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Details
Link-It Detail - Disease - Pheochromocytoma
Debug Stats
  • ### Total Build Time: 338 ms 58.038 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 330 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 878 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 549 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=3 ms Completed: 3 ms rowSize= 1.498 KB
  • CONCEPT_RELATIONSHIPS gt=302 ms Completed: 302 ms rowSize= 16.958 KB
  • CONCEPT_GENES gt=23 ms Completed: 23 ms rowSize= 36.498 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.150 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Pheochromocytoma C0031511
Definition (1)
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Semantic Types (1)
Neoplastic Process (T191)
Parents (1)
img Paraganglioma C0030421
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276527img Paraganglioma C0030421
Relationships (153)

Relation Types:
diso_​to_​anat : 24
diso_​to_​chem : 47
diso_​to_​diso : 70
diso_​to_​gene : 4
diso_​to_​phen : 4
diso_​to_​phys : 4


Relationships:
none : 69
clinically_​similar : 8
gene_​associated_​with_​disease : 4
gene_​product_​malfunction_​associated_​with_​disease : 3
is_​abnormal_​cell_​of_​disease : 5
is_​associated_​anatomic_​site_​of : 3
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 3
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 1
is_​not_​normal_​tissue_​origin_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 5
isa : 6
may_​be_​finding_​of_​disease : 9
may_​diagnose : 7
may_​treat : 21
permuted_​term_​of : 1
related_​to : 3
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO1034img Adrenal Gland Neoplasms C0001624
DISO_to_DISO858img Adrenal Gland Neoplasms C0001624
DISO_to_DISO310img Complication Aspects C1171258
DISO_to_PHEN234img genetic aspects C0017399
DISO_to_DISO231img Complication Aspects C1171258
DISO_to_PHEN196img genetic aspects C0017399
DISO_to_DISO131img Paraganglioma C0030421
DISO_to_DISO75img Hypertension C0020538
DISO_to_ANAT66img In Blood C0005768
DISO_to_DISO59img Hypertension C0020538
DISO_to_DISO57img Paraganglioma C0030421
DISO_to_CHEM52img Catecholamines C0007412
DISO_to_ANAT49img In Blood C0005768
DISO_to_CHEM47img ((3-Iodophenyl)Methyl)Guanidine C0047506
DISO_to_DISO42img Multiple Endocrine Neoplasia Type 2a C0025268
DISO_to_CHEM40img Succinate Dehydrogenase C0038615
DISO_to_DISO40img Von Hippel-Lindau Syndrome C0019562
DISO_to_CHEM36img Metanephrine C0025562
DISO_to_CHEM32img BIOCHEM TUMOR MARKERS C0041366
DISO_to_CHEM31img ((3-Iodophenyl)Methyl)Guanidine C0047506
DISO_to_DISO31img COMPL NEOPL PREGN C0032966
DISO_to_PHEN31img Process of secretion C0036536
DISO_to_PHYS31img Germ-Line Mutation C0206530
DISO_to_CHEM30img Catecholamines C0007412
DISO_to_DISO29img MULTIPLE PRIMARY NEOPL C0027663
Genes (94)

Species:
human : 92
mouse : 2
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
MouseCARTPT9607CART prepropeptide
img NCI, Score=801, Pubmed Id: 17292884, UMLKSK CUI: C0031511
MouseNME14830NME/NM23 nucleoside diphosphate kinase 1
img NCI, Score=801, Pubmed Id: 11423907, UMLKSK CUI: C0031511
HumanUCN3114131urocortin 3
img NCI, Score=801, Pubmed Id: 15914529, UMLKSK CUI: C0031511
HumanTUBA1C84790tubulin, alpha 1c
img NCI, Score=801, Pubmed Id: 3683739, UMLKSK CUI: C0031511
HumanNMNAT164802nicotinamide nucleotide adenylyltransferase 1
img NCI, Score=801, Pubmed Id: 8852039, UMLKSK CUI: C0031511
HumanGHRL51738ghrelin/obestatin prepropeptide
img GENERIF, Score=861, Pubmed Id: 17952858, UMLKSK CUI: C0031511
img GENERIF, Score=1000, Pubmed Id: 18246525, UMLKSK CUI: C0031511
HumanGAL51083galanin/GMAP prepropeptide
img GENERIF, Score=1000, Pubmed Id: 18272487, UMLKSK CUI: C0031511
HumanPRLH51052prolactin releasing hormone
img GENERIF, Score=1000, Pubmed Id: 12126742, UMLKSK CUI: C0031511
HumanKIF1B23095kinesin family member 1B
img GENERIF, Score=1000, Pubmed Id: 18334619, UMLKSK CUI: C0031511
img OMIM, Score=833, UMLKSK CUI: C0031511
HumanHSPH110808heat shock 105kDa/110kDa protein 1
img NCI, Score=801, Pubmed Id: 14534695, UMLKSK CUI: C0031511
HumanTXNIP10628thioredoxin interacting protein
img NCI, Score=801, Pubmed Id: 15523699, UMLKSK CUI: C0031511
HumanSEMA3E9723sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
img NCI, Score=801, Pubmed Id: 16024618, UMLKSK CUI: C0031511
HumanENDOU8909endonuclease, polyU-specific
img NCI, Score=801, Pubmed Id: 1829356, UMLKSK CUI: C0031511
HumanGALR28811galanin receptor 2
img GENERIF, Score=1000, Pubmed Id: 18272487, UMLKSK CUI: C0031511
HumanCUL28453cullin 2
img GAD, Score=1000, Pubmed Id: 10487688, UMLKSK CUI: C0031511
img NCI, Score=801, Pubmed Id: 10487688, UMLKSK CUI: C0031511
HumanSCG27857secretogranin II
img NCI, Score=801, Pubmed Id: 17102121, UMLKSK CUI: C0031511
img NCI, Score=801, Pubmed Id: 15601318, UMLKSK CUI: C0031511
img NCI, Score=801, Pubmed Id: 17102121, UMLKSK CUI: C0031511
img NCI, Score=801, Pubmed Id: 15371954, UMLKSK CUI: C0031511
img NCI, Score=801, Pubmed Id: 17102121, UMLKSK CUI: C0031511
img NCI, Score=801, Pubmed Id: 8756552, UMLKSK CUI: C0031511
HumanPRDM27799PR domain containing 2, with ZNF domain
img GENERIF, Score=1000, Pubmed Id: 15809732, UMLKSK CUI: C0031511
HumanVHL7428von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Click here to display 10 evidence detail records.
HumanVGF7425VGF nerve growth factor inducible
img NCI, Score=801, Pubmed Id: 9858363, UMLKSK CUI: C0031511
HumanVEGFA7422vascular endothelial growth factor A
img GENERIF, Score=1000, Pubmed Id: 14659975, UMLKSK CUI: C0031511
HumanVBP17411von Hippel-Lindau binding protein 1
img NCI, Score=801, Pubmed Id: 9931330, UMLKSK CUI: C0031511
HumanTPH17166tryptophan hydroxylase 1
img NCI, Score=801, Pubmed Id: 3974452, UMLKSK CUI: C0031511
HumanTP537157tumor protein p53
img GENERIF, Score=694, Pubmed Id: 18223555, UMLKSK CUI: C0031511
HumanTMPO7112thymopoietin
img NCI, Score=801, Pubmed Id: 2089274, UMLKSK CUI: C0031511
img NCI, Score=801, Pubmed Id: 2089274, UMLKSK CUI: C0031511
HumanSYP6855synaptophysin
Click here to display 11 evidence detail records.
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0031511Pheochromocytoma0self