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Details
Link-It Detail - Disease - Paraparesis, Spastic
Debug Stats
  • ### Total Build Time: 68 ms 32.149 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 401 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 382 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 184 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=10 ms Completed: 10 ms rowSize= 547 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=9 ms Completed: 9 ms rowSize= 2.792 KB
  • CONCEPT_RELATIONSHIPS gt=26 ms Completed: 26 ms rowSize= 10.291 KB
  • CONCEPT_GENES gt=12 ms Completed: 12 ms rowSize= 16.398 KB
  • CONCEPT_XREFS gt=7 ms Completed: 7 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Paraparesis, Spastic C0037771
Lower Extremity Weakness, Spastic
Definition (1)
Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.
Semantic Types (1)
Sign or Symptom (T184)
Parents (1)
img Paraparesis C0221166
Ancestral Roots
RootRoot Plus OneDepthParent
img Pathological Conditions, Signs and Symptoms C0039058img Signs and Symptoms C00370886img Paraparesis C0221166
img Nervous System Diseases C0027765img Neurologic Manifestations C00278545img Paraparesis C0221166
Relationships (23)

Relation Types:
diso_​to_​anat : 1
diso_​to_​chem : 10
diso_​to_​diso : 8
diso_​to_​phen : 2
diso_​to_​phys : 2


Relationships:
none : 15
clinically_​similar : 1
mapped_​to : 1
may_​treat : 5
permuted_​term_​of : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN34img genetic aspects C0017399
DISO_to_PHEN27img genetic aspects C0017399
DISO_to_CHEM13img Adenosine Triphosphatases C0001473
DISO_to_DISO9img Complication Aspects C1171258
DISO_to_CHEM8img Membrane Associated Proteins C0025252
DISO_to_DISO8img Alzheimer Disease C0002395
DISO_to_PHYS8img Mutation C0026882
DISO_to_CHEM7img Presenilin-1 C0299212
DISO_to_PHYS6img Mutation C0026882
DISO_to_DISO5img chemically induced C0007994
DISO_to_ANAT4img Brain C0006104
DISO_to_CHEM4img 4-Amino-3-(4-chlorophenyl)-butanoic Acid C0004609
DISO_to_CHEM4img Botulinum Toxin Type A C0006050
DISO_to_DISO4img Arachnoid Cyst C0078981
DISO_to_DISO4img Spinal Cord Diseases C0037928
DISO_to_CHEMmay_treatimg 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine C0010620
DISO_to_CHEMmay_treatimg CYPROHEPTADINE 4 MG ORAL TABLET C0976051
DISO_to_CHEMmay_treatimg CYPROHEPTADINE HCL 2MG/5ML ORAL SYRUP C1877609
DISO_to_CHEMmay_treatimg CYPROHEPTADINE HYDROCHLORIDE MONOHYDRATE C1572542
DISO_to_CHEMmay_treatimg Cyproheptadine hydrochloride C0354872
DISO_to_DISOmapped_toimg Gemignani syndrome C2931587
DISO_to_DISOpermuted_term_ofimg Lower Extremity Weakness, Spastic C0037771
DISO_to_DISOclinically_similarimg PARAPLEGIA OR PARAPARESIS C0519045
Genes (13)

Species:
human : 13
SpeciesGeneGeneIdGene NameEvidence
HumanSPG1180208spastic paraplegia 11 (autosomal recessive)
img GENERIF, Score=840, Pubmed Id: 18663179, UMLKSK CUI: C0037771
HumanFA2H79152fatty acid 2-hydroxylase
img GENERIF, Score=1000, Pubmed Id: 19068277, UMLKSK CUI: C0037771
HumanGJC257165gap junction protein, gamma 2, 47kDa
img OMIM, Score=1000, UMLKSK CUI: C0037771
HumanSPG2151324spastic paraplegia 21 (autosomal recessive, Mast syndrome)
img OMIM, Score=1000, UMLKSK CUI: C0037771
HumanSLC25A1510166solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
img OMIM, Score=882, UMLKSK CUI: C0037771
HumanSPG76687spastic paraplegia 7 (pure and complicated autosomal recessive)
img GENERIF, Score=901, Pubmed Id: 18799786, UMLKSK CUI: C0037771
HumanSPAST6683spastin
img GENERIF, Score=861, Pubmed Id: 16240363, UMLKSK CUI: C0037771
img GAD, Score=882, Pubmed Id: 11723204, UMLKSK CUI: C0037771
HumanSOX106663SRY (sex determining region Y)-box 10
img OMIM, Score=1000, UMLKSK CUI: C0037771
HumanPSEN15663presenilin 1
img GENERIF, Score=1000, Pubmed Id: 16941492, UMLKSK CUI: C0037771
img GENERIF, Score=1000, Pubmed Id: 11836371, UMLKSK CUI: C0037771
img GENERIF, Score=1000, Pubmed Id: 17507029, UMLKSK CUI: C0037771
img GENERIF, Score=812, Pubmed Id: 18637955, UMLKSK CUI: C0037771
img GENERIF, Score=1000, Pubmed Id: 17645236, UMLKSK CUI: C0037771
HumanHSPD13329heat shock 60kDa protein 1 (chaperonin)
img GENERIF, Score=901, Pubmed Id: 18458233, UMLKSK CUI: C0037771
HumanGBA2629glucosidase, beta, acid
img OMIM, Score=1000, UMLKSK CUI: C0037771
HumanEDNRB1910endothelin receptor type B
img OMIM, Score=1000, UMLKSK CUI: C0037771
HumanEDN31908endothelin 3
img OMIM, Score=1000, UMLKSK CUI: C0037771
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0037771Paraparesis, Spastic0self