder with hyperactivity, or response to stimulant mediation GENERIF, Score=884, Pubmed Id: 17413453, UMLKSK CUI: C0041671 No evidence of common repeat alleles in intron 8 or 3'utr and adult attention deficit and hypersensitivity disorder GENERIF, Score=677, Pubmed Id: 12740596, UMLKSK CUI: C0041671 DAT1 VNTR polymorphism is associated with attention-deficit hyperactivity disease in a Taiwanese sample GENERIF, Score=1000, Pubmed Id: 12660802, UMLKSK CUI: C0041671 confirmed the DAT1 association with attention deficit disorder with hyperactivity
Human	PRKCG	5582	protein kinase C, gamma	OMIM, Score=1000, UMLKSK CUI: C0041671 Attention deficits
Human	GTF2I	2969	general transcription factor IIi	OMIM, Score=1000, UMLKSK CUI: C0041671 Attention deficit disorder
Human	GRIN2A	2903	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	GENERIF, Score=1000, Pubmed Id: 14966475, UMLKSK CUI: C0041671 genetic variation in GRIN2A may confer increased risk for attention deficit disorder with hyperactivity
Human	FGD1	2245	FYVE, RhoGEF and PH domain containing 1	OMIM, Score=1000, UMLKSK CUI: C0041671 Attention deficit disorder
Human	ELN	2006	elastin	OMIM, Score=1000, UMLKSK CUI: C0041671 Attention deficit disorder
Human	DRD5	1816	dopamine receptor D5	GENERIF, Score=1000, Pubmed Id: 14699430, UMLKSK CUI: C0041671 DRD5 146-bp (DRD5.146) allele and the DRD4 240-bp (DRD4.240) allele of the promoter polymorphism emerge as the two DNA variants showing a significant association in this large sample of predominantly multiplex families with attention deficit disorder GENERIF, Score=1000, Pubmed Id: 12660802, UMLKSK CUI: C0041671 susceptibility loci for attention deficit disorder with hyperactivity at DRD5
Human	DRD4	1815	dopamine receptor D4	GENERIF, Score=1000, Pubmed Id: 14699430, UMLKSK CUI: C0041671 DRD5 146-bp (DRD5.146) allele and the DRD4 240-bp (DRD4.240) allele of the promoter polymorphism emerge as the two DNA variants showing a significant association in this large sample of predominantly multiplex families with attention deficit disorder GENERIF, Score=1000, Pubmed Id: 12808433, UMLKSK CUI: C0041671 allelic heterogeneity at the DRD4 locus may also contribute to the observed association with attention deficit disorder with hyperactivity
Human	DBH	1621	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	GENERIF, Score=1000, Pubmed Id: 12660802, UMLKSK CUI: C0041671 susceptibility loci at the DBH for attention deficit disorder with hyperactivity
Human	COMT	1312	catechol-O-methyltransferase	GENERIF, Score=1000, Pubmed Id: 15654584, UMLKSK CUI: C0041671 the slower clearance of dopamine associated with the methionine variant of the COMT gene polymorphism may be disadvantageous to cognition in attention deficit disorder with hyperactivity
Human	BDNF	627	brain-derived neurotrophic factor	GENERIF, Score=983, Pubmed Id: 17216343, UMLKSK CUI: C0041671 Two exons within BDNF represent potential functional variants that may be causing the observed associations of this protein with attention deficit with hyperactivity
Human	ADRA2A	150	adrenoceptor alpha 2A	GENERIF, Score=1000, Pubmed Id: 12815749, UMLKSK CUI: C0041671 There seems to be a small effect of ADRA2A on attention deficit disorder with hyperactivity either as a susceptibility gene or as a modulator of its severity GENERIF, Score=1000, Pubmed Id: 16172611, UMLKSK CUI: C0041671 ADRA2A gene may be involved in attention deficit disorder with hyperactivity

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C0041671	Attention Deficit Disorder	0		self

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