Genes (102)
Species: human : 97 mouse : 5 | |
Mouse | PROP1 | 5626 | PROP paired-like homeobox 1 | We report that constitutive expression of Prop1 interferes with anterior pituitary cell differentiation and increases the susceptibility for pituitary tumors. Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility. | Mouse | ID2 | 3398 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | Here we identify a critical role for Id2 in initiation, growth, and angiogenesis of pituitary tumors from Rb(+/-) mice. | Mouse | GHRH | 2691 | growth hormone releasing hormone | Corticotropin-releasing factor (CRF) and both human pancreatic growth hormone-releasing factor (hp-GRF) and rat hypothalamic GRF (rh-GRF) stimulated ACTH release from neoplastic AtT-20 mouse pituitary tumor cells in a dose-dependent fashion, with CRF inducing a 10-fold increase and GRF a maximal increment of approximately one-half that of CRF. | Mouse | E2F3 | 1871 | E2F transcription factor 3 | E2F3 loss suppresses the development of the pituitary tumors that normally account for the death of Rb(+/-) mice. E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. To assess whether deregulated E2F activity is sufficient to induce pituitary tumors, we generated transgenic mice expressing an inducible E2F3 protein in the intermediate lobe of the pituitary gland. | Mouse | CDKN2C | 1031 | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | Whereas thymic lymphomas or pituitary tumors predominate in mice lacking p53 or Ink4c, respectively, animals lacking both genes develop many vascular tumors and also present with medulloblastomas not observed in the parental strains. Mice deficient in CKI p18 or p27 develop intermediate lobe pituitary tumors, p21 deletion facilitates such tumor growth in Rb-deficient mice, and p18 expression is low in GH-secreting pituitary adenomas (3-6). p21 and p27 gene mutations have not been detected in pituitary tumors (7,8). Whereas loss of function of other INK4 genes in mice leads to little or no tumor development, targeted deletion of p18(INK4c) causes spontaneous pituitary tumors and lymphoma late in life. | Human | MIR16-1 | 406950 | | Micro RNAs (miRs) are small noncoding RNAs, functioning as antisense regulators of other RNAs. miR-15a and miR-16-1 genes are located at chromosome 13q14, a region which is frequently deleted in pituitary tumors. miR-15a and miR-16-1 genes are located at chromosome 13q14, a region which is frequently deleted in pituitary tumors. | Human | HIST4H4 | 121504 | histone cluster 4, H4 | Prothymosin alpha (PTA) mRNA and histone H4 (H4) mRNA levels were studied in various experimental conditions that affected GH1 pituitary tumor cell proliferation. | Human | TUBA1C | 84790 | tubulin, alpha 1c | INFERRED, Score=800, UMLKSK CUI: C0032019 | Human | INHBE | 83729 | inhibin, beta E | Click here to display 8 evidence detail records. | Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | ghrelin stimulates ACTH secretion directly from human tumoural corticotrophs, as well as normal rat pituitary; marked ACTH release elicited by ghrelin in patients with Cushing's disease is due, at least in part, to its action on the pituitary tumour | Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells. P19, a group of 19,000 mol wt cytosolic proteins, with apparent isoelectric points of pI 5.9, pI 5.7, and pI 5.4, respectively, was identified in three peptide hormone-producing cell types: AtT20 mouse pituitary tumor cells, RIN-1122 rat insulinoma cells, and hamster insulinoma cells. | Human | ANGPT4 | 51378 | angiopoietin 4 | The effects of angiotensin II (AngII) and its fragment 3-8 (angiotensin IV, AngIV) on tyrosine kinase (TK) activity in estrogen-induced rat pituitary tumor homogenates were studied. | Human | RHBDD3 | 25807 | rhomboid domain containing 3 | The pituitary tumor derivation and its role in apoptosis of this gene led us to assign the acronym PTAG to this gene and its protein product. | Human | RAB18 | 22931 | RAB18, member RAS oncogene family | Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion | Human | COPS5 | 10987 | COP9 signalosome subunit 5 | In this study, we further explored the role of p27 in human pituitary tumors by measuring levels of phosphorylated p27 (P-p27), and also Jun activation domain-binding protein 1 (Jab1), which is thought to facilitate the phosphorylation and degradation of p27, in normal pituitary tissue (n = 21), pituitary adenomas (n = 75), and pituitary carcinomas (n = 10). Expression of phosphorylated p27(Kip1) protein and Jun activation domain-binding protein 1 in human pituitary tumors. | Human | GADD45G | 10912 | growth arrest and DNA-damage-inducible, gamma | a powerful growth suppressor controlling pituitary cell proliferation and the first identified gene whose expression is lost in the majority of human pituitary tumors | Human | NMU | 10874 | neuromedin U | The distributions of three novel peptides, 7B2, neuromedin B, and neuromedin U, in rat, mouse, and human pituitaries, rat hypothalamus, and 30 human pituitary tumors were investigated with immunocytochemistry. | Human | NES | 10763 | nestin | Nestin expression in adenomas cannot be viewed as a biologically relevant marker of cell proliferation and as a prognostic indicator in pituitary neoplasms | Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | Click here to display 39 evidence detail records. | Human | HGS | 9146 | hepatocyte growth factor-regulated tyrosine kinase substrate | INFERRED, Score=800, UMLKSK CUI: C0032019 | Human | AIP | 9049 | aryl hydrocarbon receptor interacting protein | present study reviews the current state of knowledge regarding the genes associated to inherited pituitary neoplasia, with a particular focus on the novel pituitary adenoma predisposing genes, CDKN1B and AIP [review] identification of a novel AIP mutation in a family with acromegaly, which further validates the role of this gene in human pituitary tumor predisposition | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | INFERRED, Score=800, UMLKSK CUI: C0032019 | Human | VEGFA | 7422 | vascular endothelial growth factor A | findings implicate altered VEGF and KDR signaling in pituitary tumorigenesis; PTTG stimulation of FGF-2 and VEGF expression in the presence of up-regulated growth factor receptors may account for angiogenic growth and progression of human pituitary tumors | Human | TRHR | 7201 | thyrotropin-releasing hormone receptor | INFERRED, Score=800, UMLKSK CUI: C0032019 | Human | TLR4 | 7099 | toll-like receptor 4 | Data suggest that, during Gram-negative bacteria-induced infections or inflammatory processes, LPS could affect pituitary tumour pathophysiology and progression in the subset of Tlr4-expressing pituitary adenomas Bacterial Endotoxin (lipopolysaccharide) Stimulates Interleukin-6 Production and Inhibits Growth of Pituitary Tumour Cells Expressing the Toll-Like Receptor 4. Tlr4 protein was detected by immunohistochemistry in a few epithelial cells in normal human anterior pituitaries and in 26 out of 67 human pituitary tumours analysed. |
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