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Genes (390)
Species: human : 382 mouse : 8 | |
Mouse | SP7 | 121340 | Sp7 transcription factor | Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma. | Mouse | TBX18 | 9096 | T-box 18 | Allelic imbalance at intragenic markers of Tbx18 is a hallmark of murine osteosarcoma. | Mouse | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | Previous data have demonstrated that human osteosarcoma biopsies express RANKL as well as OPG, and functional RANK is expressed in a murine osteosarcoma cell line. | Mouse | EZR | 7430 | ezrin | The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. We have previously showed that ezrin expression is necessary for metastatic behavior in a murine model of osteosarcoma (K7M2). Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. In a mouse model of osteosarcoma, a highly metastatic pediatric cancer, we found ezrin to be necessary for metastasis. | Mouse | LOX | 4015 | lysyl oxidase | Molecular events that contribute to lysyl oxidase enzyme activity and insoluble collagen accumulation in osteosarcoma cell clones. | Mouse | IGFBP7 | 3490 | insulin-like growth factor binding protein 7 | Addition of recombinant mac25 protein (10-7 M) into the culture medium induced significant suppression of the growth of human cervical carcinoma cells (HeLa) and murine embryonic carcinoma cells (P19), as well as osteosarcoma cells (Saos-2). | Mouse | CDKN2C | 1031 | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | Mice lacking both p18 and p53 develop several tumors not reported in either single null genotype, including hepatocellular carcinoma, testicular choriocarcinoma, hemangiosarcoma, leiomyosarcoma, fibrosarcoma, and osteosarcoma. | Mouse | BMP4 | 652 | bone morphogenetic protein 4 | These experimental results suggest that BMP-4 is one of the molecules responsible for the transfilter bone induction by vital Dunn osteosarcoma cells reported by Heiple and for the ectopic bone induction after implantation of devitalized, freeze-dried Dunn osteosarcoma tissue described originally by Amitani. | Human | LOC100507436 | 100507436 | | Our data showed that MICA is prevalently expressed in osteosarcoma both in mRNA and protein level MICA is widely expressed in osteosarcoma | Human | XAGE1B | 653220 | X antigen family, member 1B | INFERRED, Score=800, UMLKSK CUI: C0029463 | Human | BPY2C | 442868 | basic charge, Y-linked, 2C | INFERRED, Score=800, UMLKSK CUI: C0029463 | Human | ADAMTS19 | 171019 | ADAM metallopeptidase with thrombospondin type 1 motif, 19 | High levels of ADAMTSs transcripts were also observed in some tumor biopsies and cells lines, including osteosarcomas (ADAMTS19), melanoma and colon carcinoma cells (ADAMTS13). | Human | ZNF384 | 171017 | zinc finger protein 384 | Parathyroid hormone increased NP/NMP4 binding to both poly(dT) elements and decreased COL1A1 mRNA in the osteosarcoma cells. | Human | HIST4H4 | 121504 | histone cluster 4, H4 | Cell density-induced growth inhibition of osteosarcoma cells (ROS 17/2.8) results in the shutdown of proliferation-specific histone H4 and H2B genes and the concomitant up-regulation of several osteoblast-related genes. In the present investigation the effects of GN on bone formation were studied in the rat osteosarcoma (ROS) 17/2.8 cell line and normal diploid rat osteoblasts (ROB) in vitro and the femur of rats treated in vivo, measuring mRNA levels for two osteoblast parameters, type I collagen, a marker of matrix formation, and osteocalcin, a bone specific protein and also histone H4, a marker of cell proliferation. | Human | SP7 | 121340 | Sp7 transcription factor | The Sp7 mRNA was expressed in human foetal osteoblasts and craniofacial osteoblasts, chondrocytes and the osteosarcoma cell lines HOS and MG63, but was not detected in adult femoral osteoblasts. Osterix expression was also decreased in three human osteosarcoma cell lines. These results suggest that osterix expression may play a role in osteosarcoma tumor growth and metastasis. We hypothesized that osterix might have a role in osteosarcoma tumor growth and metastasis. | Human | EGLN3 | 112399 | egl-9 family hypoxia-inducible factor 3 | In the human osteosarcoma cell line, U2OS, selective suppression of HIF-1alpha expression by RNA interference resulted in a complete loss of hypoxic induction of PHD2 and PHD3. | Human | SARNP | 84324 | SAP domain containing ribonucleoprotein | The in vitro effects of orthosilicic acid (0-50 microM) on collagen type 1 synthesis was investigated using the human osteosarcoma cell line (MG-63), primary osteoblast-like cells derived from human bone marrow stromal cells, and an immortalized human early osteoblastic cell line (HCC1). Osteoblast-like cells derived from pediatric bone explants, adherent stromal cells derived from bone marrow (osteoprogenitors), MG-63 osteosarcoma cells, and SV-40 virally transformed osteoprogenitor cells (HCC1) were studied. | Human | TBC1D3F | 84218 | TBC1 domain family, member 3F | INFERRED, Score=800, UMLKSK CUI: C0029463 | Human | LOXL4 | 84171 | lysyl oxidase-like 4 | Fibroblasts, smooth muscle and osteosarcoma (HOS) cells express LOXL4. | Human | BIRC7 | 79444 | baculoviral IAP repeat containing 7 | High Livin expression is associated with osteosarcoma | Human | RAPH1 | 65059 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | Altered expression and deletion of RMO1 in osteosarcoma. RMO1 is expressed and deleted in osteosarcoma | Human | DAZ4 | 57135 | deleted in azoospermia 4 | INFERRED, Score=800, UMLKSK CUI: C0029463 | Human | ZNF395 | 55893 | zinc finger protein 395 | colocalization of PBF and Scythe/BAT3 in the nucleus might be an important factor for survival of osteosarcoma cells | Human | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | We conclude that somatic hCDC4 mutations are infrequent in osteosarcoma, and are unlikely to play an important role in aneuploidy of this tumor | Human | XAF1 | 54739 | XIAP associated factor 1 | To further study Xaf1 function we generated Xaf1 inducible cells in the osteosarcoma cell line Saos-2. |
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