Genes (94)
Species: human : 92 mouse : 2 | |
Mouse | CARTPT | 9607 | CART prepropeptide | Cocaine- and amphetamine-regulated transcript (CART) peptide specific binding in pheochromocytoma cells PC12. | Mouse | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | We have shown previously that the murine nm23 gene enhances pheochromocytoma PC12 cells responsiveness to NGF by accelerating cell growth arrest and neurite outgrowth. | Human | UCN3 | 114131 | urocortin 3 | Ucn and CRF receptors were all expressed in the tumor cells of pheochromocytomas, adrenocortical adenomas, and carcinomas, but its positivity was less than that in nonpathological adrenal glands, suggesting that Ucn1, Ucn3, and CRF receptors were down-regulated in these adrenal neoplasms. | Human | TUBA1C | 84790 | tubulin, alpha 1c | We report that nerve growth factor (NGF) can elevate tubulin transcript levels in cultured rat pheochromocytoma PC12 cells in a manner which correlates with its capacity to enhance neurite formation. | Human | NMNAT1 | 64802 | nicotinamide nucleotide adenylyltransferase 1 | This method was successfully applied to the determination of NMNAT activity in human placental and bull testis extracts, as well as in rat pheochromocytoma (PC12) cells. | Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Ghrelin is expressed in the medulla of human and rat adrenal glands and also expressed in human pheochromocytomas Significantly lower ghrelin mRNA expression is associated with pheochromocytomas and aldosterone-secreting adenomas | Human | GAL | 51083 | galanin/GMAP prepropeptide | point to GalR2 as a possible target for therapeuthic interventions in pheochromocytoma | Human | PRLH | 51052 | prolactin releasing hormone | PrRP has a likely role in pheochromocytomas, based on its high expression in tumor tissue | Human | KIF1B | 23095 | kinesin family member 1B | Study identified inherited loss-of-function KIF1Bbeta missense mutations in neuroblastomas and pheochromocytomas and an acquired loss-of-function mutation in a medulloblastoma Familial pheochromocytoma usually bilateral | Human | HSPH1 | 10808 | heat shock 105kDa/110kDa protein 1 | During immunohistochemical studies, we discovered that overexpression of hsp105 occurred not only in cases of colorectal and pancreatic adenocarcinoma, but also thyroid, esophageal, breast, and bladder carcinoma and islet cell tumor, gastric malignant lymphoma, pheochromocytoma, and seminoma. | Human | TXNIP | 10628 | thioredoxin interacting protein | Six metastasis suppressor genes (nm23-H1, TIMP-4, BRMS-1, TXNIP, CRSP-3 and E-Cad) were downregulated significantly in malignant compared to benign pheochromocytoma (p _lt_ 0.05, Mann-Whitney U-test). | Human | SEMA3E | 9723 | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | In vivo, expression of Sema3E in mammary adenocarcinoma cells induces the ability to form experimental lung metastasis, and in vitro, the Sema3E protein exhibits both migration and growth promoting activity on endothelial cells and pheochromocytoma cells. | Human | ENDOU | 8909 | endonuclease, polyU-specific | Increases in p11 and annexin II proteins correlate with differentiation in the PC12 pheochromocytoma. | Human | GALR2 | 8811 | galanin receptor 2 | point to GalR2 as a possible target for therapeuthic interventions in pheochromocytoma | Human | CUL2 | 8453 | cullin 2 | Title:Differences in allelic distribution of two polymorphisms in the VHL-associated gene CUL2 in pheochromocytoma patients without somatic CUL2 mutations.|Association:Not Found|Conclusion:Not Found Although our findings suggest that CUL2 does not play a major role in the pathogenesis of pheochromocytomas, it is still unknown whether epigenetic mechanisms are involved in its inactivation in VHL-associated tumors. | Human | SCG2 | 7857 | secretogranin II | Taken together, these results indicate that, in pheochromocytoma, malignancy is associated with reduced PC1, PC2, and SgII mRNA expression and decreased levels of processing products of SgII, in line with the low concentrations of EM66 that occur in malignant tumors. Expression of chromogranins A, B, and C (secretogranin II) in human adrenal medulla and in benign and malignant pheochromocytomas. Quantitative (Q)-PCR experiments indicated that SgII, PC1, and PC2 mRNAs were overexpressed in pheochromocytoma compared to non-tumoral chromaffin cells (P_lt_0.001) and in benign compared to malignant tumors (P_lt_0.01). Sixty-three neuroendocrine tumors positive for one or more immunohistochemical marker of neuroendocrine differentiation (chromogranin A, chromogranin B, synaptophysin, secretogranin II, neuron-specific enolase) were selected for the study and consisted of 34 typical carcinoids (15 pulmonary, 11 ileal, 4 gastric, and 4 rectal), 19 PETs, and 10 pheochromocytomas (4 sporadic, 3 MEN-2, 2 neurofibromatosis type 1, and 1 VHL). These data support the notion that SgII-processing products, such as EM66, could represent prognostic markers of pheochromocytomas. To demonstrate cell type-specific expression the rat SgII gene, a plasmid containing 2.6 kb of the 5;-flanking region of the SgII gene fused to the luciferase reporter gene (p2774Luc) was transfected into rat pheochromocytoma PC-12 cells, rat pituitary GH4C1 (GH) cells, human BE(2)-M17 (M17) neuroblastoma cells, and mouse fibroblast NIH/3T3 cells. | Human | PRDM2 | 7799 | PR domain containing 2, with ZNF domain | recurrent inactivation of the tumour suppressor RIZ1 suggests that this event may be a significant contributing factor to tumour development in pheochromocytomas and abdominal paragangliomas | Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | Click here to display 10 evidence detail records. | Human | VGF | 7425 | VGF nerve growth factor inducible | Northern blot analysis further demonstrated different patterns of induction of c-myc, vgf and trkA mRNA transcription in PC12 pheochromocytoma cells treated with NGF and NLP, respectively. | Human | VEGFA | 7422 | vascular endothelial growth factor A | Upregulation of vascular endothelial growth factor (VEGF) expression and its receptors may be important to the pathogenesis of pheochromocytomas in humans | Human | VBP1 | 7411 | von Hippel-Lindau binding protein 1 | Moreover, expression of the human VBP1 gene was investigated in cerebellum and in various tumours of VHL patients encompassinghaemangioblastomas, renal cell carcinomas and pheochromocytomas. | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | Although both carcinoid tumors and pheochromocytomas arise from neural crest origin, they are thought to each secrete distinctive monoamines; carcinoid tumors, which contain tryptophan hydroxylase, secrete serotonin, and pheochromocytomas, which contain tyrosine hydroxylase, may secrete dopamine (DA), norepinephrine (NE), or epinephrine (E). | Human | TP53 | 7157 | tumor protein p53 | the p53 gene does not appear to play a major role in pheochromocytoma tumorigenesis | Human | TMPO | 7112 | thymopoietin | Thymopoietin interacts at the alpha-bungarotoxin site of and induces process formation in PC12 pheochromocytoma cells. Thymopoietin, a polypeptide isolated from thymus and involved in immune regulation, potently inhibited [125I]alpha-bungarotoxin binding in both pheochromocytoma (PC12) cells in culture (IC50 of 3.9 nM) and in PC12 cell membranes (IC50 of 2.2 nM). | Human | SYP | 6855 | synaptophysin | Click here to display 11 evidence detail records. |
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