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Genes (10)
Species: human : 10 | |
Human | FOXP3 | 50943 | forkhead box P3 | Fox3p expression is inherent feature of the function of type 1 regulatory T cells specific for desmoglein-3, the autoantigen of pemphigus vulgaris | Human | TNF | 7124 | tumor necrosis factor | Pemphigus vulgaris patient IgG works together with tumor necrosis factor-alpha and FAS-L in experimental cell cultures to induce acantholysis via basal cell shrinkage | Human | TAP2 | 6891 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | Two Pemphigus vulgaris (PV) TAP2 risk alleles were identified (TAP2*C and TAP2*D) implying that TAP2 genes are involved in susceptibility to development of PV | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | This study demonstrated that proteinase expression, particularly of MMP-9, is modulated by pemphigus vulgaris (PV) serum and associated with PV acantholysis | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | data suggest that IL-6 and TNF-alpha may be involved in maintaining immunological disturbances in remission stage of pemphigus vulgaris | Human | HLA-DRB1 | 3123 | | Genetic predisposition for pemphigus vulgaris seems to be one of the etiopathogenetic factor of this disease HLA-DRbeta1*0402 tetramers provide a highly specific approach to monitor ex vivo the T cellular autoimmune response against desmoglein-3 in patients with pemphigus vulgaris Title:Association between pemphigus vulgaris and human leukocyte antigen in Han nation of northeast China.|Association:Not Found|Conclusion:PV significantly relates with HLA in PV patients of Han nation of northeast China. Title:HLA Haplotypes and Class II Molecular Alleles in Argentinian Patients with Pemphigus Vulgaris|Association:Not Found|Conclusion:In patients with the haplotype DRb1* 0402/DQb1* 0302 the affectation of 10%-30% of the corporal surface prevailed (ACS). In patients with DRb1* 1401/DRQb1* 0503, involvement of <10% of the ACS prevailed. DRB1*0402 without DQB1*0302 is the most relevant HLA-DRB1 allele responsible for the pathogenesis of pemphigus in Venezuelan patients with pemphigus vulgaris | Human | HLA-DQB1 | 3119 | | Title:HLA Haplotypes and Class II Molecular Alleles in Argentinian Patients with Pemphigus Vulgaris|Association:Not Found|Conclusion:In patients with the haplotype DRb1* 0402/DQb1* 0302 the affectation of 10%-30% of the corporal surface prevailed (ACS). In patients with DRb1* 1401/DRQb1* 0503, involvement of <10% of the ACS prevailed. DRB1*0402 without DQB1*0302 is the most relevant HLA-DRB1 allele responsible for the pathogenesis of pemphigus in Venezuelan patients with pemphigus vulgaris Title:Association between pemphigus vulgaris and human leukocyte antigen in Han nation of northeast China.|Association:Not Found|Conclusion:PV significantly relates with HLA in PV patients of Han nation of northeast China. | Human | HLA-DQA1 | 3117 | | HLA-DQA1 antigen polymorphism is shown in patients with pemphigus vulgaris | Human | DSG3 | 1830 | desmoglein 3 | pemphigus vulgaris-IgG-dependent uPA activation is not related to anti-Dsg3 antibody activity analysis of desmoglein 3 ectodomain in pemphigus vulgaris Our method for the isolation of Dsg3-specific B cells will allow the systematic analysis of immunoglobulin gene usage in pemphigus vulgaris patients, which may elucidate the mechanism of immunopathogenesis The appearance of DSG3-reactive Th2 cells is constant at different stages of pemphigus vulgaris (PV), while DSG3-reactive Th1 cells are detected at a significantly higher frequency in chronic active PV The T cellular autoimmune response against immunodominant peptides of Dsg3 in patients with pemphigus vulgaris is monitored with highly specific HLA-DRbeta1*0402 tetramers Abs to Dsg 3 contribute to Pemphigus vulgaris by direct inhibition of Dsg transinteraction Pemphigus vulgaris (PV) IgG-induced Dsg3 internalization is mediated through a clathrin- and dynamin-independent pathway and Dsg3 endocytosis is tightly coupled to the pathogenic activity of PV IgG Reduction of Dsg3 might be relevant to blister formation in pemphigus vulgaris Autoantibody from pemphigus vulgaris sera react with non-conformational epitopes of desmoglein 3 Data show that both pemphigus foliaceus-IgG containing Dsg 1- but not Dsg 3-specific antibodies and pemphigus vulgaris-IgG with antibodies to Dsg 1 and Dsg 3 were effective in causing epidermal splitting in human skin and keratinocyte dissociation proteolytic processing of Dsg3 can lead to depletion of Dsg3 from the cell in pemphigus vulgaris | Human | FASLG | 356 | Fas ligand (TNF superfamily, member 6) | Pemphigus vulgaris patient IgG works together with Fas-L and tumor necrosis factor-alpha in experimental cell cultures to induce acantholysis via basal cell shrinkage |
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