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Genes (228)
Species: human : 223 mouse : 5 | |
Mouse | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | Functional analysis shows that blocking of both Stat3 and NF-kappaB together induces programmed cell death in murine pancreatic tumor cells. | Mouse | SERPINE2 | 5270 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | SERPINE2 (protease nexin I) promotes extracellular matrix production and local invasion of pancreatic tumors in vivo. | Mouse | KDR | 3791 | kinase insert domain receptor (a type III receptor tyrosine kinase) | CONCLUSION: A recombinant adenovirus encoding soluble Flk-1 inhibited pancreatic tumor growth in mice. | Mouse | CCKBR | 887 | cholecystokinin B receptor | INTRODUCTION: We demonstrated previously, in two different rodent models of pancreatic cancer, that the gastrin receptor is present on malignant pancreatic tumors in spite of the fact that the normal adult rat and mouse pancreas does not express gastrin receptors. CONCLUSION: In both female and male transgenic mice, the expression of the gastrin receptor in the exocrine pancreas is associated with a significant increase in pancreas weight, but it does not appear to promote the development of spontaneous pancreatic tumors. | Mouse | BIK | 638 | BCL2-interacting killer (apoptosis-inducing) | Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | EXPERIMENTAL DESIGN: Total RNA from 16 pancreatic tumors, 10 chronic pancreatitis tissues, 7 normal pancreas tissues, and 15 pancreatic tumor cell lines were analyzed by reverse transcription-PCR with primers specific for MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7 genes and by RNA slot blot analyses. | Human | MAFA | 389692 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | GATA5 | 140628 | GATA binding protein 5 | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | PTPMT1 | 114971 | protein tyrosine phosphatase, mitochondrial 1 | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | NKX6-2 | 84504 | | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | REG4 | 83998 | regenerating islet-derived family, member 4 | These data suggest that Reg IV is expressed by gastrointestinal and pancreatic tumours, including adenocarcinomas and carcinoid tumours, and that Reg IV is associated with intestinal and neuroendocrine differentiation of the stomach and gastric carcinoma. These data suggest that Reg IV is expressed by gastrointestinal and pancreatic tumours, including adenocarcinomas and carcinoid tumours, and that Reg IV is associated with intestinal and neuroendocrine differentiation of the stomach and gastric carcinoma. | Human | INHBE | 83729 | inhibin, beta E | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | VTCN1 | 79679 | V-set domain containing T cell activation inhibitor 1 | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | HHIP | 64399 | hedgehog interacting protein | Aberrant methylation of the Human Hedgehog interacting protein is associated with pancreatic neoplasms Aberrant Methylation of the Human Hedgehog Interacting Protein (HHIP) Gene in Pancreatic Neoplasms. These results indicate in some pancreatic adenocarcinomas that HHIP is epigenetically inactivated by promoter methylation, and its silencing could contribute to the increased Hedgehog signaling observed in pancreatic neoplasms. | Human | MUC3B | 57876 | mucin 3B, cell surface associated | In contrast, MUC2 mRNA was expressed at only low levels and MUC3 was not detected in the pancreatic tumor cell lines. EXPERIMENTAL DESIGN: Total RNA from 16 pancreatic tumors, 10 chronic pancreatitis tissues, 7 normal pancreas tissues, and 15 pancreatic tumor cell lines were analyzed by reverse transcription-PCR with primers specific for MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7 genes and by RNA slot blot analyses. We examined the steady-state expression levels of mRNA for the MUC1, MUC2, MUC3 and MUC4 gene products in 12 pancreatic tumor cell lines, 6 colon tumor cell lines, and one ileocecal tumor cell line. | Human | GOPC | 57120 | golgi-associated PDZ and coiled-coil motif containing | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | ANLN | 54443 | anillin, actin binding protein | Anillin mRNA expression was analyzed during tumor progression in breast, ovarian, kidney, colorectal, hepatic, lung, endometrial, and pancreatic tumors and in all tissues there was progressive increase in anillin mRNA expression from normal to benign to malignant to metastatic disease. | Human | WWOX | 51741 | WW domain containing oxidoreductase | the WWOX gene may play an important role in pancreatic tumor development | Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | NOX4 | 50507 | NADPH oxidase 4 | A novel signaling pathway, in which NADPH oxidase activation results in inhibition of protein tyrosine phosphatases, leading to enhanced and sustained phosphorylation of kinases (JAK2), and suppression of apoptosis is suggested in pancreatic neoplasms | Human | LSM1 | 27257 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) | Click here to display 6 evidence detail records. | Human | PLCB1 | 23236 | phospholipase C, beta 1 (phosphoinositide-specific) | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | TXNIP | 10628 | thioredoxin interacting protein | INFERRED, Score=800, UMLKSK CUI: C0030297 | Human | MSLN | 10232 | mesothelin | Clinical trials are ongoing using immunotoxins to target mesothelin, and patients immunized with allogeneic pancreatic tumor cell lines have shown immune responses to previously defined mesothelin epitopes. Quantitative detection of mesothelin mRNA in PPJ may have potential diagnostic implications for pancreatic tumors. | Human | ABCC5 | 10057 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | These data suggest that MRP3 and MRP5 are involved in drug resistance of pancreatic tumors and that quantitative analysis of their expression may contribute to predict the benefit of chemotherapy in patients with pancreatic cancer. |
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