Debug Stats | ### Total Build Time: 89 ms 44.521 KB CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 324 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 460 bytes- Skipping details on:
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CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 557 bytesCONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 1,000 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.506 KBCONCEPT_RELATIONSHIPS gt=54 ms Completed: 54 ms rowSize= 15.183 KBCONCEPT_GENES gt=22 ms Completed: 22 ms rowSize= 24.188 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.147 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
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Genes (102)
Species: human : 102 | |
Human | UCN3 | 114131 | urocortin 3 | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | TUBA1C | 84790 | tubulin, alpha 1c | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | NMNAT1 | 64802 | nicotinamide nucleotide adenylyltransferase 1 | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | PTBP2 | 58155 | polypyrimidine tract binding protein 2 | In this paper we examine the specific cellular distribution of PTB expression in normal brain (n = 2) and tumors of various types (low-grade astrocytoma, n = 2; anaplastic astrocytoma, n = 2; glioblastoma, n = 4; medulloblastoma, n = 4; central neurocytoma, n = 2; dysplastic gangliocytoma, n = 1; ganglioglioma, n = 1; paraganglioma, n = 1). | Human | SDHAF2 | 54949 | succinate dehydrogenase complex assembly factor 2 | Germline mutations in any of the following genes: SDHD, SDHC, SDHB, PGL2 or other unknown genes, can cause paragangliomas (PGLs). | Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | GAL | 51083 | galanin/GMAP prepropeptide | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | PRLH | 51052 | prolactin releasing hormone | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | KIF1B | 23095 | kinesin family member 1B | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | HSPH1 | 10808 | heat shock 105kDa/110kDa protein 1 | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | TXNIP | 10628 | thioredoxin interacting protein | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | SEMA3E | 9723 | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | ENDOU | 8909 | endonuclease, polyU-specific | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | GALR2 | 8811 | galanin receptor 2 | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | CUL2 | 8453 | cullin 2 | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | SCG2 | 7857 | secretogranin II | In parasympathetic paragangliomas both chromogranin B and secretogranin II immunoreactivity was demonstrated in the majority of chief cells of all 14 tumors investigated. In sympathetic paragangliomas chromogranin A was found in 12/12 and chromogranin B in 11/12 tumors in almost all chief cells (the remaining tumor was focally chromogranin B positive), whereas secretogranin II was immunolocalized in the majority of chief cells in 5/12, in a focal distribution in 3/12, and only in a few scattered tumor cells in 3/12 cases. Tumour tissues from 25 argyrophil gastric carcinoids, 18 gastrin and 5 somatostatin-producing tumours, 4 ;gangliocytic paragangliomas;, 49 classical argentaffin and 2 L cell appendiceal carcinoids, 27 classical ileal carcinoids, 17 rectal carcinoids, and 5 poorly differentiated neuroendocrine tumours of the stomach and rectum were immunostained with antibodies against chromogranin A, chromogranin B, and secretogranin II. | Human | PRDM2 | 7799 | PR domain containing 2, with ZNF domain | recurrent inactivation of the tumour suppressor RIZ1 suggests that this event may be a significant contributing factor to tumour development in pheochromocytomas and abdominal paragangliomas | Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | Germline mutation on the VHL gene was present in patients with pheochromocytoma or functional paraganglioma analysis of Von Hippel-Lindau mutations in Korean patients with von Hippel-Lindau disease, pheochromocytomas and paragangliomas | Human | VGF | 7425 | VGF nerve growth factor inducible | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | VEGFA | 7422 | vascular endothelial growth factor A | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | VBP1 | 7411 | von Hippel-Lindau binding protein 1 | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | TP53 | 7157 | tumor protein p53 | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | TMPO | 7112 | thymopoietin | INFERRED, Score=800, UMLKSK CUI: C0030421 | Human | TFF1 | 7031 | trefoil factor 1 | We examined TFF-1 expression using immunohistochemistry on formalin-fixed, paraffin-embedded sections of 49 gastrointestinal carcinoids; 15 pancreatic islet cell tumors; 21 paragangliomas; 8 medullary thyroid carcinomas; 7 small cell carcinomas of the uterine cervix; 4 prostate, 4 bladder, and 6 Merkel cell (primary cutaneous neuroendocrine) carcinomas; and 1 renal carcinoma No gastrointestinal carcinoid tumor, pancreatic islet cell tumor, paraganglioma, or Merkel cell carcinoma expressed TFF-1. |
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