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Details
Link-It Detail - Disease - Paget Disease, Extramammary
Debug Stats
  • ### Total Build Time: 46 ms 35.714 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 408 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 809 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 1,009 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 2.790 KB
  • CONCEPT_RELATIONSHIPS gt=31 ms Completed: 31 ms rowSize= 13.940 KB
  • CONCEPT_GENES gt=8 ms Completed: 8 ms rowSize= 15.431 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.161 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Paget Disease, Extramammary C0030186
Paget Disease Extramammary
Definition (1)
A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)
Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Adenocarcinoma C0001418
img Neoplasms, Ductal, Lobular, and Medullary C0206768
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276526img Adenocarcinoma C0001418
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Neoplasms, Ductal, Lobular, and Medullary C0206768
Relationships (71)

Relation Types:
diso_​to_​anat : 14
diso_​to_​chem : 31
diso_​to_​diso : 26


Relationships:
none : 22
is_​abnormal_​cell_​of_​disease : 6
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 1
is_​normal_​tissue_​origin_​of_​disease : 1
is_​not_​abnormal_​cell_​of_​disease : 4
is_​not_​finding_​of_​disease : 1
isa : 5
may_​treat : 28
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO88img Cutaneous tumor C0037286
DISO_to_DISO53img NEOPL VULVAR C0042995
DISO_to_DISO46img Cutaneous tumor C0037286
DISO_to_DISO43img NEOPL VULVAR C0042995
DISO_to_DISO40img GENITAL NEOPL MALE C0017417
DISO_to_ANAT29img Scrotum C0036471
DISO_to_DISO29img GENITAL NEOPL MALE C0017417
DISO_to_CHEM22img Aminoquinolines C0002588
DISO_to_CHEM21img Antineoplastic Agents C0003392
DISO_to_DISO21img Anus Neoplasms C0003463
DISO_to_ANAT18img Scrotum C0036471
DISO_to_DISO17img Adenocarcinoma C0001418
DISO_to_DISO15img Complication Aspects C1171258
DISO_to_DISO15img NEOPL PENILE C0030849
DISO_to_DISO14img Anus Neoplasms C0003463
DISO_to_DISO14img Breast Neoplasms C1458155
DISO_to_DISO13img MULTIPLE PRIMARY NEOPL C0027663
DISO_to_DISO12img NEOPL PENILE C0030849
DISO_to_DISO12img Paget's Disease, Mammary C0030185
DISO_to_CHEM11img BIOCHEM TUMOR MARKERS C0041366
DISO_to_DISO11img Breast Neoplasms C1458155
DISO_to_DISO11img LOCAL NEOPL RECURRENCE C0027643
DISO_to_ANATis_abnormal_cell_of_diseaseimg Adenocarcinoma Cell C1510779
DISO_to_ANATis_abnormal_cell_of_diseaseimg Carcinoma Cell C1518174
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
Genes (11)

Species:
human : 11
SpeciesGeneGeneIdGene NameEvidence
HumanLITAF9516lipopolysaccharide-induced TNF factor
img NCI, Score=801, Pubmed Id: 15197774, UMLKSK CUI: C0030186
HumanEBAG99166estrogen receptor binding site associated, antigen, 9
img NCI, Score=801, Pubmed Id: 11378331, UMLKSK CUI: C0030186
img NCI, Score=801, Pubmed Id: 11378331, UMLKSK CUI: C0030186
img NCI, Score=801, Pubmed Id: 11378331, UMLKSK CUI: C0030186
img NCI, Score=801, Pubmed Id: 12653716, UMLKSK CUI: C0030186
img NCI, Score=801, Pubmed Id: 11378331, UMLKSK CUI: C0030186
HumanSDC16382syndecan 1
img NCI, Score=801, Pubmed Id: 14690462, UMLKSK CUI: C0030186
HumanRELA5970v-rel avian reticuloendotheliosis viral oncogene homolog A
img GENERIF, Score=1000, Pubmed Id: 17207971, UMLKSK CUI: C0030186
HumanPTK25747protein tyrosine kinase 2
img GENERIF, Score=1000, Pubmed Id: 18210145, UMLKSK CUI: C0030186
HumanMSN4478moesin
img NCI, Score=801, Pubmed Id: 9696288, UMLKSK CUI: C0030186
img NCI, Score=801, Pubmed Id: 9696288, UMLKSK CUI: C0030186
HumanMMP194327matrix metallopeptidase 19
img GENERIF, Score=923, Pubmed Id: 15239678, UMLKSK CUI: C0030186
HumanMMP74316matrix metallopeptidase 7 (matrilysin, uterine)
img GENERIF, Score=923, Pubmed Id: 15239678, UMLKSK CUI: C0030186
HumanKRT193880keratin 19
img GENERIF, Score=884, Pubmed Id: 16681689, UMLKSK CUI: C0030186
HumanMAPK141432mitogen-activated protein kinase 14
img GENERIF, Score=1000, Pubmed Id: 17207971, UMLKSK CUI: C0030186
HumanCCND1595cyclin D1
img GENERIF, Score=1000, Pubmed Id: 17207971, UMLKSK CUI: C0030186
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0030186Paget Disease, Extramammary0self