Debug Stats | ### Total Build Time: 28 ms 41.523 KB CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 336 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 308 bytes- Skipping details on:
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Genes (14)
Species: human : 14 | |
Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | Expresson is reduced in treatment with methotrexate in bullous pemphigoid | Human | SELL | 6402 | selectin L | Data show that in bullous pemphigoid, expression of L selectins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis | Human | SELE | 6401 | selectin E | Data show that in bullous pemphigoid, expression of E selectins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis | Human | MIF | 4282 | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | MIF might be involved in the pathogenesis of bullous pemphigoid | Human | ITGB4 | 3691 | integrin, beta 4 | Data show that in bullous pemphigoid, expression of beta4 integrin was irregular and was detected mainly in dermal part of the blister | Human | ITGB3 | 3690 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Data show that in bullous pemphigoid, beta3 integrins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis | Human | ITGB1 | 3688 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Data show that in bullous pemphigoid, expression of beta1 was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis | Human | ITGA6 | 3655 | integrin, alpha 6 | A peptide is identified within the extracellular domain of integrin alpha 6 molecule, to which antibodies in the sera from patients with oral pemphigoid (OP) bind, and which may play an important role in the pathogenesis of OP | Human | HLA-DRB1 | 3123 | | Title:HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China.|Association:Not Found|Conclusion:This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP. | Human | HLA-DQB1 | 3119 | | Title:HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China.|Association:Not Found|Conclusion:This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP. Title:HLA-DQB1 alleles in Italian patients with mucous membrane pemphigoid predominantly affecting the oral cavity|Association:Y|Conclusion:Our data suggest that Italian patients with MMP lesions predominantly affecting the oral cavity present the same genetic predisposition linked to HLA-DQB1*0301 previously reported mainly in patients with OCP. | Human | HLA-DQA1 | 3117 | | Title:HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China.|Association:Y|Conclusion:This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP. | Human | FCGR3A | 2214 | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | Title:Relevance of the low-affinity type of the Fcgamma-receptor IIIa-polymorphism in bullous pemphigoid|Association:Not Found|Conclusion:Not Found FcgammaRIIIa (158 F/V) polymorphism may modulate susceptibility to acquire bullous pemphigoid | Human | COL17A1 | 1308 | collagen, type XVII, alpha 1 | IgE autoantibodies to BP180 and BP230 are detected at high frequencies in bullous pemphigoid bullous pemphigoid sera reacted with at least an additional antigenic site other than the NC16A, within the extracellular (37%) and intracellular (28%) domains of BP180 expression of BP180 is related to clinical severity of bullous pemphigoid Bullous Pemphigoid disease severity and activity correlated with levels of IgG against the BP180-NC16A domain, but also against a COOH-terminal epitope of BP180 genetic variation in COL17A1 shows no association with susceptibility to bullous pemphigoid Epitooe mapping of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoid | Human | DST | 667 | dystonin | antibodies against BP230 can elicit the clinical and immunopathological features of Bullous pemphigoid in neonatal mice keratinocyte responsive element 3 functions as a position-, copy number-, and orientation-dependent cis-element contributing to tissue-specific regulation of the 230-kDa bullous pemphigoid antigen gene |
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